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1.发明授权公开(公告)号：US08668924B2
公开(公告)日：2014-03-11
申请号：US12925292
申请日：2010-10-18
CPC分类号： A61F13/0203 , A61F5/40 , A61F13/00063 , A61F13/0253 , A61F13/0256 , A61F13/0276 , A61F13/0289 , A61F13/36 , A61F17/00 , A61F2013/00106 , A61F2013/00221 , A61F2013/00463 , A61F2013/00468 , A61F2013/00472 , A61F2013/0054 , A61F2013/00659 , A61F2013/00676 , A61F2013/0071 , A61F2013/00719 , A61F2013/00931 , A61L15/28 , A61L15/425 , A61L2400/04 , C08L1/00 , C08L5/08
摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe 5 bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof, The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional 10 pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of 15 blood out of the wound site.
摘要翻译： 本发明涉及先进的出血控制伤口敷料，以及其使用和生产方法。 受试者伤口敷料由非哺乳动物材料构成以控制严重的5次出血。 用于控制严重出血的伤口敷料由包含壳聚糖，亲水性聚合物，聚丙烯酸聚合物或其组合的生物材料形成。本发明预期的严重的威胁生命的出血通常是不能被固定的类型 当常规的纱布伤口敷料以常规10压力施加到受试者伤口时。 伤口敷料能够通过粘附到伤口部位上来严重地伤害来自创伤的危及生命的出血的流动，以密封伤口，以加速伤口部位的血块形成，从而加强伤口部位的凝块形成 并且防止从伤口部位渗出，并且基本上禁止15个血液从伤口部位流出。
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2.发明申请Wound dressing and method for controlling severe, life-threatening bleeding 审中-公开伤口敷料和控制严重威胁生命的出血的方法公开(公告)号：US20080213344A1
公开(公告)日：2008-09-04
申请号：US12148320
申请日：2008-04-18
IPC分类号： A61K31/715 , A61L15/00
CPC分类号： A61F13/0203 , A61F5/40 , A61F13/00063 , A61F13/0253 , A61F13/0256 , A61F13/0276 , A61F13/0289 , A61F13/36 , A61F17/00 , A61F2013/00106 , A61F2013/00221 , A61F2013/00463 , A61F2013/00468 , A61F2013/00472 , A61F2013/0054 , A61F2013/00659 , A61F2013/00676 , A61F2013/0071 , A61F2013/00719 , A61F2013/00931 , A61L15/28 , A61L15/425 , A61L2400/04 , C08L1/00 , C08L5/08
摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe 5 bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof, The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional 10 pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of 15 blood out of the wound site.
摘要翻译： 本发明涉及先进的出血控制伤口敷料，以及其使用和生产方法。 受试者伤口敷料由非哺乳动物材料构成以控制严重的5次出血。 用于控制严重出血的伤口敷料由包含壳聚糖，亲水性聚合物，聚丙烯酸聚合物或其组合的生物材料形成。本发明预期的严重的威胁生命的出血通常是不能被固定的类型 当常规的纱布伤口敷料以常规10压力施加到受试者伤口时。 伤口敷料能够通过粘附到伤口部位上来严重地伤害来自创伤的危及生命的出血的流动，以密封伤口，以加速伤口部位的血块形成，从而加强伤口部位的凝块形成 并且防止从伤口部位渗出，并且基本上禁止15个血液从伤口部位流出。
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公开(公告)号：US20080146984A1
公开(公告)日：2008-06-19
申请号：US12002401
申请日：2007-12-17
CPC分类号： A61F13/0276 , A61F13/0223 , A61F13/0226 , A61F17/00 , A61F2013/00472 , A61L15/425
摘要： An aqueous solution of polyacrylic acid is placed in a mold, frozen, and freeze-dried to form a sponge-like polyacrylic acid structure. The sponge-like polyacrylic acid structure is compressed by the application of heat and pressure to reduce the thickness and increase the density of the sponge-like polyacrylic acid structure to form a densified polyacrylic acid structure. The densified polyacrylic acid structure is preconditioned by heating to form a wound dressing. The wound dressing can be applied to control severe, life-threatening bleeding from a wound at a wound site of a person.
摘要翻译： 将聚丙烯酸水溶液置于模具中，冷冻并冷冻干燥以形成海绵状聚丙烯酸结构。 通过施加热和压力来压缩海绵状聚丙烯酸结构以减小厚度并增加海绵状聚丙烯酸结构的密度以形成致密聚丙烯酸结构。 致密聚丙烯酸结构通过加热预处理形成伤口敷料。 伤口敷料可用于控制人身伤口部位伤口严重的危及生命的出血。
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4.发明申请公开(公告)号：US20110034410A1
公开(公告)日：2011-02-10
申请号：US12925292
申请日：2010-10-18
IPC分类号： A61K31/722 , A61P17/02
CPC分类号： A61F13/0203 , A61F5/40 , A61F13/00063 , A61F13/0253 , A61F13/0256 , A61F13/0276 , A61F13/0289 , A61F13/36 , A61F17/00 , A61F2013/00106 , A61F2013/00221 , A61F2013/00463 , A61F2013/00468 , A61F2013/00472 , A61F2013/0054 , A61F2013/00659 , A61F2013/00676 , A61F2013/0071 , A61F2013/00719 , A61F2013/00931 , A61L15/28 , A61L15/425 , A61L2400/04 , C08L1/00 , C08L5/08
摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe 5 bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof, The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional 10 pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of 15 blood out of the wound site.
摘要翻译： 本发明涉及先进的出血控制伤口敷料，以及其使用和生产方法。 受试者伤口敷料由非哺乳动物材料构成以控制严重的5次出血。 用于控制严重出血的伤口敷料由包含壳聚糖，亲水性聚合物，聚丙烯酸聚合物或其组合的生物材料形成。本发明预期的严重的威胁生命的出血通常是不能被固定的类型 当常规的纱布伤口敷料以常规10压力施加到受试者伤口时。 伤口敷料能够通过粘附到伤口部位上来严重地伤害来自创伤的危及生命的出血的流动，以密封伤口，以加速伤口部位的血块形成，从而加强伤口部位的凝块形成 并且防止从伤口部位渗出，并且基本上禁止15个血液从伤口部位流出。
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公开(公告)号：US08313474B2
公开(公告)日：2012-11-20
申请号：US12002401
申请日：2007-12-17
CPC分类号： A61F13/0276 , A61F13/0223 , A61F13/0226 , A61F17/00 , A61F2013/00472 , A61L15/425
摘要： An aqueous solution of polyacrylic acid is placed in a mold, frozen, and freeze-dried to form a sponge-like polyacrylic acid structure. The sponge-like polyacrylic acid structure is compressed by the application of heat and pressure to reduce the thickness and increase the density of the sponge-like polyacrylic acid structure to form a densified polyacrylic acid structure. The densified polyacrylic acid structure is preconditioned by heating to form a wound dressing. The wound dressing can be applied to control severe, life-threatening bleeding from a wound at a wound site of a person.
摘要翻译： 将聚丙烯酸水溶液置于模具中，冷冻并冷冻干燥以形成海绵状聚丙烯酸结构。 通过施加热和压力来压缩海绵状聚丙烯酸结构以减小厚度并增加海绵状聚丙烯酸结构的密度以形成致密聚丙烯酸结构。 致密聚丙烯酸结构通过加热预处理形成伤口敷料。 伤口敷料可用于控制人身伤口部位伤口严重的危及生命的出血。
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6.发明授权公开(公告)号：US07371403B2
公开(公告)日：2008-05-13
申请号：US10743052
申请日：2003-12-23
CPC分类号： A61F13/0203 , A61F5/40 , A61F13/00063 , A61F13/0253 , A61F13/0256 , A61F13/0276 , A61F13/0289 , A61F13/36 , A61F17/00 , A61F2013/00106 , A61F2013/00221 , A61F2013/00463 , A61F2013/00468 , A61F2013/00472 , A61F2013/0054 , A61F2013/00659 , A61F2013/00676 , A61F2013/0071 , A61F2013/00719 , A61F2013/00931 , A61L15/28 , A61L15/425 , A61L2400/04 , C08L1/00 , C08L5/08
摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof. The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of blood out of the wound site.
摘要翻译： 本发明涉及先进的出血控制伤口敷料，以及其使用和生产方法。 受试者伤口敷料由用于控制严重出血的非哺乳动物材料构成。 用于控制严重出血的伤口敷料由包含壳聚糖，亲水性聚合物，聚丙烯酸聚合物或其组合的生物材料形成。 本发明考虑的严重的威胁生命的出血通常是当将传统的纱布伤口敷料以常规压力施加到受试者伤口时不能被切断的类型。 伤口敷料能够通过粘附到伤口部位上来严重地伤害来自创伤的危及生命的出血的流动，以密封伤口，以加速伤口部位的血块形成，从而加强伤口部位的凝块形成 并且防止从伤口部位渗出，并且基本上禁止血液流出伤口部位。
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7.发明申请CHITOSAN-DERIVATIVE COMPOUNDS AND METHODS OF CONTROLLING MICROBIAL POPULATIONS 有权化合物衍生化合物和控制微生物群体的方法公开(公告)号：US20140301955A1
公开(公告)日：2014-10-09
申请号：US14153699
申请日：2014-01-13
IPC分类号： A61K31/722
CPC分类号： C08B37/003 , A61K8/736 , A61K31/722 , A61L2/232 , A61L2/235 , A61L2202/23 , A61L2202/24 , A61Q11/00 , A61Q17/005 , C08L5/08 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/483
摘要： The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments. The present invention is also directed to the control, inhibition and enhancement of microbial populations in animals, particularly humans. The microbial populations include bacteria, viruses and other pathogens where control of microbial populations are a necessity. The chitosan-derivative compounds of the present invention include chitosan-arginine compounds, related chitosan-L/D unnatural amino acid compounds, chitosan-acid amine compounds, chitosan-L/D natural amino acid derivative compounds, co-derivatives of the chitosan-derivative compounds, salts of the chitosan derivative compounds, and chitosan-guanidine compounds.
摘要翻译： 本发明涉及壳聚糖衍生物化合物和结构，制备壳聚糖衍生物化合物的方法以及在各种环境中控制，抑制和增强微生物群体的方法。 本发明还涉及动物，特别是人类中微生物群体的控制，抑制和增强。 微生物种群包括细菌，病毒和其他需要控制微生物群落的病原体。 本发明的壳聚糖衍生物包括壳聚糖 - 精氨酸化合物，壳聚糖-L / D非天然氨基酸化合物，壳聚糖酸胺化合物，壳聚糖-L / D天然氨基酸衍生物化合物，壳聚糖 - 衍生化合物，壳聚糖衍生物化合物的盐和壳聚糖 - 胍化合物。
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8.发明申请METHODS AND COMPOSITIONS OF REDUCING AND PREVENTING BACTERIAL GROWTH AND THE FORMATION OF BIOFILM ON A SURFACE UTILIZING CHITOSAN-DERIVATIVE COMPOUNDS 审中-公开减少和预防细菌生长的方法和组合物和利用酪氨酸衍生化合物的表面上生物素的形成公开(公告)号：US20140221308A1
公开(公告)日：2014-08-07
申请号：US14130253
申请日：2012-06-29
IPC分类号： A01N43/16
CPC分类号： A01N43/16 , A01N47/44 , A23B4/20 , A23L3/3463 , A23L3/3526 , A23L3/3562 , C11D3/227 , C11D3/48
摘要： A method of treating a surface, the method comprising contacting (e.g., spraying) an effective amount of a composition comprising a chitosan (e.g., soluble or derivatized chitosan) with the surface, thereby treating the surface. Non-pharmaceutical compositions (e.g., liquid or dry powder compositions) include chitosan (e.g., a soluble or derivatized chitosan). The compounds and compositions described herein are biocompatible (e.g., non-toxic) and/or biodegradable (e.g., eco-friendly). Methods using the compositions described herein include methods of treating a surface (e.g., an inert and/or non-animal surface, e.g., a synthetic or semi-synthetic surface (e.g., cellulose, ceramic, plastic, metal, glass, wood, or stone); or a food or food product surface, the method comprising contacting (e.g., spraying) an effective amount of a composition comprising a chitosan (e.g., a soluble or derivatized chitosan described herein) with the inert and/or non-animal surface, or the food or food product surface, thereby treating the surface.
摘要翻译： 一种处理表面的方法，该方法包括将有效量的包含壳聚糖（例如可溶性或衍生化壳聚糖）的组合物与表面接触（例如，喷雾），从而处理表面。 非药物组合物（例如液体或干粉组合物）包括壳聚糖（例如，可溶或衍生的壳聚糖）。 本文所述的化合物和组合物是生物相容的（例如，无毒的）和/或可生物降解的（例如，环保的）。 使用本文所述组合物的方法包括处理表面（例如，惰性和/或非动物表面，例如合成或半合成表面（例如纤维素，陶瓷，塑料，金属，玻璃，木材或 石头）;或食品或食品表面，所述方法包括将有效量的包含壳聚糖（例如本文所述的可溶性或衍生化壳聚糖）与惰性和/或非动物表面的组合物（例如，喷雾） ，或食品或食品表面，从而处理表面。
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公开(公告)号：US08399635B2
公开(公告)日：2013-03-19
申请号：US12617349
申请日：2009-11-12
申请人： Shenda Baker , William P. Wiesmann
发明人： Shenda Baker , William P. Wiesmann
CPC分类号： C08B37/003 , A61K31/722 , A61K45/06
摘要： Described herein are methods of inhibiting the growth of or killing a bacterium in an animal subject, preventing or delaying onset of an infection with a bacterium in an animal subject, preventing or delaying onset of a pathogen mediated disease or disorder in an animal subject, or reducing bacterial load in an animal subject, comprising administering an effective amount of a derivatized chitosan to the animal. Also described herein are preparations comprising a chitosan derivative for administration to an animal.
摘要翻译： 本文描述了抑制动物受试者生长或杀死细菌的方法，预防或延迟动物受试者中细菌感染的发生，预防或延迟动物受试者中病原体介导的疾病或病症的发病，或 减少动物受试者的细菌负荷，包括向动物施用有效量的衍生的壳聚糖。 本文还描述了包含用于给予动物的壳聚糖衍生物的制剂。
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10.发明申请CHITOSAN-DERIVATIVE COMPOUNDS AND METHODS OF CONTROLLING MICROBIAL POPULATIONS 有权化合物衍生化合物和控制微生物群体的方法公开(公告)号：US20120329753A1
公开(公告)日：2012-12-27
申请号：US13324461
申请日：2011-12-13
申请人： Shenda Baker , William P. Wiesmann , Shannon Ryan
发明人： Shenda Baker , William P. Wiesmann , Shannon Ryan
IPC分类号： C08B37/08 , A61P31/04 , A61K31/722
CPC分类号： C08B37/003 , A61K8/736 , A61K31/722 , A61L2/232 , A61L2/235 , A61L2202/23 , A61L2202/24 , A61Q11/00 , A61Q17/005 , C08L5/08 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/483
摘要： The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments. The present invention is also directed to the control, inhibition and enhancement of microbial populations in animals, particularly humans. The microbial populations include bacteria, viruses and other pathogens where control of microbial populations are a necessity. The chitosan-derivative compounds of the present invention include chitosan-arginine compounds, related chitosan-L/D unnatural amino acid compounds, chitosan-acid amine compounds, chitosan-L/D natural amino acid derivative compounds, co-derivatives of the chitosan-derivative compounds, salts of the chitosan derivative compounds, and chitosan-guanidine compounds.
摘要翻译： 本发明涉及壳聚糖衍生物化合物和结构，制备壳聚糖衍生物化合物的方法以及在各种环境中控制，抑制和增强微生物群体的方法。 本发明还涉及动物，特别是人的微生物群体的控制，抑制和增强。 微生物种群包括细菌，病毒和其他需要控制微生物群落的病原体。 本发明的壳聚糖衍生物包括壳聚糖 - 精氨酸化合物，壳聚糖-L / D非天然氨基酸化合物，壳聚糖酸胺化合物，壳聚糖-L / D天然氨基酸衍生物化合物，壳聚糖 - 衍生化合物，壳聚糖衍生物化合物的盐和壳聚糖 - 胍化合物。
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