公开(公告)号：US20060141623A1

公开(公告)日：2006-06-29

申请号：US10510777

申请日：2003-04-08

申请人： Timothy Smith ,  M Sydney ,  Hagg Rupert ,  Tommasini Roberto ,  Larcher Yves ,  D Kowell

发明人： Timothy Smith ,  M Sydney ,  Hagg Rupert ,  Tommasini Roberto ,  Larcher Yves ,  D Kowell

IPC分类号： C12N5/08

CPC分类号： C12M21/08 ,  C12M23/28 ,  C12M23/42 ,  C12M23/52 ,  C12M25/14 ,  C12M29/04 ,  C12M41/46 ,  C12M41/48 ,  C12M45/09 ,  C12M47/06 ,  C12M47/12 ,  C12N5/0068 ,  C12N5/0618 ,  C12N5/0654 ,  C12N5/0655 ,  C12N2509/00

摘要： The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.

公开(公告)号：US20060198939A1

公开(公告)日：2006-09-07

申请号：US10490492

申请日：2002-09-24

申请人： Timothy Smith ,  Hendry Jason ,  M Sydney ,  Smith Reginald

发明人： Timothy Smith ,  Hendry Jason ,  M Sydney ,  Smith Reginald

IPC分类号： A61L33/00

CPC分类号： A61L27/46 ,  A61L27/425 ,  A61L27/56 ,  A61L2400/18 ,  B33Y80/00 ,  Y10T428/249967 ,  Y10T428/249978 ,  Y10T428/249979 ,  Y10T428/249981 ,  Y10T428/249987

摘要： The invention relates to porous ceramic composites incorporating biodegradable polymers for use as a bone substitute in the fields of orthopaedics and dentistry or as a scaffold for tissue engineering applications. The porous ceramic composite implant for connective tissue replacement comprises a porous ceramic matrix having a biodegradable polymer provided on internal and external surfaces of the ceramic matrix. The biodegradable polymer allows for the passage and/or delivery of a variety of agents throughout the porous ceramic matrix and improves mechanical properties of the implant in vivo.

摘要翻译： 本发明涉及结合生物可降解聚合物的多孔陶瓷复合材料，其用作骨科和牙科领域的骨替代物或组织工程应用的支架。 用于结缔组织置换的多孔陶瓷复合植入物包括在陶瓷基质的内表面和外表面上提供可生物降解的聚合物的多孔陶瓷基质。 可生物降解的聚合物允许在整个多孔陶瓷基体中通过和/或递送多种试剂，并改善植入物在体内的机械性能。