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公开(公告)号：US5231009A
公开(公告)日：1993-07-27
申请号：US760031
申请日：1991-09-13
IPC分类号： A61K38/00 , C07K14/705 , C07K16/30 , C12N1/21 , C12Q1/68
CPC分类号： C07K14/705 , C07K16/3007 , C12Q1/6886 , A61K38/00 , C07K2319/00 , C07K2319/40 , C12Q2600/158
摘要： A nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.
摘要翻译： 一种核酸，其包含编码CEA家族成员肽序列的碱基序列或具有与其可杂交的碱基序列的核酸，具有包含该核酸的插入片段的可复制重组克隆载体，用该克隆载体转染，感染或注射的细胞，多肽 由这样的细胞表达，衍生自CEA家族成员核酸的编码序列的合成肽，对这些多肽具有特异性的抗体制剂，使用这种抗体制剂检测CEA家族成员的免疫测定法和用于检测CEA家族成员核酸序列的核酸杂交方法，其使用 包含上述核酸的核酸探针。
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公开(公告)号：US6022958A
公开(公告)日：2000-02-08
申请号：US468859
申请日：1995-06-06
IPC分类号： A61K38/00 , C07K14/705 , C07K16/30 , C12N1/21 , C12Q1/68 , C07H21/04 , C12N15/11 , C12N15/79
CPC分类号： C07K14/705 , C07K16/3007 , C12Q1/6886 , A61K38/00 , C07K2319/00 , C07K2319/40
摘要： A nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.
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公开(公告)号：US06342583B1
公开(公告)日：2002-01-29
申请号：US08027974
申请日：1993-03-08
IPC分类号： C07K1400
CPC分类号： C07K14/705 , A61K38/00 , C07K16/3007 , C07K2319/00 , C07K2319/40 , C12Q1/6886 , C12Q2600/158
摘要： A nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.
摘要翻译： 一种核酸，其包含编码CEA家族成员肽序列的碱基序列或具有与其可杂交的碱基序列的核酸，具有包含该核酸的插入片段的可复制重组克隆载体，用该克隆载体转染，感染或注射的细胞，多肽 由这样的细胞表达，衍生自CEA家族成员核酸的编码序列的合成肽，对这些多肽具有特异性的抗体制剂，使用这种抗体制剂检测CEA家族成员的免疫测定法和用于检测CEA家族成员核酸序列的核酸杂交方法，其使用 包含上述核酸的核酸探针。
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4.发明授权Antibody preparations specifically binding to unique determinants of CEA antigens or fragments thereof and use of the antibody preparations in immunoassays 失效特异性结合CEA抗原或其片段的独特决定簇的抗体制剂和在免疫测定中使用抗体制剂
公开(公告)号：US06013772A
公开(公告)日：2000-01-11
申请号：US468856
申请日：1995-06-06
CPC分类号： C07K14/705 , C07K16/3007 , C12Q1/6886 , A61K38/00 , C07K2319/00 , C07K2319/40
摘要： A nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.
摘要翻译： 一种核酸，其包含编码CEA家族成员肽序列的碱基序列或具有与其可杂交的碱基序列的核酸，具有包含该核酸的插入片段的可复制重组克隆载体，用该克隆载体转染，感染或注射的细胞，多肽 由这样的细胞表达，衍生自CEA家族成员核酸的编码序列的合成肽，对这些多肽具有特异性的抗体制剂，使用这种抗体制剂检测CEA家族成员的免疫测定法和用于检测CEA家族成员核酸序列的核酸杂交方法，其使用 包含上述核酸的核酸探针。
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公开(公告)号：US5122599A
公开(公告)日：1992-06-16
申请号：US274107
申请日：1988-11-21
IPC分类号： C12Q1/68 , A61K38/00 , C07K14/435 , C07K14/705 , C07K16/30 , C12N15/12 , C12N15/62 , C07H15/12 , C12N15/00
CPC分类号： C07K14/435 , C07K14/705 , C07K16/3007 , C12N15/62 , C12Q1/6886 , A61K38/00 , C07K2319/00 , C07K2319/40 , C12Q2600/158
摘要： This invention relates to a nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.
摘要翻译： 本发明涉及包含编码CEA家族成员肽序列的碱基序列或具有与其可杂交的碱基序列的核酸的核酸，具有包含该核酸的插入片段的可复制重组克隆载体，转染，感染或注射了这些核酸的细胞 克隆载体，由这些细胞表达的多肽，衍生自CEA家族成员核酸的编码序列的合成肽，对这些多肽具有特异性的抗体制剂，使用这种抗体制剂检测CEA家族成员的免疫测定法和用于检测CEA家族成员的核酸杂交方法 使用包含上述核酸的核酸探针的核酸序列。
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公开(公告)号：US5571710A
公开(公告)日：1996-11-05
申请号：US170134
申请日：1993-12-20
IPC分类号： A61K38/00 , C07K14/705 , C07K16/30 , C12N1/21 , C12N15/12 , C12Q1/68 , C12N5/06 , C07H21/04 , C12N15/00
CPC分类号： C07K14/70503 , C07K14/705 , C07K16/3007 , C12Q1/6886 , A61K38/00 , C07K2319/40 , C07K2319/61
摘要： A nucleic acid encoding a carcinoembryonic antigen (CEA) that cross-reacts with human CEA is described. In addition, vectors and host cells containing such nucleic acids are disclosed.
摘要翻译： 描述了编码与人CEA交叉反应的癌胚抗原（CEA）的核酸。 此外，公开了含有这种核酸的载体和宿主细胞。
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公开(公告)号：US5274087A
公开(公告)日：1993-12-28
申请号：US876821
申请日：1992-04-29
IPC分类号： A61K38/00 , C07K14/705 , C07K16/30 , C12N1/21 , C12N15/12 , C12Q1/68 , C07H15/12 , C07H21/04 , C12N15/00
CPC分类号： C07K14/70503 , C07K14/705 , C07K16/3007 , C12Q1/6886 , A61K38/00 , C07K2319/40 , C07K2319/61
摘要： Nucleic acid sequences are disclosed that encode carcinoembryonic antigens (CEAs) as are replicable recombinant cloning vehicles containing DNA that encodes CEA proteins.
摘要翻译： 公开了编码癌胚抗原（CEA）的核酸序列，其是含有编码CEA蛋白的DNA的可重复克隆载体。
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公开(公告)号：US5843761A
公开(公告)日：1998-12-01
申请号：US469987
申请日：1995-06-06
CPC分类号： C07K14/70503 , C07K14/705 , C07K16/3007 , C12Q1/6886 , A61K38/00 , C07K2319/40 , C07K2319/61
摘要： A nucleic acid comprising a base sequence which codes for a CEA peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or infected with such cloning vehicles, polypeptides expressed by such cells, antibody preparations specific for such polypeptides, immunoassays for detecting CEA using such antibody preparations and nucleic acid hybridization methods for detecting a CEA nucleic acid sequence using a nucleic acid probe comprising the above described nucleic acid.
摘要翻译： 一种核酸，其包含编码CEA肽序列的碱基序列或具有与其可杂交的碱基序列的核酸，具有包含该核酸的插入片段的可复制重组克隆载体，用该克隆载体转染，感染或感染的细胞，由 这样的细胞，对这些多肽有特异性的抗体制剂，使用这种抗体制剂检测CEA的免疫测定法和使用包含上述核酸的核酸探针检测CEA核酸序列的核酸杂交方法。
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公开(公告)号：US5593847A
公开(公告)日：1997-01-14
申请号：US170141
申请日：1993-12-20
IPC分类号： G01N33/574 , C07K16/00 , C12P21/08 , G01N33/53
CPC分类号： G01N33/57415 , Y10S435/81 , Y10S435/975 , Y10S436/813
摘要： A method for aiding in the diagnosis of, and monitoring the progression of, breast cancer in a patient by measuring the amount of NCA 50/90 in a blood sample, e.g. serum sample, obtained from the patient. Measurement in a single sample of an amount of NCA 50/90 significantly higher than the mean amount of NCA 50/90 in the normal population is an indication of breast cancer in the patient. The progression of breast cancer can also be monitored by performing a series of specific immunoassays over time to determine changes in the level of NCA 50/90 in blood samples. Increases in blood NCA 50/90 levels over time are indicative of a deteriorating condition whereas decreasing levels of blood NCA 50/90 over time indicate an improving condition.
摘要翻译： 一种通过测量血液样品中的NCA 50/90的量来辅助诊断和监测患者乳腺癌的进展的方法，例如， 血清样品，从患者获得。 在单个样品中测量NCA 50/90的量显着高于正常人群中NCA 50/90的平均量，这是患者乳腺癌的指征。 乳腺癌的进展也可以通过随时间进行一系列特异性免疫测定来监测血液样品中NCA 50/90水平的变化。 随着时间的推移，血液NCA 50/90水平的升高表明病情恶化，而随着时间的推移，血液NCA 50/90的水平降低表明改善状况。
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公开(公告)号：US20120093840A1
公开(公告)日：2012-04-19
申请号：US13262178
申请日：2010-04-06
申请人： Henrik Østergaard , Anthony Pusateri , Thomas R. Barnett , Jens Buchardt , Bernd Peschke , Mikael Kofod-Hansen , Magali A. Zundel , Carsten Behrens , Eva H. Norling Olsen , Henning Stennicke
发明人： Henrik Østergaard , Anthony Pusateri , Thomas R. Barnett , Jens Buchardt , Bernd Peschke , Mikael Kofod-Hansen , Magali A. Zundel , Carsten Behrens , Eva H. Norling Olsen , Henning Stennicke
CPC分类号： C07K14/755 , A61K38/00 , C07K16/18 , C07K2317/24 , C07K2319/30 , C07K2319/31 , C07K2319/33
摘要： The invention described herein relates to novel molecules and polypeptides comprising at least one amino acid sequence having significant identity with (homology to) human Factor VIII or biologically active portion(s) thereof, related molecules (such as nucleic acids encoding such polypeptides), compositions (such as pharmaceutical formulations) comprising such polypeptides, and methods of making and using such polypeptides.
摘要翻译： 本文所述的本发明涉及新型分子和多肽，其包含至少一个与人因子VIII或其生物活性部分（相同的分子）（例如编码这种多肽的核酸）具有同源性的同一性的氨基酸序列，组合物 （例如药物制剂），以及制备和使用这些多肽的方法。
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