公开(公告)号：US09012429B2

公开(公告)日：2015-04-21

申请号：US12541584

申请日：2009-08-14

申请人： Shenda Baker ,  William P. Wiesmann

发明人： Shenda Baker ,  William P. Wiesmann

IPC分类号： A61K31/722

CPC分类号： A61K31/722

摘要： The present invention is directed to the treatment and prevention of nosocomial infections or MRSA infections utilizing soluble chitosan or chitosan derivative compounds. These chitosan-derivative compounds, e.g., chitosan-arginine and chitosan-acid amines, exhibit bactericidal activity against bacterial pathogens, e.g., drug resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA).

摘要翻译： 本发明涉及利用可溶性壳聚糖或壳聚糖衍生物化合物治疗和预防医院感染或MRSA感染。 这些壳聚糖衍生物化合物，例如壳聚糖 - 精氨酸和壳聚糖酸胺，对细菌病原体，例如抗药性细菌如耐甲氧西林金黄色葡萄球菌（MRSA）表现出杀菌活性。

公开(公告)号：US08658775B2

公开(公告)日：2014-02-25

申请号：US13324461

申请日：2011-12-13

申请人： Shenda Baker ,  William P. Wiesmann ,  Shannon Ryan

发明人： Shenda Baker ,  William P. Wiesmann ,  Shannon Ryan

IPC分类号： C08B37/08 ,  A01N43/04

CPC分类号： C08B37/003 ,  A61K8/736 ,  A61K31/722 ,  A61L2/232 ,  A61L2/235 ,  A61L2202/23 ,  A61L2202/24 ,  A61Q11/00 ,  A61Q17/005 ,  C08L5/08 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/483

摘要： The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments. The present invention is also directed to the control, inhibition and enhancement of microbial populations in animals, particularly humans. The microbial populations include bacteria, viruses and other pathogens where control of microbial populations are a necessity. The chitosan-derivative compounds of the present invention include chitosan-arginine compounds, related chitosan-L/D unnatural amino acid compounds, chitosan-acid amine compounds, chitosan-L/D natural amino acid derivative compounds, co-derivatives of the chitosan-derivative compounds, salts of the chitosan derivative compounds, and chitosan-guanidine compounds.

摘要翻译： 本发明涉及壳聚糖衍生物化合物和结构，制备壳聚糖衍生物化合物的方法以及在各种环境中控制，抑制和增强微生物群体的方法。 本发明还涉及动物，特别是人的微生物群体的控制，抑制和增强。 微生物种群包括细菌，病毒和其他需要控制微生物群落的病原体。 本发明的壳聚糖衍生物包括壳聚糖 - 精氨酸化合物，壳聚糖-L / D非天然氨基酸化合物，壳聚糖酸胺化合物，壳聚糖-L / D天然氨基酸衍生物化合物，壳聚糖 - 衍生化合物，壳聚糖衍生物化合物的盐和壳聚糖 - 胍化合物。

公开(公告)号：US20120301408A1

公开(公告)日：2012-11-29

申请号：US13411208

申请日：2012-03-02

申请人： Shenda Baker ,  William P. Wiesmann ,  Stacy M. Townsend

发明人： Shenda Baker ,  William P. Wiesmann ,  Stacy M. Townsend

IPC分类号： A61K8/73 ,  A61P31/04 ,  A61Q11/00 ,  A61P1/02 ,  A61K31/722 ,  C08B37/08

CPC分类号： A61K8/736 ,  A61K2800/30 ,  A61Q11/00 ,  A61Q11/02 ,  A61Q17/005

摘要： Described herein is a method of reducing bacteria in the mouth of a subject, the method comprising contacting (e.g., rinsing) the mouth with an effective amount of a composition comprising a soluble derivatized chitosan, thereby reducing bacteria in the mouth of the subject.

摘要翻译： 本文描述的是减少受试者口腔中的细菌的方法，该方法包括使口部接触（例如，漂洗）有效量的包含可溶性衍生化壳聚糖的组合物，从而减少受试者口腔中的细菌。

公开(公告)号：US07721736B2

公开(公告)日：2010-05-25

申请号：US11446832

申请日：2006-06-05

申请人： Adrian Urias ,  Loland A. Pranger ,  William P. Wiesmann ,  Earl Smith

发明人： Adrian Urias ,  Loland A. Pranger ,  William P. Wiesmann ,  Earl Smith

IPC分类号： A61M16/00

CPC分类号： A61M16/0063 ,  A61M16/0009 ,  A61M16/0051 ,  A61M16/022 ,  A61M16/0858 ,  A61M16/107 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2016/0413 ,  A61M2205/16 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/8206 ,  A61M2230/432 ,  A62B99/00

摘要： The portable ventilator of the present invention provides a hands-free ventilatory support device in critical care, emergency, and resource-limited environments. The portable ventilator utilizes ambient air and includes a two dual head compressor system to provide a consistent air supply to the patient. The ventilator device is battery operated and is capable of providing up to 60 minutes of care. In a preferred embodiment, the portable ventilator of the present invention also includes a pneumatic subsystem, a control subsystem, a power subsystem and an alarm subsystem. The portable ventilator of the preferred embodiment includes a dual head and single head compressor system that operates alternatively, to provide a consistent and continuous inhalation and exhalation cycle. A portable ventilator of a second preferred embodiment includes a sole dual-head compressor that operates to provide a consistent and continuous inhalation and exhalation cycle.

摘要翻译： 本发明的便携式呼吸机在重症监护，紧急和资源有限的环境中提供免提通气支持装置。 便携式呼吸机利用环境空气，并且包括两个双头压缩机系统，以向患者提供一致的空气供应。 呼吸机设备是电池供电的，能够提供长达60分钟的护理。 在优选实施例中，本发明的便携式呼吸机还包括气动子系统，控制子系统，电力子系统和警报子系统。 优选实施例的便携式呼吸机包括双头和单头压缩机系统，其可选地操作，以提供一致且连续的吸入和呼气循环。 第二优选实施例的便携式呼吸机包括唯一的双头压缩机，其操作以提供一致且连续的吸入和呼气循环。

公开(公告)号：US20080213344A1

公开(公告)日：2008-09-04

申请号：US12148320

申请日：2008-04-18

申请人： Simon J. McCarthy ,  Kenton W. Gregory ,  William P. Wiesmann ,  Todd D. Campbell

发明人： Simon J. McCarthy ,  Kenton W. Gregory ,  William P. Wiesmann ,  Todd D. Campbell

IPC分类号： A61K31/715 ,  A61L15/00

CPC分类号： A61F13/0203 ,  A61F5/40 ,  A61F13/00063 ,  A61F13/0253 ,  A61F13/0256 ,  A61F13/0276 ,  A61F13/0289 ,  A61F13/36 ,  A61F17/00 ,  A61F2013/00106 ,  A61F2013/00221 ,  A61F2013/00463 ,  A61F2013/00468 ,  A61F2013/00472 ,  A61F2013/0054 ,  A61F2013/00659 ,  A61F2013/00676 ,  A61F2013/0071 ,  A61F2013/00719 ,  A61F2013/00931 ,  A61L15/28 ,  A61L15/425 ,  A61L2400/04 ,  C08L1/00 ,  C08L5/08

摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe 5 bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof, The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional 10 pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of 15 blood out of the wound site.

摘要翻译： 本发明涉及先进的出血控制伤口敷料，以及其使用和生产方法。 受试者伤口敷料由非哺乳动物材料构成以控制严重的5次出血。 用于控制严重出血的伤口敷料由包含壳聚糖，亲水性聚合物，聚丙烯酸聚合物或其组合的生物材料形成。本发明预期的严重的威胁生命的出血通常是不能被固定的类型 当常规的纱布伤口敷料以常规10压力施加到受试者伤口时。 伤口敷料能够通过粘附到伤口部位上来严重地伤害来自创伤的危及生命的出血的流动，以密封伤口，以加速伤口部位的血块形成，从而加强伤口部位的凝块形成 并且防止从伤口部位渗出，并且基本上禁止15个血液从伤口部位流出。

公开(公告)号：US20080146984A1

公开(公告)日：2008-06-19

申请号：US12002401

申请日：2007-12-17

申请人： Todd D. Campbell ,  William P. Wiesmann ,  Simon J. McCarthy

发明人： Todd D. Campbell ,  William P. Wiesmann ,  Simon J. McCarthy

IPC分类号： A61F13/02 ,  B29C35/02

CPC分类号： A61F13/0276 ,  A61F13/0223 ,  A61F13/0226 ,  A61F17/00 ,  A61F2013/00472 ,  A61L15/425

摘要： An aqueous solution of polyacrylic acid is placed in a mold, frozen, and freeze-dried to form a sponge-like polyacrylic acid structure. The sponge-like polyacrylic acid structure is compressed by the application of heat and pressure to reduce the thickness and increase the density of the sponge-like polyacrylic acid structure to form a densified polyacrylic acid structure. The densified polyacrylic acid structure is preconditioned by heating to form a wound dressing. The wound dressing can be applied to control severe, life-threatening bleeding from a wound at a wound site of a person.

摘要翻译： 将聚丙烯酸水溶液置于模具中，冷冻并冷冻干燥以形成海绵状聚丙烯酸结构。 通过施加热和压力来压缩海绵状聚丙烯酸结构以减小厚度并增加海绵状聚丙烯酸结构的密度以形成致密聚丙烯酸结构。 致密聚丙烯酸结构通过加热预处理形成伤口敷料。 伤口敷料可用于控制人身伤口部位伤口严重的危及生命的出血。

公开(公告)号：US06848444B2

公开(公告)日：2005-02-01

申请号：US09920431

申请日：2001-07-31

申请人： Dexter G. Smith ,  Protagoras N. Cutchis ,  William P. Wiesmann ,  Loland A. Pranger

发明人： Dexter G. Smith ,  Protagoras N. Cutchis ,  William P. Wiesmann ,  Loland A. Pranger

IPC分类号： A61M1/00 ,  A61M16/00

CPC分类号： A61M16/0063 ,  A61M1/0066 ,  A61M16/0051 ,  A61M16/024 ,  A61M2016/0039 ,  A61M2205/16 ,  A61M2205/3553 ,  A61M2205/3576 ,  A61M2205/8206 ,  A61M2205/8225 ,  A61M2230/205 ,  A61M2230/432 ,  G06F19/00

摘要： An emergency life support system including a patient ventilator for mechanical breathing assistance; a capnograph to monitor CO2 for ventilation effectiveness; a pulse oximeter for measuring blood stream oxygen saturation; a carbon dioxide sensor; an electrocardiograph (ECG) to monitor cardiac performance; an infusion pump; and alarms and a data recorder. The preferred embodiment uses an oxygen generator to deliver oxygen, to generate electric power to run the ventilation system, and to warm IV fluids and resuscitated air. The generator has electronically controlled valves and a modified valve system that offers the ability to select the oxygen concentration in the air delivered to the patient.

摘要翻译： 包括用于机械呼吸辅助的患者呼吸机的紧急生命支援系统; 一个监测二氧化碳通气效能的呼吸监测仪; 用于测量血流氧饱和度的脉搏血氧计; 二氧化碳传感器; 心电图仪（ECG）以监测心脏的表现; 输液泵 报警和数据记录器。 优选实施例使用氧气发生器来输送氧气，产生电力以运行通风系统，并且使IV液体和复苏的空气变暖。 发电机具有电子控制阀和改进的阀系统，其提供选择输送到患者的空气中的氧浓度的能力。

公开(公告)号：US20140301955A1

公开(公告)日：2014-10-09

申请号：US14153699

申请日：2014-01-13

申请人： Shenda M. Baker ,  William P. Wiesmann

发明人： Shenda M. Baker ,  William P. Wiesmann

IPC分类号： A61K31/722

CPC分类号： C08B37/003 ,  A61K8/736 ,  A61K31/722 ,  A61L2/232 ,  A61L2/235 ,  A61L2202/23 ,  A61L2202/24 ,  A61Q11/00 ,  A61Q17/005 ,  C08L5/08 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/483

摘要： The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments. The present invention is also directed to the control, inhibition and enhancement of microbial populations in animals, particularly humans. The microbial populations include bacteria, viruses and other pathogens where control of microbial populations are a necessity. The chitosan-derivative compounds of the present invention include chitosan-arginine compounds, related chitosan-L/D unnatural amino acid compounds, chitosan-acid amine compounds, chitosan-L/D natural amino acid derivative compounds, co-derivatives of the chitosan-derivative compounds, salts of the chitosan derivative compounds, and chitosan-guanidine compounds.

摘要翻译： 本发明涉及壳聚糖衍生物化合物和结构，制备壳聚糖衍生物化合物的方法以及在各种环境中控制，抑制和增强微生物群体的方法。 本发明还涉及动物，特别是人类中微生物群体的控制，抑制和增强。 微生物种群包括细菌，病毒和其他需要控制微生物群落的病原体。 本发明的壳聚糖衍生物包括壳聚糖 - 精氨酸化合物，壳聚糖-L / D非天然氨基酸化合物，壳聚糖酸胺化合物，壳聚糖-L / D天然氨基酸衍生物化合物，壳聚糖 - 衍生化合物，壳聚糖衍生物化合物的盐和壳聚糖 - 胍化合物。

公开(公告)号：US20140221308A1

公开(公告)日：2014-08-07

申请号：US14130253

申请日：2012-06-29

申请人： Shenda Baker ,  William P. Wiesmann ,  Stacy M. Townsend

发明人： Shenda Baker ,  William P. Wiesmann ,  Stacy M. Townsend

IPC分类号： A01N43/16

CPC分类号： A01N43/16 ,  A01N47/44 ,  A23B4/20 ,  A23L3/3463 ,  A23L3/3526 ,  A23L3/3562 ,  C11D3/227 ,  C11D3/48

摘要： A method of treating a surface, the method comprising contacting (e.g., spraying) an effective amount of a composition comprising a chitosan (e.g., soluble or derivatized chitosan) with the surface, thereby treating the surface. Non-pharmaceutical compositions (e.g., liquid or dry powder compositions) include chitosan (e.g., a soluble or derivatized chitosan). The compounds and compositions described herein are biocompatible (e.g., non-toxic) and/or biodegradable (e.g., eco-friendly). Methods using the compositions described herein include methods of treating a surface (e.g., an inert and/or non-animal surface, e.g., a synthetic or semi-synthetic surface (e.g., cellulose, ceramic, plastic, metal, glass, wood, or stone); or a food or food product surface, the method comprising contacting (e.g., spraying) an effective amount of a composition comprising a chitosan (e.g., a soluble or derivatized chitosan described herein) with the inert and/or non-animal surface, or the food or food product surface, thereby treating the surface.

摘要翻译： 一种处理表面的方法，该方法包括将有效量的包含壳聚糖（例如可溶性或衍生化壳聚糖）的组合物与表面接触（例如，喷雾），从而处理表面。 非药物组合物（例如液体或干粉组合物）包括壳聚糖（例如，可溶或衍生的壳聚糖）。 本文所述的化合物和组合物是生物相容的（例如，无毒的）和/或可生物降解的（例如，环保的）。 使用本文所述组合物的方法包括处理表面（例如，惰性和/或非动物表面，例如合成或半合成表面（例如纤维素，陶瓷，塑料，金属，玻璃，木材或 石头）;或食品或食品表面，所述方法包括将有效量的包含壳聚糖（例如本文所述的可溶性或衍生化壳聚糖）与惰性和/或非动物表面的组合物（例如，喷雾） ，或食品或食品表面，从而处理表面。

公开(公告)号：US08668924B2

公开(公告)日：2014-03-11

申请号：US12925292

申请日：2010-10-18

申请人： Simon J. McCarthy ,  Kenton W. Gregory ,  William P. Wiesmann ,  Todd D. Campbell

发明人： Simon J. McCarthy ,  Kenton W. Gregory ,  William P. Wiesmann ,  Todd D. Campbell

IPC分类号： A61F13/02 ,  A61L15/00 ,  C08B37/08 ,  A61F13/00 ,  C08L1/00 ,  A61L15/28 ,  A61L15/42

CPC分类号： A61F13/0203 ,  A61F5/40 ,  A61F13/00063 ,  A61F13/0253 ,  A61F13/0256 ,  A61F13/0276 ,  A61F13/0289 ,  A61F13/36 ,  A61F17/00 ,  A61F2013/00106 ,  A61F2013/00221 ,  A61F2013/00463 ,  A61F2013/00468 ,  A61F2013/00472 ,  A61F2013/0054 ,  A61F2013/00659 ,  A61F2013/00676 ,  A61F2013/0071 ,  A61F2013/00719 ,  A61F2013/00931 ,  A61L15/28 ,  A61L15/425 ,  A61L2400/04 ,  C08L1/00 ,  C08L5/08

摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe 5 bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof, The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional 10 pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of 15 blood out of the wound site.

摘要翻译： 本发明涉及先进的出血控制伤口敷料，以及其使用和生产方法。 受试者伤口敷料由非哺乳动物材料构成以控制严重的5次出血。 用于控制严重出血的伤口敷料由包含壳聚糖，亲水性聚合物，聚丙烯酸聚合物或其组合的生物材料形成。本发明预期的严重的威胁生命的出血通常是不能被固定的类型 当常规的纱布伤口敷料以常规10压力施加到受试者伤口时。 伤口敷料能够通过粘附到伤口部位上来严重地伤害来自创伤的危及生命的出血的流动，以密封伤口，以加速伤口部位的血块形成，从而加强伤口部位的凝块形成 并且防止从伤口部位渗出，并且基本上禁止15个血液从伤口部位流出。