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    Mutant glycoproteins
    7.
    发明授权
    Mutant glycoproteins 有权
    突变型糖蛋白

    公开(公告)号：US07317095B2

    公开(公告)日：2008-01-08

    申请号：US10493540

    申请日：2002-10-22

    申请人： William H. Brondyk ,  Xuliang Jiang ,  Robert Campbell

    发明人： William H. Brondyk ,  Xuliang Jiang ,  Robert Campbell

    IPC分类号： C07K14/59 ,  C12N15/00 ,  C12N15/63 ,  C12N5/00

    CPC分类号： C07K14/59 ,  A61K38/00

    摘要： The inventors have designed novel FSH mutants with increased glycosylation and longer half-lives for use in inducing folliculogenesis in human patients. The use of a FSH mutant preparation of the invention permits the use of lower cumulative doses of FSH to achieve the same or better clinical result.

    摘要翻译： 本发明人设计了具有增加的糖基化和更长半衰期的新型FSH突变体用于诱导人类患者的卵泡发生。 使用本发明的FSH突变体制剂允许使用较低累积剂量的FSH来实现相同或更好的临床结果。

    METHODS OF INCERASING PROTEIN EXPESSION LEVELS
    8.
    发明申请
    METHODS OF INCERASING PROTEIN EXPESSION LEVELS 失效
    蛋白质渗透水平的方法

    公开(公告)号：US20050074840A1

    公开(公告)日：2005-04-07

    申请号：US10496218

    申请日：2004-09-13

    申请人： William Brondyk ,  Xuliang Jiang ,  Rene Schweickhardt

    发明人： William Brondyk ,  Xuliang Jiang ,  Rene Schweickhardt

    IPC分类号： C12N15/09 ,  C07K14/47 ,  C07K14/715 ,  C12N15/00 ,  C12P21/02 ,  C07H21/04

    CPC分类号： C12P21/02 ,  C07K14/7151 ,  C12N15/00 ,  Y10S930/144

    摘要： Abstract of the DisclosureThe present invention relates to methods of increasing protein expression levels whereby at least one amino acid in a protein amino acid sequence is substituted for the amino acid, proline. Preferably, the substitution occurs within 15 amino acids, more preferably within 10 amino acids and most preferably within 5 amino acids of a cysteine amino acid residue. The present invention not only includes methods for polypeptides with proline substitutions, but also polynucleotides with codon substitutions for which a codon for any amino acid, except proline, is substituted for a codon encoding for proline.

    摘要翻译： 发明内容本发明涉及增加蛋白质表达水平的方法，其中蛋白质氨基酸序列中的至少一个氨基酸被氨基酸脯氨酸取代。 优选地，取代发生在半胱氨酸氨基酸残基的15个氨基酸内，更优选在10个氨基酸内，最优选在5个氨基酸内。 本发明不仅包括具有脯氨酸取代的多肽的方法，而且还包括具有密码子取代的多核苷酸，除了脯氨酸之外，任何氨基酸的密码子都代替编码脯氨酸的密码子。

    Method for producing of ultra-clean and high-purity aqueous hydrogen peroxide solution
    10.
    发明授权
    Method for producing of ultra-clean and high-purity aqueous hydrogen peroxide solution 有权
    超清洁和高纯度过氧化氢水溶液的生产方法

    公开(公告)号：US08715613B2

    公开(公告)日：2014-05-06

    申请号：US12981541

    申请日：2010-12-30

    申请人： Jiarong Zhan ,  Zhen Song ,  Xuliang Jiang

    发明人： Jiarong Zhan ,  Zhen Song ,  Xuliang Jiang

    IPC分类号： C01B15/01

    CPC分类号： B01J20/28083 ,  B01D61/025 ,  B01D61/04 ,  B01D2311/04 ,  B01D2311/2626 ,  B01J20/103 ,  B01J20/3204 ,  B01J20/3246 ,  B01J20/3248 ,  C01B15/0135

    摘要： The present invention relates to a method for producing of ultra-clean and high-purity aqueous hydrogen peroxide solution. Industrial grade hydrogen peroxide is filtered by SBA-15 molecular sieve with which the chelator is loaded, and then it is further filtered by a hyperfiltration membrane to obtain the ultra-clean and high-purity aqueous hydrogen peroxide solution. The method provided in the present invention overcomes the problems such as complexity of operation, high energy consumption and high content of impurities in the product, and is suitable for continuous production on a large scale because of its simple equipment, simple operation, low energy consumption and stable quality of the product.

    摘要翻译： 本发明涉及一种生产超清洁和高纯度过氧化氢水溶液的方法。 工业级过氧化氢用负载螯合剂的SBA-15分子筛过滤，然后用超滤膜进一步过滤，得到超清洁和高纯度的过氧化氢水溶液。 本发明提供的方法克服了操作复杂性高，能耗高，产品杂质含量高等问题，其设备简单，操作简便，能耗低，适合大规模连续生产 稳定的产品质量。