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公开(公告)号：US08815857B2
公开(公告)日：2014-08-26
申请号：US13570432
申请日：2012-08-09
申请人： Todd Bosanac , Angela Berry , John David Ginn , Tamara Denise Hopkins , Sabine Schlyer , Fariba Soleymanzadeh , John Westbrook , Maolin Yu , Zhonghua Zhang
发明人： Todd Bosanac , Angela Berry , John David Ginn , Tamara Denise Hopkins , Sabine Schlyer , Fariba Soleymanzadeh , John Westbrook , Maolin Yu , Zhonghua Zhang
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D401/04 , C07D401/12 , C07D413/14 , C07D413/12 , C07D417/12 , C07D417/04 , C07D417/14
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08809326B2
公开(公告)日：2014-08-19
申请号：US11856740
申请日：2007-09-18
申请人： Todd Bosanac , John David Ginn , Eugene Richard Hickey , Thomas Martin Kirrane, Jr. , Weimin Liu , Anthony S. Prokopowicz , Sabine K. Schlyer , Cheng-Kon Shih , Roger John Snow , Michael Robert Turner , Frank Wu , Erick Richard Young
发明人： Todd Bosanac , John David Ginn , Eugene Richard Hickey , Thomas Martin Kirrane, Jr. , Weimin Liu , Anthony S. Prokopowicz , Sabine K. Schlyer , Cheng-Kon Shih , Roger John Snow , Michael Robert Turner , Frank Wu , Erick Richard Young
IPC分类号： A61P9/00 , A61P13/00 , A61P15/10 , A61P27/06 , A61P11/06 , C07D217/24 , C07D401/02 , C07D417/02 , C07D239/88 , A61K31/541 , A61K31/4725 , A61K31/472 , C07D239/90 , C07D487/08 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/517 , A61K31/5377 , A61K31/496
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/541 , C07D217/24 , C07D239/88 , C07D239/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/08
摘要： Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.
摘要翻译： 公开了用作Rho激酶抑制剂的新型取代的2H-异喹啉-1-酮和3H-喹唑啉-4-酮衍生物，并用于治疗通过Rho激酶（包括心血管疾病）的活性介导或维持的多种疾病和病症 包含这些化合物的药物组合物，使用这些化合物的方法和制备这些化合物的方法。
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公开(公告)号：US20080161297A1
公开(公告)日：2008-07-03
申请号：US11856740
申请日：2007-09-18
申请人： Todd Bosanac , John David Ginn , Eugene Richard Hickey , Thomas Martin Kirrane , Weimin Liu , Anthony S. Prokopowicz , Sabine K. Schlyer , Cheng-Kon Shih , Roger John Snow , Michael Robert Turner , Frank Wu , Erick Richard Young
发明人： Todd Bosanac , John David Ginn , Eugene Richard Hickey , Thomas Martin Kirrane , Weimin Liu , Anthony S. Prokopowicz , Sabine K. Schlyer , Cheng-Kon Shih , Roger John Snow , Michael Robert Turner , Frank Wu , Erick Richard Young
IPC分类号： A61K31/4725 , A61P9/00 , A61P13/00 , A61P15/10 , A61P27/06 , A61P11/06 , A61K31/517 , A61K31/5377 , A61K31/496 , C07D239/88 , C07D217/24 , C07D401/02 , C07D417/02 , A61K31/541 , A61K31/472
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/541 , C07D217/24 , C07D239/88 , C07D239/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/08
摘要： Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.
摘要翻译： 公开了用作Rho激酶抑制剂的新型取代的2H-异喹啉-1-酮和3H-喹唑啉-4-酮衍生物，并用于治疗通过Rho激酶（包括心血管疾病）的活性介导或维持的多种疾病和病症 包含这些化合物的药物组合物，使用这些化合物的方法和制备这些化合物的方法。
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公开(公告)号：US08895750B2
公开(公告)日：2014-11-25
申请号：US14209280
申请日：2014-03-13
申请人： Todd Bosanac , Michael J. Burke , Darren Disalvo , Wang Mao , John Westbrook
发明人： Todd Bosanac , Michael J. Burke , Darren Disalvo , Wang Mao , John Westbrook
IPC分类号： C07D417/04 , C07D417/14 , C07D487/10 , C07D487/20 , C07D487/22 , C07D487/08 , C07D277/56
CPC分类号： C07D277/56 , C07D417/04 , C07D487/08 , C07D487/10
摘要： The present invention encompasses compounds of the formula (I) wherein the groups ring A and Cy are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
摘要翻译： 本发明包括式（I）化合物，其中环A和Cy基团在本文中定义，其适用于治疗与BTK相关的疾病，制备方法，含有化合物的药物制剂及其使用方法。
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公开(公告)号：US08658661B2
公开(公告)日：2014-02-25
申请号：US13208582
申请日：2011-08-12
申请人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Ho Yin Lo , Pui Leng Loke , Weimin Liu , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Ho Yin Lo , Pui Leng Loke , Weimin Liu , Tina Marie Morwick , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D413/14 , C07D413/10 , C07D417/14 , C07D471/04 , C07D498/04
摘要： The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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6.发明申请Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US20090325988A1
公开(公告)日：2009-12-31
申请号：US12477586
申请日：2009-06-03
申请人： Christian Harcken , Rajashekhar Betageri , Todd Bosanac , Michael Jason Burke , Soojin Kim , Daniel Kuzmich , Thomas Wai-Ho Lee , Zhibin Li , Pingrong Liu , John Lord , Hossein Razavi , Jonathan Timothy Reeves , Daivd Thomson
发明人： Christian Harcken , Rajashekhar Betageri , Todd Bosanac , Michael Jason Burke , Soojin Kim , Daniel Kuzmich , Thomas Wai-Ho Lee , Zhibin Li , Pingrong Liu , John Lord , Hossein Razavi , Jonathan Timothy Reeves , Daivd Thomson
IPC分类号： A61K31/437 , C07D471/04 , C07D211/72 , C07D239/46 , A61K31/44 , A61K31/505 , A61P9/00 , A61P37/08 , A61P17/00 , A61P1/00 , A61P25/00 , A61P35/00 , A61P7/00
CPC分类号： C07D471/04
摘要： Compounds of Formula (I) wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 其中R1，R2，X和Y如本文所定义的式（I）化合物或其互变异构体，旋光异构体，前药，共结晶或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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公开(公告)号：US08580829B2
公开(公告)日：2013-11-12
申请号：US13215654
申请日：2011-08-23
申请人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , Jonathon Alan Dines , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Tina Marie Morwick , Peter Allen Nemoto , Alan Olague , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号： C07D413/14 , A61K31/4245 , C07D413/10 , C07D417/14
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：US08580825B2
公开(公告)日：2013-11-12
申请号：US13237106
申请日：2011-09-20
申请人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
发明人： Alessandra Bartolozzi , Todd Bosanac , Zhidong Chen , Stephane De Lombaert , John D. Huber , Weimin Liu , Ho Yin Lo , Pui Leng Loke , Doris Riether , Heather Tye , Lifen Wu , Renee M. Zindell
CPC分类号： C07D413/14
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US20110275627A1
公开(公告)日：2011-11-10
申请号：US13061996
申请日：2009-08-25
IPC分类号： A61K31/5377 , A61K31/437 , C07D403/14 , A61K31/506 , C07D215/14 , A61P13/12 , C07D413/14 , A61P29/00 , A61P11/00 , A61P37/08 , A61P9/00 , A61P35/00 , C07D471/04 , A61K31/4709
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein X1 to X4, R1 to R4, A, B, D and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中X 1至X 4，R 1至R 4，A，B，D和m如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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10.发明授权Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US08268859B2
公开(公告)日：2012-09-18
申请号：US12477586
申请日：2009-06-03
申请人： Christian Harcken , Rajashekhar Betageri , Todd Bosanac , Michael Jason Burke , Soojin Kim , Daniel Kuzmich , Thomas Wai-ho Lee , Zhibin Li , Pingrong Liu , John Lord , Hossein Razavi , Jonathan Timothy Reeves , David Thomson
发明人： Christian Harcken , Rajashekhar Betageri , Todd Bosanac , Michael Jason Burke , Soojin Kim , Daniel Kuzmich , Thomas Wai-ho Lee , Zhibin Li , Pingrong Liu , John Lord , Hossein Razavi , Jonathan Timothy Reeves , David Thomson
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04
摘要： Compounds of Formula (I) wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 其中R1，R2，X和Y如本文所定义的式（I）化合物或其互变异构体，旋光异构体，前药，共结晶或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
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