公开(公告)号：US09804174B2

公开(公告)日：2017-10-31

申请号：US15119645

申请日：2015-02-13

申请人： TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE

发明人： Noriyuki Matsuda ,  Fumika Koyano ,  Kei Okatsu ,  Etsu Go ,  Mayumi Kimura ,  Yasushi Saeki

IPC分类号： C07K16/18 ,  G01N33/68 ,  C07K14/47 ,  C12Q1/48 ,  G01N33/50 ,  A61K38/00

CPC分类号： G01N33/6896 ,  A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/485 ,  C12Y207/11001 ,  G01N33/5079 ,  G01N2333/47 ,  G01N2333/912 ,  G01N2333/91215 ,  G01N2440/14 ,  G01N2500/00 ,  G01N2500/20 ,  G01N2800/2835

摘要： A antibody has as a target molecule a ubiquitin protein comprising a phosphorylated serine residue at position 65. In addition, a method is provided for specifically detecting Parkinson's disease at an early stage, in which a target molecule is a ubiquitin protein comprising a phosphorylated serine residue at position 65, a pharmaceutical composition for definitively treating or preventing Parkinson's disease, and a method for screening for the pharmaceutical composition.

公开(公告)号：US20180045741A1

公开(公告)日：2018-02-15

申请号：US15725712

申请日：2017-10-05

申请人： Tokyo Metropolitan Institute of Medical Science

发明人： Noriyuki Matsuda ,  Fumika Koyano ,  Kei Okatsu ,  Etsu Go ,  Mayumi Kimura ,  Yasushi Saeki

IPC分类号： G01N33/68 ,  C12Q1/48 ,  G01N33/50 ,  C07K14/47 ,  C07K16/18 ,  A61K38/00

CPC分类号： G01N33/6896 ,  A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/485 ,  C12Y207/11001 ,  G01N33/5079 ,  G01N2333/47 ,  G01N2333/912 ,  G01N2333/91215 ,  G01N2440/14 ,  G01N2500/00 ,  G01N2500/20 ,  G01N2800/2835

摘要： An antibody has as a target molecule a ubiquitin protein comprising a phosphorylated serine residue at position 65. In addition, a method is provided for specifically detecting Parkinson's disease at an early stage, in which a target molecule is a ubiquitin protein comprising a phosphorylated serine residue at position 65, a pharmaceutical composition for definitively treating or preventing Parkinson's disease, and a method for screening for the pharmaceutical composition.