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公开(公告)号：US20200215239A1
公开(公告)日：2020-07-09
申请号：US16319751
申请日：2017-07-28
发明人： Suguru Ushiro , Akihiro Hayashi , Yoshiyuki Ueno
摘要： A biological component adhesion-suppressing material includes a substrate provided with a functional layer having, fixed on a surface thereof that comes into contact with a biological component, a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit, wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device, the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.
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公开(公告)号：US20190255227A1
公开(公告)日：2019-08-22
申请号：US16333615
申请日：2017-09-20
发明人： Suguru Ushiro , Akihiro Hayashi , Yoshiyuki Ueno
摘要： A copolymer is capable of being immobilized on a base material while maintaining a high antithrombotic property persistently without having to introduce heparin or an anticoagulant drug to the surface thereof. The copolymer includes monomer unit A, monomer unit B, and monomer unit C, wherein monomer unit C has a mole fraction of 0.5-40% with respect to the total amount of all constituent monomer units.
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公开(公告)号：US10953142B2
公开(公告)日：2021-03-23
申请号：US16319751
申请日：2017-07-28
发明人： Suguru Ushiro , Akihiro Hayashi , Yoshiyuki Ueno
摘要： A biological component adhesion-suppressing material includes a substrate provided with a functional layer having, fixed on a surface thereof that comes into contact with a biological component, a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit, wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device, the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.
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公开(公告)号：US20190209744A1
公开(公告)日：2019-07-11
申请号：US16325429
申请日：2017-08-22
发明人： Suguru Ushiro , Akihiro Hayashi , Yoshiyuki Ueno
IPC分类号： A61L33/06
CPC分类号： A61L33/06 , A61M1/34 , A61M2205/7563 , B01D71/44
摘要： A medical material is capable of suppressing adhesion of platelets and proteins even when in contact with biological components such as blood for an extended period of time. The medical material is a copolymer including hydrophobic units and hydrophilic units in which the hydrophobic units have a C2-20 terminal alkyl group in a side chain, the static contact angle of water in the copolymer is at least 30° and less than 70°, and the glass transition temperature of the copolymer exists at only one point in the range from 45° C. to less than 90° C.
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公开(公告)号：US09993777B2
公开(公告)日：2018-06-12
申请号：US14913919
申请日：2014-09-26
发明人： Akihiro Hayashi , Shiro Nosaka , Yoshiyuki Ueno
CPC分类号： B01D67/0013 , A61M1/16 , B01D63/02 , B01D67/0016 , B01D69/02 , B01D69/08 , B01D71/58 , B01D71/68 , B01D2323/02 , B01D2325/02 , B01D2325/36
摘要： The purpose of the present invention is to provide a porous membrane that has both high water permeability and excellent protein fractionation performance. Provided is a method for producing a porous membrane, said method comprising a step for discharging a membrane-forming dope that contains a hydrophilic polymer from a slit formed in a mouthpiece, and a step for, after the passage of the discharged membrane-forming dope through a dry part, solidifying the membrane-forming dope in a coagulation bath to give a porous membrane, wherein the cross-section area of the slit is 3-30 times inclusive as large as the cross-section area of the solidified porous membrane.
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公开(公告)号：US20170072371A1
公开(公告)日：2017-03-16
申请号：US15308530
申请日：2015-05-07
发明人： Akihiro Hayashi , Yoshiyuki Ueno
CPC分类号： B01D71/68 , B01D63/02 , B01D63/021 , B01D65/02 , B01D69/02 , B01D69/08 , B01D71/38 , B01D71/40 , B01D71/44 , B01D71/52 , B01D2325/36
摘要： Disclosed is a hollow fiber membrane module including a case and a hollow fiber membrane built in the case, wherein the hollow fiber membrane contains a polysulfone-based polymer and a hydrophilic polymer, and satisfies the following (A) and (B), and an amount of an eluted substance contained in a liquid obtained by circulating ultrapure water heated at 37° C. through a passage of an inner surface side of the hollow fiber membrane for 4 hours at 200 mL/min is 1.0 mg/m2 or less: (A) an insoluble component accounts for less than 3% by mass of the total mass of the hollow fiber membrane when the hollow fiber membrane is dissolved in N,N-dimethylacetamide; and (B) a flexible layer exists on a surface of a functional layer in a wet state and the flexible layer has a thickness of 7 nm or more. The present invention provides a hollow fiber membrane module including a hollow fiber membrane containing a polysulfone-based polymer and a hydrophilic polymer built therein, which elutes little eluted substance and exhibits high biocompatibility, while change in performance due to crosslinking of the hydrophilic polymer is suppressed.
摘要翻译： 本发明公开了一种中空纤维膜组件，其包括外壳和中空纤维膜，其中所述中空纤维膜含有聚砜系聚合物和亲水性高分子，满足下述（A）和（B）， 将通过使中空纤维膜的内表面侧以200mL /分钟的通过4小时的方式将通过使在37℃下加热的超纯水循环而获得的液体的量为1.0mg / m 2以下：（ A）中空纤维膜溶解在N，N-二甲基乙酰胺中时，不溶成分占中空纤维膜总质量的3质量％以下; 和（B）在湿态的功能层的表面上存在柔性层，柔性层的厚度为7nm以上。 本发明提供一种中空纤维膜组件，其包含含有聚砜系聚合物和内置亲水性聚合物的中空纤维膜，其中洗脱少量洗脱物质并显示出高生物相容性，同时由于亲水性聚合物的交联而导致的性能变化被抑制 。
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公开(公告)号：US10912868B2
公开(公告)日：2021-02-09
申请号：US16325429
申请日：2017-08-22
发明人： Suguru Ushiro , Akihiro Hayashi , Yoshiyuki Ueno
摘要： A medical material is capable of suppressing adhesion of platelets and proteins even when in contact with biological components such as blood for an extended period of time. The medical material is a copolymer including hydrophobic units and hydrophilic units in which the hydrophobic units have a C2-20 terminal alkyl group in a side chain, the static contact angle of water in the copolymer is at least 30° and less than 70°, and the glass transition temperature of the copolymer exists at only one point in the range from 45° C. to less than 90° C.
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公开(公告)号：US20240173692A1
公开(公告)日：2024-05-30
申请号：US18283231
申请日：2022-03-17
CPC分类号： B01J20/262 , B01J20/28038 , B01J20/2808 , B01J2220/445
摘要： A porous adsorption material is used to adsorb and remove an impurity from a solution containing a raw biopharmaceutical compound while suppressing clogging and is high in separation selectivity. The porous adsorption material used to adsorb and remove an impurity from a solution containing a raw biopharmaceutical compound includes a layer containing a nonionic polymer on at least one surface of the porous adsorption material.
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公开(公告)号：US20210197141A1
公开(公告)日：2021-07-01
申请号：US16334597
申请日：2017-09-29
发明人： Suguru Ushiro , Akihiro Hayashi , Yoshiyuki Ueno
摘要： A separation membrane module includes a separation membrane including a hydrophobic polymer, a hydrophilic polymer, and polymer A, wherein the polymer A includes a hydrophilic unit and a hydrophobic unit, and is a copolymer having an alkyl group having 2 to 20 carbon atoms at a side-chain terminal of the hydrophobic unit, the separation membrane module having a retention rate of an albumin sieving coefficient of 86% or more at 60 minutes after circulation start relative to an albumin sieving coefficient at 10 minutes after circulation start when 2 L of bovine blood containing 50 U/ml of heparin, and having a hematocrit of 30% by volume and a total protein concentration of 6 to 7 g/dl is circulated at a flow rate of 100 ml/min at 37° C. and a filtration flow rate of 10 ml/(min·m2).
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公开(公告)号：US11000636B2
公开(公告)日：2021-05-11
申请号：US16333615
申请日：2017-09-20
发明人： Suguru Ushiro , Akihiro Hayashi , Yoshiyuki Ueno
摘要： A copolymer is capable of being immobilized on a base material while maintaining a high antithrombotic property persistently without having to introduce heparin or an anticoagulant drug to the surface thereof. The copolymer includes monomer unit A, monomer unit B, and monomer unit C, wherein monomer unit C has a mole fraction of 0.5-40% with respect to the total amount of all constituent monomer units.
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