公开(公告)号：US07829021B2

公开(公告)日：2010-11-09

申请号：US11839531

申请日：2007-08-15

申请人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew H. Fischer

发明人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew H. Fischer

IPC分类号： G01N21/00

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.

摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

公开(公告)号：US07914462B2

公开(公告)日：2011-03-29

申请号：US11839528

申请日：2007-08-15

申请人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew H. Fischer

发明人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew H. Fischer

IPC分类号： A61B10/10 ,  B01L3/02 ,  C12M1/00 ,  G01N1/30

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.

摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

公开(公告)号：US20080081363A1

公开(公告)日：2008-04-03

申请号：US11839531

申请日：2007-08-15

申请人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew Fischer

发明人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew Fischer

IPC分类号： C12M3/04

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.

摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

公开(公告)号：US20080081351A1

公开(公告)日：2008-04-03

申请号：US11839528

申请日：2007-08-15

申请人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew Fischer

发明人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew Fischer

IPC分类号： C12Q1/24

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.

摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

公开(公告)号：US20080057573A1

公开(公告)日：2008-03-06

申请号：US11839533

申请日：2007-08-15

申请人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes

发明人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes

IPC分类号： C12M1/00

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.

摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

公开(公告)号：US20070140915A1

公开(公告)日：2007-06-21

申请号：US11530300

申请日：2006-09-08

申请人： Robert Sakal ,  Hal Watts ,  Steven Scampini

发明人： Robert Sakal ,  Hal Watts ,  Steven Scampini

IPC分类号： B01L3/02

CPC分类号： B01L3/0272 ,  B01L3/50825 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2300/0832 ,  B01L2400/0633 ,  G01N35/0099 ,  G01N2035/00524

摘要： An instrument for automated processing of sample vials are provided. The instrument causes an aliquot chamber within the vial to be filled with the fluid contained within the vial.

摘要翻译： 提供了一种用于样品瓶自动处理的仪器。 该仪器使小瓶内的等分试样室充满容纳在小瓶内的流体。

公开(公告)号：US08137642B2

公开(公告)日：2012-03-20

申请号：US12482731

申请日：2009-06-11

申请人： Timothy Hutchins ,  Steven Scampini ,  Eric Baur

发明人： Timothy Hutchins ,  Steven Scampini ,  Eric Baur

IPC分类号： G01D18/00

CPC分类号： G01N1/36

摘要： A bubble point of a combination of a filter and a liquid is calibrated by applying an initial back pressure through the filter toward the liquid; taking a first plurality of measurements of the level of the liquid in the container; calculating a first variance of the first plurality of measurements; and comparing the first calculated variance with a known threshold variance. Then a second plurality of measurements of the level of the liquid in the container is taken; a second variance of the second plurality of measurements is calculated; and the second calculated variance is compared with a known threshold variance. The above described steps are repeated at incrementally increased back pressures until the first and second calculated variances are each greater than or equal to the known threshold variance, which is about 0.01. The bubble point is determined to be the back pressure at that point. If the determined bubble point is less than or equal to the known threshold bubble point, which is about 0.8 pounds per square inch, the filter is identified as unsuitable for use in cell block formation.

摘要翻译： 过滤器和液体的组合的起泡点通过将初始的背压通过过滤器朝向液体进行校准; 对容器中液体的水平进行第一次多次测量; 计算所述第一多个测量的第一方差; 以及将第一计算的方差与已知的阈值方差进行比较。 然后取出容器中的液体水平的第二多个测量值; 计算第二多个测量的第二方差; 并将第二计算方差与已知的阈值方差进行比较。 上述步骤以逐渐增加的背压重复，直到第一和第二计算的方差各自大于或等于已知阈值方差，其为约0.01。 泡点确定为此时的背压。 如果确定的气泡点小于或等于已知的阈值气泡点（约0.8磅/平方英寸），则过滤器被识别为不适合用于细胞块形成。

公开(公告)号：US07270634B2

公开(公告)日：2007-09-18

申请号：US10780443

申请日：2004-02-17

申请人： Steven Scampini ,  Michael Peszynski ,  Ivan Salgo ,  Bernard Savord

发明人： Steven Scampini ,  Michael Peszynski ,  Ivan Salgo ,  Bernard Savord

IPC分类号： A61B8/00

CPC分类号： G01S7/52074 ,  A61B5/061 ,  A61B5/062 ,  A61B5/063 ,  A61B5/065 ,  A61B5/068 ,  A61B8/00 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/483 ,  G01S7/52073 ,  G01S7/52085 ,  G01S7/52095 ,  G01S15/8993 ,  Y10S128/916

摘要： A three dimensional ultrasonic diagnostic imaging system is operated to guide or observe the operation of an invasive medical device (30) in three dimensions. The appearance of the invasive device (30) in the three dimensional ultrasonic image is enhanced to be more readily observable by a clinician. The enhancement is produced by transmitting a greater ultrasonic beam density in a subvolumetric region including the invasive device (30) than in the surrounding portion of the volumetric region (120). The beam density may be uniformly high in the subvolumetric region and uniformly low in the surrounding region, or may taper from a relatively high beam density around the invasive device (30) to a minimum beam density at distances removed from the invasive device (30).

摘要翻译： 操作三维超声诊断成像系统以引导或观察三维的侵入性医疗装置（30）的操作。 三维超声图像中的侵入性装置（30）的外观被增强以便由临床医生更容易观察到。 通过在包括侵入性装置（30）的子体积区域中比在体积区域（120）的周围部分中传输更大的超声波束密度来产生增强。 光束密度可以在子体积区域中均匀地高，并且在周围区域中均匀地低，或者可以从入侵设备（30）周围的相对较高的光束密度逐渐减小到从侵入性设备（30）移除的距离处的最小光束密度， 。

公开(公告)号：US20070173737A1

公开(公告)日：2007-07-26

申请号：US11725846

申请日：2007-03-20

申请人： Steven Scampini

发明人： Steven Scampini

IPC分类号： A61B10/00

CPC分类号： A61B10/0045 ,  A61B10/0291 ,  A61B2010/0074

摘要： This invention relates generally to medical devices, and more particularly, an apparatus and method for collecting cells or tissue samples from the cervix of a patient for medical testing.

摘要翻译： 本发明一般涉及医疗装置，更具体地说，涉及用于从用于医学测试的患者子宫颈收集细胞或组织样本的装置和方法。

公开(公告)号：US20070142746A1

公开(公告)日：2007-06-21

申请号：US11314754

申请日：2005-12-21

申请人： Steven Scampini

发明人： Steven Scampini

IPC分类号： A61B10/00

CPC分类号： A61B10/0045 ,  A61B10/0291 ,  A61B2010/0074

摘要： This invention relates generally to medical devices, and more particularly, an apparatus and method for collecting cells or tissue samples from the cervix of a patient for medical testing.