公开(公告)号：US20050089881A1

公开(公告)日：2005-04-28

申请号：US10780149

申请日：2004-02-17

申请人： Jeff Hutchins ,  Klaus Kuettner ,  Kathryn Lindley ,  Thomas Schmid ,  Barbara Schumacher ,  Stephen Stimpson ,  Jui-Lan Su

发明人： Jeff Hutchins ,  Klaus Kuettner ,  Kathryn Lindley ,  Thomas Schmid ,  Barbara Schumacher ,  Stephen Stimpson ,  Jui-Lan Su

IPC分类号： C07K16/18 ,  C12N5/20 ,  G01N33/68 ,  C12Q1/68

CPC分类号： C07K16/18 ,  A61K2039/53 ,  C12N2799/026 ,  G01N33/6887 ,  G01N2500/00 ,  G01N2800/105 ,  G01N2800/52

摘要： The invention provides an antibody or a fragment thereof having specific binding affinity for superficial zone protein (SZP) or a variant, fragment, or protein core thereof, wherein the binding affinity of the antibody or fragment thereof for human superficial zone protein is the same or greater than the binding affinity for bovine superficial zone protein in a competitive binding assay, IAsys analysis, or BIAcore analysis. The present invention further provides hybidoma cells that produce the monoclonal antibody and antibody reagent kits comprising the antibody or fragment of the invention. Further provided by the invention are methods of SZP detection, methods of diagnosing a degenerative joint condition, and screening methods related to the use of the antibody or fragment thereof.

摘要翻译： 本发明提供对表浅区蛋白（SZP）或其变体，片段或蛋白核心具有特异性结合亲和力的抗体或其片段，其中抗体或其片段对人表皮区蛋白的结合亲和力相同或 在竞争性结合测定，IAsys分析或BIAcore分析中大于牛表面区蛋白的结合亲和力。 本发明还提供产生单克隆抗体的杂交瘤细胞和包含本发明的抗体或片段的抗体试剂盒。 本发明还提供了SZP检测方法，诊断退行性关节病的方法以及与抗体或其片段的使用相关的筛选方法。

公开(公告)号：US08759318B2

公开(公告)日：2014-06-24

申请号：US13143098

申请日：2010-01-11

申请人： Stanley Chamberlain ,  Jeff Hutchins ,  Karolina Madela ,  Christopher McGuigan ,  John Vernachio ,  Mohamed Aljarah ,  Arnaud Gilles

发明人： Stanley Chamberlain ,  Jeff Hutchins ,  Karolina Madela ,  Christopher McGuigan ,  John Vernachio ,  Mohamed Aljarah ,  Arnaud Gilles

IPC分类号： A01N43/04 ,  A61K31/70

CPC分类号： C07H19/207 ,  C07H19/167

摘要： Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.

摘要翻译： 提供了衍生自具有增强的治疗效力的鸟嘌呤碱基的氨基磷酸酯化合物，并且这些化合物在治疗病毒感染方面尤其具有增强的效力，例如丙型肝炎病毒。 还提供了药物组合物，制备化合物的方法，以及使用该化合物和组合物治疗病毒感染的方法。

公开(公告)号：US20050287164A1

公开(公告)日：2005-12-29

申请号：US11136559

申请日：2005-05-25

申请人： Joseph Patti ,  Jeff Hutchins ,  Paul Domanski ,  Pratiksha Patel ,  Andrea Hall

发明人： Joseph Patti ,  Jeff Hutchins ,  Paul Domanski ,  Pratiksha Patel ,  Andrea Hall

IPC分类号： G01N33/53 ,  A61K9/12 ,  A61K9/72 ,  A61K39/395 ,  A61P31/04 ,  C07K14/31 ,  C07K16/12 ,  C07K19/00 ,  C12N15/09 ,  C12P21/08 ,  G01N33/532 ,  G01N33/577 ,  G01N33/554 ,  A61K39/02 ,  G01N33/569

CPC分类号： C07K16/1271 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2319/00

摘要： Monoclonal antibodies which can bind to the ClfA protein and which are generated from binding subdomains or active fragments of the ClfA protein from Staphylococcus aureus, including the active fragments proteins from its fibrinogen binding domain such as Clf40 protein, the Clf33 protein, or ClfA N3, are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus aureus. In addition, medical instruments can be treated using the monoclonal antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the antibodies of the present invention are advantageous because they can prevent adherence of the bacteria to host cells by impairing or inhibiting the ability of S. aureus ClfA to bind to fibrinogen or fibrin, and thus can be utilized in methods or treating or preventing staphylococcal inventions.

公开(公告)号：US20120052046A1

公开(公告)日：2012-03-01

申请号：US13143098

申请日：2010-01-11

申请人： Stanley Chamberlain ,  Jeff Hutchins ,  Karolina Madela ,  Christopher McGuigam ,  John Vernachio ,  Mohamed Aljarah ,  Arnaud Gilles

发明人： Stanley Chamberlain ,  Jeff Hutchins ,  Karolina Madela ,  Christopher McGuigam ,  John Vernachio ,  Mohamed Aljarah ,  Arnaud Gilles

IPC分类号： A61K38/21 ,  A61K31/7076 ,  C07H19/167 ,  A61P31/14 ,  A61K38/16 ,  A61K31/7105 ,  C07H1/06 ,  C07H19/20 ,  C07H19/16

CPC分类号： C07H19/207 ,  C07H19/167

摘要： Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.

摘要翻译： 提供了衍生自具有增强的治疗效力的鸟嘌呤碱基的氨基磷酸酯化合物，并且这些化合物在治疗病毒感染方面尤其具有增强的效力，例如丙型肝炎病毒。 还提供了药物组合物，制备化合物的方法，以及使用该化合物和组合物治疗病毒感染的方法。

公开(公告)号：US06649366B2

公开(公告)日：2003-11-18

申请号：US09745989

申请日：2000-12-21

申请人： Susan Chubinskaya ,  Jeff Hutchins ,  Juergen Mollenhauer ,  Francis X. Tavares ,  Stephen A. Thomson ,  Jennings F. Worley

发明人： Susan Chubinskaya ,  Jeff Hutchins ,  Juergen Mollenhauer ,  Francis X. Tavares ,  Stephen A. Thomson ,  Jennings F. Worley

IPC分类号： C12Q102

CPC分类号： G01N33/5044 ,  A61K31/00 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K49/0004 ,  G01N33/5008 ,  G01N33/5017 ,  G01N33/502 ,  G01N33/5088 ,  G01N33/6887 ,  G01N2500/00 ,  G01N2510/00 ,  G01N2800/102 ,  G01N2800/105

摘要： The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the subject a therapeutically effective amount of an agent that attenuates annexin function. Also provided are various methods of screening for agents and genes that increase collagen synthesis, decrease collagen degradation, or reduce or delay apoptosis, and methods of using the identified agents or nucleic acids for attaining or maintaining cartilage homeostasis, promoting cartilage repair, increasing collagen synthesis, decreasing collagen degradation, or reducing or delaying apoptosis. The invention also provides methods of decreasing mineralization of vesicles derived from chondrocytes and of promoting endochondral bone growth using agents that attenuates annexin function. The present invention also provides a composition comprising isolated chondrocytes, an agent that attenuates annexin function, and collagen fragments or other means for challenging chondrocytes, including for example, collagen fragments, collagen peptides, or immune mediators.

公开(公告)号：US20050106648A1

公开(公告)日：2005-05-19

申请号：US11020509

申请日：2004-12-27

申请人： Timothy Foster ,  Fiona Roche ,  Mark Pallen ,  Joseph Patti ,  Jeff Hutchins ,  Pietro Speziale

发明人： Timothy Foster ,  Fiona Roche ,  Mark Pallen ,  Joseph Patti ,  Jeff Hutchins ,  Pietro Speziale

IPC分类号： G01N33/53 ,  A61K39/00 ,  A61K39/395 ,  A61K39/40 ,  A61P31/04 ,  C07K14/31 ,  C07K16/12 ,  C12P21/08 ,  G01N33/569 ,  G01N33/554

CPC分类号： C07K16/1271

摘要： Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S. hemolyticus, are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.

摘要翻译： 提供了对凝固酶阳性葡萄球菌细菌如金黄色葡萄球菌和凝血酶阴性细菌如表皮葡萄球菌和溶血性溶血性葡萄球菌交叉反应的多克隆和单克隆抗体，其可以识别来自凝固酶 - 阳性和凝固酶阴性葡萄球菌。 抗体可以从基于在金黄色葡萄球菌和凝固酶阴性葡萄球菌之间常见的特征分离的表面蛋白产生，并且这些重组表面蛋白质用于产生本发明的抗体。 还提供了利用这些蛋白质和抗体用于治疗或保护各种葡萄球菌感染的疫苗和方法。