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公开(公告)号：US07829021B2
公开(公告)日：2010-11-09
申请号：US11839531
申请日：2007-08-15
申请人： Timothy Hutchins , Hal Watts , Steven Scampini , Eric Grimes , Andrew H. Fischer
发明人： Timothy Hutchins , Hal Watts , Steven Scampini , Eric Grimes , Andrew H. Fischer
IPC分类号： G01N21/00
CPC分类号： C12M47/00 , G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.
摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。
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公开(公告)号：US07914462B2
公开(公告)日：2011-03-29
申请号：US11839528
申请日：2007-08-15
申请人： Timothy Hutchins , Hal Watts , Steven Scampini , Eric Grimes , Andrew H. Fischer
发明人： Timothy Hutchins , Hal Watts , Steven Scampini , Eric Grimes , Andrew H. Fischer
CPC分类号： C12M47/00 , G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.
摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。
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公开(公告)号：US20080081363A1
公开(公告)日：2008-04-03
申请号：US11839531
申请日：2007-08-15
申请人： Timothy Hutchins , Hal Watts , Steven Scampini , Eric Grimes , Andrew Fischer
发明人： Timothy Hutchins , Hal Watts , Steven Scampini , Eric Grimes , Andrew Fischer
IPC分类号： C12M3/04
CPC分类号： C12M47/00 , G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.
摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。
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公开(公告)号：US20080081351A1
公开(公告)日：2008-04-03
申请号：US11839528
申请日：2007-08-15
申请人： Timothy Hutchins , Hal Watts , Steven Scampini , Eric Grimes , Andrew Fischer
发明人： Timothy Hutchins , Hal Watts , Steven Scampini , Eric Grimes , Andrew Fischer
IPC分类号： C12Q1/24
CPC分类号： C12M47/00 , G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.
摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。
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公开(公告)号：US20080057573A1
公开(公告)日：2008-03-06
申请号：US11839533
申请日：2007-08-15
申请人： Timothy Hutchins , Hal Watts , Steven Scampini , Eric Grimes
发明人： Timothy Hutchins , Hal Watts , Steven Scampini , Eric Grimes
IPC分类号： C12M1/00
CPC分类号： C12M47/00 , G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.
摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。
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公开(公告)号：US08088329B2
公开(公告)日：2012-01-03
申请号：US12876879
申请日：2010-09-07
IPC分类号： G01N21/00
CPC分类号： C12M47/00 , G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.
摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。
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公开(公告)号：US07914738B2
公开(公告)日：2011-03-29
申请号：US11839533
申请日：2007-08-15
申请人： Timothy Hutchins , Hal Watts , Steven A. Scampini , Eric Grimes
发明人： Timothy Hutchins , Hal Watts , Steven A. Scampini , Eric Grimes
IPC分类号： G01N21/00
CPC分类号： C12M47/00 , G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.
摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。
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公开(公告)号：US20100330660A1
公开(公告)日：2010-12-30
申请号：US12876879
申请日：2010-09-07
IPC分类号： C12M1/36
CPC分类号： C12M47/00 , G01N1/36 , Y10T436/25 , Y10T436/2575
摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.
摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。
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