公开(公告)号：US20050106648A1

公开(公告)日：2005-05-19

申请号：US11020509

申请日：2004-12-27

申请人： Timothy Foster ,  Fiona Roche ,  Mark Pallen ,  Joseph Patti ,  Jeff Hutchins ,  Pietro Speziale

发明人： Timothy Foster ,  Fiona Roche ,  Mark Pallen ,  Joseph Patti ,  Jeff Hutchins ,  Pietro Speziale

IPC分类号： G01N33/53 ,  A61K39/00 ,  A61K39/395 ,  A61K39/40 ,  A61P31/04 ,  C07K14/31 ,  C07K16/12 ,  C12P21/08 ,  G01N33/569 ,  G01N33/554

CPC分类号： C07K16/1271

摘要： Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S. hemolyticus, are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.

摘要翻译： 提供了对凝固酶阳性葡萄球菌细菌如金黄色葡萄球菌和凝血酶阴性细菌如表皮葡萄球菌和溶血性溶血性葡萄球菌交叉反应的多克隆和单克隆抗体，其可以识别来自凝固酶 - 阳性和凝固酶阴性葡萄球菌。 抗体可以从基于在金黄色葡萄球菌和凝固酶阴性葡萄球菌之间常见的特征分离的表面蛋白产生，并且这些重组表面蛋白质用于产生本发明的抗体。 还提供了利用这些蛋白质和抗体用于治疗或保护各种葡萄球菌感染的疫苗和方法。

公开(公告)号：US06841154B2

公开(公告)日：2005-01-11

申请号：US10172502

申请日：2002-06-17

申请人： Timothy Foster ,  Fiona Roche ,  Mark Pallen ,  Joseph M. Patti ,  Jeff T. Hutchins ,  Pietro Speziale

发明人： Timothy Foster ,  Fiona Roche ,  Mark Pallen ,  Joseph M. Patti ,  Jeff T. Hutchins ,  Pietro Speziale

IPC分类号： G01N33/53 ,  A61K39/00 ,  A61K39/395 ,  A61K39/40 ,  A61P31/04 ,  C07K14/31 ,  C07K16/12 ,  C12P21/08 ,  G01N33/569

CPC分类号： C07K16/1271

摘要： Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S. hemolyticus, are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.

摘要翻译： 提供了对凝固酶阳性葡萄球菌细菌如金黄色葡萄球菌和凝血酶阴性细菌如表皮葡萄球菌和溶血性溶血性葡萄球菌交叉反应的多克隆和单克隆抗体，其可以识别来自凝固酶 - 阳性和凝固酶阴性葡萄球菌。 抗体可以从基于在金黄色葡萄球菌和凝固酶阴性葡萄球菌之间常见的特征分离的表面蛋白产生，并且这些重组表面蛋白质用于产生本发明的抗体。 还提供了利用这些蛋白质和抗体用于治疗或保护各种葡萄球菌感染的疫苗和方法。

公开(公告)号：US20090202578A1

公开(公告)日：2009-08-13

申请号：US12365481

申请日：2009-02-04

申请人： Timothy FOSTER ,  Fiona Roche ,  Mark Pallen ,  Joseph M. Patti ,  Jeff T. Hutchins ,  Pietro Speziale

发明人： Timothy FOSTER ,  Fiona Roche ,  Mark Pallen ,  Joseph M. Patti ,  Jeff T. Hutchins ,  Pietro Speziale

IPC分类号： A61K39/085 ,  A61K38/16 ,  G01N33/569

CPC分类号： C07K16/1271

摘要： Surface proteins are provided which generate polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S. hemolyticus. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, or the A domains of those surface proteins, and these recombinant surface proteins are used to generate the cross-reactive antibodies. Vaccines comprising an immunologically effective amount of the proteins are also provided, and these vaccines are used in methods for the treatment or protection against a wide variety of staphylococcal infections.

摘要翻译： 提供了表达蛋白，其产生与凝固酶阳性葡萄球菌如金黄色葡萄球菌和凝血酶阴性细菌如表皮葡萄球菌和溶血性葡萄球菌的交叉反应性的多克隆和单克隆抗体。 抗体可以从基于在金黄色葡萄球菌和凝固酶阴性葡萄球菌或这些表面蛋白质的A结构域可能是常见的特征分离的表面蛋白产生，并且这些重组表面蛋白质用于产生 交叉反应性抗体。 还提供了包含免疫有效量的蛋白质的疫苗，并且这些疫苗用于治疗或保护免受各种葡萄球菌感染的方法中。

公开(公告)号：US07968100B2

公开(公告)日：2011-06-28

申请号：US12365481

申请日：2009-02-04

申请人： Timothy Foster ,  Fiona Roche ,  Mark Pallen ,  Joseph M. Patti ,  Jeff T. Hutchins ,  Pietro Speziale

发明人： Timothy Foster ,  Fiona Roche ,  Mark Pallen ,  Joseph M. Patti ,  Jeff T. Hutchins ,  Pietro Speziale

IPC分类号： A61K39/085 ,  A61K38/16 ,  G01N33/569

CPC分类号： C07K16/1271

摘要： Surface proteins are provided which generate polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S. hemolyticus. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, or the A domains of those surface proteins, and these recombinant surface proteins are used to generate the cross-reactive antibodies. Vaccines comprising an immunologically effective amount of the proteins are also provided, and these vaccines are used in methods for the treatment or protection against a wide variety of staphylococcal infections.

摘要翻译： 提供了表达蛋白，其产生与凝固酶阳性葡萄球菌如金黄色葡萄球菌和凝血酶阴性细菌如表皮葡萄球菌和溶血性葡萄球菌的交叉反应性的多克隆和单克隆抗体。 抗体可以从基于在金黄色葡萄球菌和凝固酶阴性葡萄球菌或这些表面蛋白质的A结构域可能是常见的特征分离的表面蛋白产生，并且这些重组表面蛋白质用于产生 交叉反应性抗体。 还提供了包含免疫有效量的蛋白质的疫苗，并且这些疫苗用于治疗或保护免受各种葡萄球菌感染的方法中。