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    Pyridine derivatives and pyrimidine derivatives (3)
    5.
    发明授权
    Pyridine derivatives and pyrimidine derivatives (3) 有权
    吡啶衍生物和嘧啶衍生物（3）

    公开(公告)号：US07855290B2

    公开(公告)日：2010-12-21

    申请号：US11508322

    申请日：2006-08-23

    申请人： Tomohiro Matsushima ,  Keiko Takahashi ,  Setsuo Funasaka ,  Shuji Shirotori

    发明人： Tomohiro Matsushima ,  Keiko Takahashi ,  Setsuo Funasaka ,  Shuji Shirotori

    IPC分类号： C07D213/75 ,  C07D239/47 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

    CPC分类号： C07D401/12 ,  C07D213/75 ,  C07D239/47 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    摘要： A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents —CH═, nitrogen or the like.]

    摘要翻译： 由下式表示的化合物，其盐或其水合物具有优异的肝细胞生长因子受体（HGFR）抑制活性，具有抗肿瘤活性，血管生成抑制活性和癌转移抑制活性。 [R 1表示3〜10元非芳香族杂环基等， R2和R3表示氢; R 4，R 5，R 6和R 7可以相同或不同，各自表示氢，卤素，C 1-6烷基等; R8表示氢等; R9表示3〜10元非芳香族杂环基等， n表示1或2的整数; X表示-CH =，氮等。]

    Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
    10.
    发明授权
    Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same 有权
    被杂芳基环取代的吡啶衍生物，及含有它们的抗真菌剂

    公开(公告)号：US08183264B2

    公开(公告)日：2012-05-22

    申请号：US12442293

    申请日：2007-09-20

    申请人： Masayuki Matsukura ,  Satoshi Inoue ,  Keigo Tanaka ,  Norio Murai ,  Shuji Shirotori

    发明人： Masayuki Matsukura ,  Satoshi Inoue ,  Keigo Tanaka ,  Norio Murai ,  Shuji Shirotori

    IPC分类号： A61K31/4439 ,  C07D401/04

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04

    摘要： The present invention provides an antifungal agent that has excellent antifungal action, and is also excellent in terms of its properties, safety, and metabolic stability. The present invention discloses a compound represented by the following formula I or a salt thereof, and an antifungal agent comprising the compound or the salt: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6-alkoxy-C1-6-alkyl group; R2 represents a hydrogen atom or an amino group; X, Y, Z, and W independently represent a nitrogen atom, an oxygen atom, a sulfur atom, or —CH—, provided that at least two among X, Y, and W are nitrogen atoms; the ring A represents a 5- or 6-membered heteroaryl ring or a benzene ring; Q represents a methylene group, an oxygen atom, —CH2O—, —OCH2—, —NH—, —NHCH2—, or —CH2NH—; and R3 represents a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, or a 5- or 6-membered heteroaryl group, each of which may have one or two substituents.

    摘要翻译： 本发明提供具有优异抗真菌作用的抗真菌剂，并且在其性质，安全性和代谢稳定性方面也是优异的。 本发明公开了由下式I表示的化合物或其盐，以及包含该化合物或其盐的抗真菌剂：其中R1表示氢原子，卤素原子，氨基，C1-6烷基， C 1-6烷氧基或C 1-6 - 烷氧基-C 1-6 - 烷基; R2表示氢原子或氨基; X，Y，Z和W独立地表示氮原子，氧原子，硫原子或-CH-，条件是X，Y和W中的至少两个是氮原子; 环A表示5-或6-元杂芳基环或苯环; Q表示亚甲基，氧原子，-CH 2 O - ， - OCH 2 - ， - NH - ， - NHCH 2 - 或-CH 2 NH-; 并且R 3表示可以具有一个或两个取代基的C 1-6烷基，C 3-8环烷基，C 6-10芳基或5或6元杂芳基。