公开(公告)号：US20060141623A1

公开(公告)日：2006-06-29

申请号：US10510777

申请日：2003-04-08

申请人： Timothy Smith ,  M Sydney ,  Hagg Rupert ,  Tommasini Roberto ,  Larcher Yves ,  D Kowell

发明人： Timothy Smith ,  M Sydney ,  Hagg Rupert ,  Tommasini Roberto ,  Larcher Yves ,  D Kowell

IPC分类号： C12N5/08

CPC分类号： C12M21/08 ,  C12M23/28 ,  C12M23/42 ,  C12M23/52 ,  C12M25/14 ,  C12M29/04 ,  C12M41/46 ,  C12M41/48 ,  C12M45/09 ,  C12M47/06 ,  C12M47/12 ,  C12N5/0068 ,  C12N5/0618 ,  C12N5/0654 ,  C12N5/0655 ,  C12N2509/00

摘要： The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.