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公开(公告)号：US07846925B2
公开(公告)日：2010-12-07
申请号：US10520621
申请日：2003-07-10
IPC分类号： A61K31/536 , A61K31/53 , A61K31/498 , A61K31/517 , A61K31/4709 , A61K31/427 , A61K31/423 , A61K31/4184 , A61K31/343 , A61K31/352 , C07D265/36 , C07D253/08 , C07D417/02 , C07D241/36 , C07D215/38 , C07D277/32 , C07D261/20 , C07D235/04 , C07D319/16 , C07D317/46 , C07D307/78
CPC分类号： C07D277/20 , A61K31/426 , A61K31/427 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/538 , C07D417/06 , C07D417/14
摘要： The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, graft rejection or lung injuries. Formula (I), wherein A, X, Y, Z, R1, R2 and n are as described in the description.
摘要翻译： 本发明涉及用于治疗和/或预防自身免疫性疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集的式（I）的唑烷二酮 - 乙烯基稠合 - 苯衍生物 ，癌症，移植排斥或肺部损伤。 式（I）其中A，X，Y，Z，R 1，R 2和n如说明书所述。
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公开(公告)号：US20060122176A1
公开(公告)日：2006-06-08
申请号：US10520621
申请日：2003-07-10
IPC分类号： A61K31/538 , A61K31/517 , A61K31/498 , A61K31/4709 , A61K31/427 , A61K31/426 , C07D417/02
CPC分类号： C07D277/20 , A61K31/426 , A61K31/427 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/538 , C07D417/06 , C07D417/14
摘要： The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, graft rejection or lung injuries. Formula (I), wherein A, X, Y, Z, R1, R2 and n are as described in the description.
摘要翻译： 本发明涉及用于治疗和/或预防自身免疫性疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集的式（I）的唑烷二酮 - 乙烯基稠合 - 苯衍生物 ，癌症，移植排斥或肺部损伤。 式（I）其中A，X，Y，Z，R 1，R 2和n如说明书所述。
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公开(公告)号：US20110312960A1
公开(公告)日：2011-12-22
申请号：US13222072
申请日：2011-08-31
申请人： Pascale Gaillard , Anna Quattropani , Vincent Pomel , Thomas Rueckle , Jasna Klicic , Dennis Church
发明人： Pascale Gaillard , Anna Quattropani , Vincent Pomel , Thomas Rueckle , Jasna Klicic , Dennis Church
IPC分类号： A61K31/498 , C07D413/14 , C07D471/04 , A61K31/5377 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/28 , A61P31/04 , A61P31/12 , A61P37/08 , A61P11/06 , A61P1/18 , A61P13/12 , A61P7/02 , A61P35/00 , A61P37/06 , A61P15/08 , A61P7/00 , A61P11/00 , A61P17/06 , A61P19/04 , A61P1/00 , A61P25/00 , A61P25/14 , A61P9/10 , A61P9/08 , A61P21/00 , A61P35/04 , C07D241/44
CPC分类号： C07D241/44 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
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公开(公告)号：US08071597B2
公开(公告)日：2011-12-06
申请号：US12064284
申请日：2006-08-25
申请人： Pascale Gaillard , Anna Quattropani , Vincent Pomel , Thomas Rueckle , Jasna Klicic , Dennis Church
发明人： Pascale Gaillard , Anna Quattropani , Vincent Pomel , Thomas Rueckle , Jasna Klicic , Dennis Church
IPC分类号： A61K31/50 , A61K31/495 , A01N43/58 , A01N43/60 , C07D241/36
CPC分类号： C07D241/44 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的吡嗪衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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公开(公告)号：US08877757B2
公开(公告)日：2014-11-04
申请号：US13222072
申请日：2011-08-31
申请人： Pascale Gaillard , Anna Quattropani , Vincent Pomel , Thomas Rueckle , Jasna Klicic , Dennis Church
发明人： Pascale Gaillard , Anna Quattropani , Vincent Pomel , Thomas Rueckle , Jasna Klicic , Dennis Church
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D471/00 , C07D403/12 , C07D405/12 , C07D241/44 , C07D471/04 , C07D407/12 , C07D409/12 , C07D401/12 , C07D417/12 , C07D413/12
CPC分类号： C07D241/44 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的吡嗪衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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公开(公告)号：US20090082356A1
公开(公告)日：2009-03-26
申请号：US12064284
申请日：2006-08-25
申请人： Pascale Gaillard , Anna Quattropani , Vincent Pomel , Thomas Rueckle , Jasna Klicic , Dennis Church
发明人： Pascale Gaillard , Anna Quattropani , Vincent Pomel , Thomas Rueckle , Jasna Klicic , Dennis Church
IPC分类号： A61K31/498 , C07D239/72 , A61P25/28 , A61P29/00 , A61P1/00
CPC分类号： C07D241/44 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的吡嗪衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症， 移植，移植排斥或肺部损伤。
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公开(公告)号：US07259162B2
公开(公告)日：2007-08-21
申请号：US10168718
申请日：2000-12-20
IPC分类号： C07D417/06 , A61K31/506
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/64 , C07D417/06 , C07D417/14
摘要： The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said benzazole derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and/or 3. The present invention is furthermore related to novel benzazole derivatives as well as to methods of their preparation. X is O, S or NR0, with R0 being H or an unsubstituted or substituted C1-C6 alkyl;G is an unsubstituted or substituted pyrimidinyl group.
摘要翻译： 本发明涉及特别用作药物活性化合物的苯并唑衍生物以及含有这种苯并唑衍生物的药物制剂。 所述的苯并唑衍生物是JNK途径的有效调节剂，它们特别是JNK2和/或3的有效和选择性抑制剂。本发明还涉及新的苯并唑衍生物及其制备方法。 X是O，S或NR 0，其中R 0是H或未取代或取代的C 1 -C 6 - 烷基; G是未取代或取代的嘧啶基。
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公开(公告)号：US07470686B2
公开(公告)日：2008-12-30
申请号：US11779585
申请日：2007-07-18
IPC分类号： A61K31/506 , C07D417/06
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/64 , C07D417/06 , C07D417/14
摘要： The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said benzazole derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and/or 3. The present invention is furthermore related to novel benzazole derivatives as well as to methods of their preparation. X is O, S or NR0, with R0 being H or an unsubstantiated or substituted C1-C6 alkyl; G is an unsubstantiated or substituted pyrimidinyl group.
摘要翻译： 本发明涉及特别用作药物活性化合物的苯并唑衍生物以及含有这种苯并唑衍生物的药物制剂。 所述的苯并唑衍生物是JNK途径的有效调节剂，它们特别是JNK2和/或3的有效和选择性抑制剂。本发明还涉及新的苯并唑衍生物及其制备方法。 X为O，S或NRO，其中R 0为H或未经取代或取代的C 1 -C 6烷基; G是未经证实或取代的嘧啶基。
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公开(公告)号：US20070259892A1
公开(公告)日：2007-11-08
申请号：US11779585
申请日：2007-07-18
IPC分类号： A61K31/506 , A61K31/426 , C07D277/62 , C07D401/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/64 , C07D417/06 , C07D417/14
摘要： The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said benzazole derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and/or 3. The present invention is furthermore related to novel benzazole derivatives as well as to methods of their preparation. X is O, S or NR0, with R0 being H or an unsubstituted or substituted C1-C6 alkyl; G is an unsubstituted or substituted pyrimidinyl group.
摘要翻译： 本发明涉及特别用作药物活性化合物的苯并唑衍生物以及含有这种苯并唑衍生物的药物制剂。 所述的苯并唑衍生物是JNK途径的有效调节剂，它们特别是JNK2和/或3的有效和选择性抑制剂。本发明还涉及新的苯并唑衍生物及其制备方法。 X是O，S或NR 0，其中R 0是H或未取代或取代的C 1 -C 6 - 烷基; G是未取代或取代的嘧啶基。
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公开(公告)号：US07776854B2
公开(公告)日：2010-08-17
申请号：US10496785
申请日：2002-12-06
IPC分类号： A61K31/535
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/506
摘要： The present invention is related to the use of benzazole derivatives of formula (I) for the treatment and/or prevention of scleroderma and its therapeutic implications selected in the group consisting of systemic sclerosis, scleroderma-like disorders, sine scleroderma, liver cirrhosis, interstitial pulmonary fibrosis, Dupuytren's contracture, keloid and other scarring/wound healing abnormalities, postoperative adhesions and reactive fibrosis, as well as chronic heart failure, in particular after myocardial infarction.
摘要翻译： 本发明涉及式（I）的苯并唑衍生物在治疗和/或预防硬皮病中的应用及其治疗意义，其选自系统性硬化症，硬皮病样疾病，正辛硬脂酸，肝硬化，间质性 肺纤维化，Dupuytren挛缩，瘢痕疙瘩和其他瘢痕/伤口愈合异常，术后粘连和反应性纤维化，以及慢性心力衰竭，特别是心肌梗死后。
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