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公开(公告)号:US06265605B1
公开(公告)日:2001-07-24
申请号:US09499699
申请日:2000-02-07
申请人: Todd J. Johnson , Michael K. Stern , David A. Morgenstern , Michael D. Rogers , Yvette M. Fobian , Jeffrey A. Levine
发明人: Todd J. Johnson , Michael K. Stern , David A. Morgenstern , Michael D. Rogers , Yvette M. Fobian , Jeffrey A. Levine
IPC分类号: C07F938
CPC分类号: C07F9/3813 , C07C227/00 , C07C275/16 , C07D241/18 , C07D251/04 , C07D251/14
摘要: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.
摘要翻译: 新型化合物,N,N'-双(膦酰基甲基)-N,N'-双(羟基羰基甲基)脲和N,N,N',N'-四(羟基羰基甲基)脲,适用于制备N-酰基氨基羧酸 可以容易地转化成N-(膦酰基甲基)甘氨酸。 这些化合物可以通过在羧甲基化催化剂前体和溶剂的存在下分别与双 - (phosophonomethyl)脲或脲与一氧化碳和甲醛的反应形成。
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公开(公告)号:US6153753A
公开(公告)日:2000-11-28
申请号:US22967
申请日:1998-02-12
申请人: Todd J. Johnson , Michael K. Stern , David A. Morgenstern , Michael D. Rogers , Yvette M. Fobian , Jeffrey A. Levine
发明人: Todd J. Johnson , Michael K. Stern , David A. Morgenstern , Michael D. Rogers , Yvette M. Fobian , Jeffrey A. Levine
IPC分类号: B01J31/24 , B01J31/20 , C07B61/00 , C07C227/00 , C07C227/20 , C07C229/16 , C07C231/08 , C07C233/36 , C07C233/47 , C07C273/18 , C07C275/16 , C07D241/08 , C07D241/18 , C07D251/04 , C07D251/14 , C07F9/38 , C07F9/40 , C07F9/6509
CPC分类号: C07F9/3813 , C07C227/00 , C07C275/16 , C07D241/18 , C07D251/04 , C07D251/14
摘要: Process for the preparation of an N-acyl amino carboxylic acid by means of a carboxymethylation reaction. In this reaction, a reaction mixture is formed which contains a base pair, carbon monoxide, hydrogen and an aldehyde with the base pair comprising a carbamoyl compound and a carboxymethylation catalyst precursor. In a preferred embodiment, the carbamoyl compound and aldehyde are selected to yield an N-acyl amino carboxylic acid which is readily converted to N-(phosphonomethyl)glycine, or a salt or ester thereof.
摘要翻译: 通过羧甲基化反应制备N-酰基氨基羧酸的方法。 在该反应中,形成含有碱基对,一氧化碳,氢和醛的反应混合物,碱基对包含氨基甲酰基化合物和羧甲基化催化剂前体。 在优选的实施方案中,选择氨基甲酰基化合物和醛以产生N-酰基氨基羧酸,其易于转化为N-(膦酰基甲基)甘氨酸或其盐或酯。
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公开(公告)号:US4707491A
公开(公告)日:1987-11-17
申请号:US811919
申请日:1985-12-20
IPC分类号: A61K31/38 , A61K31/381 , A61P25/08 , C07D333/32
CPC分类号: A61K31/38 , C07D333/32
摘要: .gamma.-Thiobutyrolactone derivatives having short chain .alpha.- and/or .gamma.-alkyl or alkenyl substituents have useful anticonvulsant properties.
摘要翻译: 具有短链α-和/或γ-烷基或烯基取代基的γ-硫代丁内酯衍生物具有有用的抗惊厥性质。
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公开(公告)号:US5264204A
公开(公告)日:1993-11-23
申请号:US876548
申请日:1992-04-30
IPC分类号: A61K49/20 , C07D207/46 , G01R33/28 , G01N24/08 , A61K31/40 , A61K31/415
CPC分类号: G01R33/5601 , A61K49/20 , C07D207/46 , Y10T436/24
摘要: Methods and compositions are disclosed for enhancing magnetic resonance imaging which utilize hydrophilic free radical compounds as magnetic resonance contrast media. Typical magnetic resonance contrast media within the scope of the present invention include stable hydrophilic free radicals having a hydrophilic moiety, such as polyhydroxyalkyl groups and heterocyclic amino-alcohols such as dihydroxypyrrolidine, dihydroxypiperidine, and trihydroxypiperidine, and a stable free radical moiety, such as a nitroxide, phenoxy, or phenoxazinyl free radical moiety.
摘要翻译: 公开了用于增强使用亲水性自由基化合物作为磁共振造影剂的磁共振成像的方法和组合物。 在本发明范围内的典型磁共振造影剂包括具有亲水部分的稳定的亲水性自由基,例如聚羟基烷基和杂环氨基醇,例如二羟基吡咯烷,二羟基哌啶和三羟基哌啶,以及稳定的自由基部分,例如 硝基氧,苯氧基或吩恶嗪基自由基部分。
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公开(公告)号:US4621591A
公开(公告)日:1986-11-11
申请号:US719697
申请日:1985-04-04
CPC分类号: A01K27/002 , A01K25/00 , A01K27/00
摘要: A combination collar and muzzle is used as a humane method of restraining, controlling, and achieving obedient behavior of animals, dogs in particular. A collar member or loop encircles the neck immediately behind the ears, and a second loop encircles the upper and lower jaws of the animal to form a type of a figure eight combination collar and muzzle. The two loops are coupled together with a ring behind the jaw. The loops are slidably connected so that when a leash is attached to the portion of the muzzle loop extending out from the connecting ring it will slide easily and at the same time will exert a downward pressure on the neck immediately behind the ears. Pressure is thus simultaneously applied to nerves and muscles tending to control the dog humanely and without choking or applying pressure to the trachea and larynx. The simultaneous pressure serves to calm and control the dog in a precise and effective manner without injury or choking and achieves precise, active and effective control and calmness without injuring the dog.
摘要翻译: 组合衣领和枪口被用作限制,控制和实现动物,特别是狗的顺从行为的人道的方法。 颈圈成员或环圈紧紧地在耳后面包围颈部,第二回路围绕动物的上下爪,以形成一种图8组合领和枪口。 两个环通过颚后面的环连接在一起。 环可滑动地连接,使得当皮带附接到从连接环延伸出的枪口环的部分时,它将容易滑动,并且同时将在耳后立即施加向下的压力。 因此,压力同时应用于神经和肌肉,其趋于人性地控制狗,并且不会对气管和喉部产生窒息或施加压力。 同时的压力有助于平静和控制狗的精确和有效的方式没有受伤或窒息,并实现精确,主动和有效的控制和平静,而不会伤害狗。
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公开(公告)号:US07521403B2
公开(公告)日:2009-04-21
申请号:US11222198
申请日:2005-09-08
申请人: Jeffrey A. Levine , Si Wu
发明人: Jeffrey A. Levine , Si Wu
IPC分类号: C10M173/02
CPC分类号: C10M133/16 , C07C237/06 , C10M2215/08 , C10N2230/06 , C10N2230/42 , C10N2230/43 , C10N2230/45
摘要: Alkylamine, alkylenedi-, alkylenetri- or alkylenetetra-amine derivatives of N-alkyl-halo-acetamides, are useful as ashless, phosphorus-free and sulfur-free antiwear and friction modifying additives for lubricating oils. The additives are of the formula (I), (II) or (III) where A is alkylene of from 2 to 6 carbon atoms or is a group G, each independently, is alkylene of 2 to 6 carbon atoms, R, each independently, is alkyl or alkenyl of 1 to 8 carbon atoms and R′, each independently, is hydrogen or alkyl or alkenyl or 1 to 24 carbon atoms, where if an amide nitrogen is monosubstituted by alkyl or alkenyl, said alkyl or alkenyl is from 8 to 24 carbon atoms, where if an amide nitrogen is disubstituted by alkyl or alkenyl, the total carbon atoms of said alkyls or alkenyls combined are from 8 to 18 carbon atoms, and where each amide nitrogen is either mono- or disubstituted by alkyl or alkenyl.
摘要翻译: N-烷基 - 卤代 - 乙酰胺的烷基胺,亚烷基二亚胺,亚烷基三烷基或亚烷基四胺衍生物可用作润滑油的无灰,无磷和无硫抗磨损和摩擦改性添加剂。 添加剂具有式(I),(II)或(III),其中A是2至6个碳原子的亚烷基或基团G,各自独立地是2至6个碳原子的亚烷基,R各自独立地 是1至8个碳原子的烷基或烯基,R'各自独立地是氢或烷基或烯基或1至24个碳原子,其中如果酰胺氮被烷基或烯基单取代,则所述烷基或链烯基是8 至24个碳原子,其中如果酰胺氮被烷基或烯基二取代,则所述烷基或烯基的总碳原子数为8至18个碳原子,并且其中每个酰胺氮被烷基或烯基单取代或二取代 。
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公开(公告)号:US07291581B2
公开(公告)日:2007-11-06
申请号:US10848303
申请日:2004-05-18
申请人: Jeffrey A. Levine , Si Wu
发明人: Jeffrey A. Levine , Si Wu
IPC分类号: C10M169/06 , C10M125/26 , C07F5/02
CPC分类号: C07F5/04 , C10M139/00 , C10M141/12 , C10M2227/061 , C10N2230/06 , C10N2240/06 , C10N2240/40
摘要: Disclosed are borate and boronate compounds of the formulae where R1, R2 and R3 are independently hydrogen, straight or branched chain alkyl of 1 to 24 carbon atoms, straight or branched chain alkenyl of 2 to 24 carbon atoms, cycloalkyl of 5 to 12 carbon atoms, aryl of 6 to 10 carbon atoms, aralkyl of 7 to 15 carbon atoms, alkaryl of 7 to 15 carbon atoms; Ar is substituted or unsubstituted aryl of 6 to 10 carbon atoms; and R4 and R5 are independently defined as for R1 and may also be hydroxyphenyl or alkylated hydroxyphenyl, or R4 and R5 together with the —OBO— group form a substituted or unsubstituted 5 or 6 membered ring. The borate and boronate compounds are effective as antiwear, extreme pressure, and friction modifying additives for lubricating oils and fuels.
摘要翻译: 公开了下式的硼酸酯和硼酸酯化合物,其中R 1,R 2和R 3 3独立地是氢,1或1的直链或支链烷基 至24个碳原子,2至24个碳原子的直链或支链烯基,5至12个碳原子的环烷基,6至10个碳原子的芳基,7至15个碳原子的芳烷基,7至15个碳原子的烷芳基; Ar为6-10个碳原子的取代或未取代的芳基; R 4和R 5独立地定义为R 1,并且也可以是羟基苯基或烷基化羟基苯基,或R 4, / SUB和R 5与-OBO基一起形成取代或未取代的5或6元环。 硼酸盐和硼酸盐化合物作为抗磨损,极压和用于润滑油和燃料的摩擦改性添加剂是有效的。
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公开(公告)号:US4838206A
公开(公告)日:1989-06-13
申请号:US169294
申请日:1988-03-17
CPC分类号: A01K27/002 , A01K25/00 , A01K27/00
摘要: A combination collar and muzzle is used as a humane method of restraining, controlling, and achieving obedient behavior of animals, dogs in particular. A collar member or loop encircles the neck immediately behind the ears, and a second muzzle loop encircles the upper and lower jaws of the animal to form a type of a figure eight combination collar and muzzle. The two loops are coupled together with a ring behind the jaw. The muzzle loop is adjustable in length. An optional adjustable keeper strap is connected between the collar loop and the muzzle loop to retain the muzzle loop from being pawed off.
摘要翻译: 组合衣领和枪口被用作限制,控制和实现动物,特别是狗的顺从行为的人道的方法。 颈圈成员或环圈紧紧地在耳朵后面包围颈部,第二个枪口环围绕动物的上下爪形成一个图形8组合领和枪口。 两个环通过颚后面的环连接在一起。 枪口回路长度可调。 一个可选的可调整的保持器带连接在套环环和枪口环之间,以保持枪口环不被卡止。
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公开(公告)号:US4741288A
公开(公告)日:1988-05-03
申请号:US922156
申请日:1986-10-23
CPC分类号: A01K27/002 , A01K25/00 , A01K27/00
摘要: A combination collar and muzzle is used as a humane method of restraining, controlling, and achieving obedient behavior of animals, dogs in particular. A collar member or loop encircles the neck immediately behind the ears, and a second muzzle loop encircles the upper and lower jaws of the animal to form a type of a figure eight combination collar and muzzle. The two loops are coupled together with a ring behind the jaw. The muzzle loop is adjustable in length. An optional adjustable keeper strap is connected between the collar loop and the muzzle loop to retain the muzzle loop from being pawed off.
摘要翻译: 组合衣领和枪口被用作限制,控制和实现动物,特别是狗的顺从行为的人道的方法。 颈圈成员或环圈紧紧地在耳朵后面包围颈部,第二个枪口环围绕动物的上下爪形成一个图形8组合领和枪口。 两个环通过颚后面的环连接在一起。 枪口回路长度可调。 一个可选的可调整的保持器带连接在套环环和枪口环之间,以保持枪口环不被卡止。
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