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1.发明授权Phenoxypyridine derivative salts and crystals thereof, and process for preparing the same 有权苯氧基吡啶衍生物盐及其晶体及其制备方法公开(公告)号：US08377938B2
公开(公告)日：2013-02-19
申请号：US12031568
申请日：2008-02-14
申请人： Tomohiro Matsushima , Shuji Shirotori , Keiko Takahashi , Atsushi Kamada , Kazunori Wakasugi , Takahisa Sakaguchi
发明人： Tomohiro Matsushima , Shuji Shirotori , Keiko Takahashi , Atsushi Kamada , Kazunori Wakasugi , Takahisa Sakaguchi
IPC分类号： A61K31/496 , A61K31/4427 , C07D401/12
CPC分类号： C07D401/12 , C07D213/75 , C07D239/47 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention provides acid addition salts of the compounds represented by formula (1) or (2), or crystals thereof, and processes for preparing the same. The salts or crystals have HGFR inhibitory activity and excellent physical properties (solubility, safety, etc.) and are therefore useful as anti-tumor agents, angiogenesis inhibitors and inhibitors for metastasis for a various types of tumor.
摘要翻译： 本发明提供式（1）或（2）表示的化合物或其结晶的酸加成盐及其制备方法。 盐或晶体具有HGFR抑制活性和优异的物理性质（溶解性，安全性等），因此可用作各种肿瘤的抗肿瘤剂，血管发生抑制剂和转移抑制剂。
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2.发明申请公开(公告)号：US20080318924A1
公开(公告)日：2008-12-25
申请号：US12031568
申请日：2008-02-14
申请人： Tomohiro MATSUSHIMA , Shuji Shirotori , Keiko Takahashi , Atsushi Kamada , Kazunori Wakasugi , Takahisa Sakaguchi
发明人： Tomohiro MATSUSHIMA , Shuji Shirotori , Keiko Takahashi , Atsushi Kamada , Kazunori Wakasugi , Takahisa Sakaguchi
IPC分类号： A61K31/4427 , C07D401/14 , C07D401/12 , A61P35/00 , A61K31/496
CPC分类号： C07D401/12 , C07D213/75 , C07D239/47 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention provides acid addition salts of the compounds represented by formula (1) or (2), or crystals thereof, and processes for preparing the same. The salts or crystals have HGFR inhibitory activity and excellent physical properties (solubility, safety, etc.) and are therefore useful as anti-tumor agents, angiogenesis inhibitors and inhibitors for metastasis for a various types of tumor.
摘要翻译： 本发明提供式（1）或（2）表示的化合物或其结晶的酸加成盐及其制备方法。 盐或晶体具有HGFR抑制活性和优异的物理性质（溶解性，安全性等），因此可用作各种肿瘤的抗肿瘤剂，血管发生抑制剂和转移抑制剂。
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公开(公告)号：US07790885B2
公开(公告)日：2010-09-07
申请号：US11892785
申请日：2007-08-27
申请人： Mitsuo Nagai , Tomohiro Matsushima , Atsushi Kamada , Kazunori Wakasugi , Shuji Shirotori , Shinya Abe , Kazumasa Nara , Takahisa Sakaguchi
发明人： Mitsuo Nagai , Tomohiro Matsushima , Atsushi Kamada , Kazunori Wakasugi , Shuji Shirotori , Shinya Abe , Kazumasa Nara , Takahisa Sakaguchi
IPC分类号： C07D239/02 , C07D213/00 , C07D213/81
CPC分类号： C07D213/73 , C07D213/75 , C07D213/81 , C07D401/12
摘要： A process for preparing a compound represented by the formula (I): comprising reacting a compound represented by the formula (II) or salt thereof: with a compound represented by the formula (III): in the presence of a condensation reagent, wherein R1 represents 1) optionally substituted azetidin-1-yl, 2) optionally substituted pyrrolidin-1-yl, 3) optionally substituted piperidin-1-yl, etc.; R2, R3, R4 and R5 may be the same or different and each represents hydrogen or fluorine; and R6 represents hydrogen or fluorine.
摘要翻译： 一种制备由式（I）表示的化合物的方法：包括使由式（II）表示的化合物或其盐与式（III）表示的化合物反应：在缩合试剂存在下，其中R 1 表示1）任选取代的氮杂环丁烷-1-基，2）任选取代的吡咯烷-1-基，3）任选取代的哌啶-1-基等; R2，R3，R4和R5可以相同或不同，各自表示氢或氟; R6表示氢或氟。
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公开(公告)号：US20080214815A1
公开(公告)日：2008-09-04
申请号：US11892785
申请日：2007-08-27
申请人： Mitsuo Nagai , Tomohiro Matsushima , Atsushi Kamada , Kazunori Wakasugi , Shuji Shirotori , Shinya Abe , Kazumasa Nara , Takahisa Sakaguchi
发明人： Mitsuo Nagai , Tomohiro Matsushima , Atsushi Kamada , Kazunori Wakasugi , Shuji Shirotori , Shinya Abe , Kazumasa Nara , Takahisa Sakaguchi
IPC分类号： C07D401/12
CPC分类号： C07D213/73 , C07D213/75 , C07D213/81 , C07D401/12
摘要： A process for preparing a compound represented by the formula (I): comprising reacting a compound represented by the formula (II) or salt thereof: with a compound represented by the formula (III): in the presence of a condensation reagent, wherein R1 represents 1) optionally substituted azetidin-1-yl, 2) optionally substituted pyrrolidin-1-yl, 3) optionally substituted piperidin-1-yl, etc.; R2, R3, R4 and R5 may be the same or different and each represents hydrogen or fluorine; and R6 represents hydrogen or fluorine.
摘要翻译： 一种制备由式（I）表示的化合物的方法：包括使由式（II）表示的化合物或其盐与式（III）表示的化合物反应：在缩合试剂存在下，其中R 代表1）任选取代的氮杂环丁烷-1-基，2）任选取代的吡咯烷-1-基，3）任选取代的哌啶-1-基等; R 2，R 3，R 4和R 5可以相同或不同，各自代表氢或 氟; R 6表示氢或氟。
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5.发明授权Crystalline form of the salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide or the solvate of the salt and a process for preparing the same 有权4-（3-氯-4-（环丙基氨基羰基）氨基苯氧基）-7-甲氧基-6-喹啉甲酰胺或盐的溶剂化物的盐的结晶形式及其制备方法公开(公告)号：US07612208B2
公开(公告)日：2009-11-03
申请号：US10577531
申请日：2004-12-22
申请人： Tomohiro Matsushima , Taiju Nakamura , Kazuhiro Yoshizawa , Atsushi Kamada , Yusuke Ayata , Naoko Suzuki , Itaru Arimoto , Takahisa Sakaguchi , Masaharu Gotoda
发明人： Tomohiro Matsushima , Taiju Nakamura , Kazuhiro Yoshizawa , Atsushi Kamada , Yusuke Ayata , Naoko Suzuki , Itaru Arimoto , Takahisa Sakaguchi , Masaharu Gotoda
IPC分类号： C07D215/38
CPC分类号： C07D215/48
摘要： A crystal of a 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide hydrochloride, hydrobromide, p-toluenesulfonate, sulfate, methanesulfonate or ethanesulfonate, or a solvate thereof.
摘要翻译： 4-（3-氯-4-（环丙基氨基羰基）氨基苯氧基）-7-甲氧基-6-喹啉甲酰胺盐酸盐，氢溴酸盐，对甲苯磺酸盐，硫酸盐，甲磺酸盐或乙磺酸盐或其溶剂化物的晶体。
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6.发明申请Amorphous salt of 4-(3-chiloro-4-(cycloproplylaminocarbonyl)aminophenoxy)-7-method-6-quinolinecarboxamide and process for preparing the same 有权4-（3-氯-4-（环丙基氨基羰基）氨基苯氧基）-7-方法-6-喹啉甲酰胺的无定形盐及其制备方法公开(公告)号：US20070004773A1
公开(公告)日：2007-01-04
申请号：US11472372
申请日：2006-06-22
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： C07D215/48
摘要： An amorphous form of a salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide.
摘要翻译： 4-（3-氯-4-（环丙基氨基羰基）氨基苯氧基）-7-甲氧基-6-喹啉甲酰胺的盐的无定形形式。
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7.发明申请Crystal of Indole Derivative Having Piperidine Ring and Process for Production Thereof 审中-公开具有哌啶环的吲哚衍生物的晶体及其制备方法公开(公告)号：US20080227815A1
公开(公告)日：2008-09-18
申请号：US11913931
申请日：2006-05-11
申请人： Takahisa Sakaguchi , Yuichi Suzuki , Koichi Ito , Jun Niijima , Mamoru Miyazawa , Toshikazu Shimizu , Masaharu Gotoda , Naoko Suzuki , Takashi Hasebe
发明人： Takahisa Sakaguchi , Yuichi Suzuki , Koichi Ito , Jun Niijima , Mamoru Miyazawa , Toshikazu Shimizu , Masaharu Gotoda , Naoko Suzuki , Takashi Hasebe
IPC分类号： A61K31/454 , C07D405/14 , A61P25/18 , A61P25/30
CPC分类号： C07D405/14
摘要： A crystal of 1-[1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)-ethyl]piperidin-4-yl]-N-methyl-1H-indole-6-carboxamide fumarate which has peaks at chemical shifts of about 124.0 ppm and about 26.8 ppm in a 13C solid NMR spectrum.
摘要翻译： 1- [1- [2-（7-甲氧基-2,2-二甲基-4-氧代色满-8-基） - 乙基]哌啶-4-基] -N-甲基-1H-吲哚-6- 富马酸甲酰胺，在13 C固体NMR光谱中具有约124.0ppm和约26.8ppm的化学位移的峰。
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8.发明授权Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and process for preparing the same 有权4-（3-氯-4-（环丙基氨基羰基）氨基苯氧基）-7-甲氧基-6-喹啉甲酰胺的无定形盐及其制备方法公开(公告)号：US07550483B2
公开(公告)日：2009-06-23
申请号：US11472372
申请日：2006-06-22
IPC分类号： A61K31/44 , C07D215/38
CPC分类号： C07D215/48
摘要： An amorphous form of a salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide.
摘要翻译： 4-（3-氯-4-（环丙基氨基羰基）氨基苯氧基）-7-甲氧基-6-喹啉甲酰胺的无定形形式。
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