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    HOLLOW FIBER MEMBRANE MODULE AND MANUFACTURING METHOD THEREOF
    4.
    发明申请
    HOLLOW FIBER MEMBRANE MODULE AND MANUFACTURING METHOD THEREOF 审中-公开
    中空纤维膜模块及其制造方法

    公开(公告)号：US20170072371A1

    公开(公告)日：2017-03-16

    申请号：US15308530

    申请日：2015-05-07

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Akihiro Hayashi ,  Yoshiyuki Ueno

    IPC: B01D71/68 ,  B01D69/02 ,  B01D63/02 ,  B01D69/08 ,  B01D71/38

    CPC classification number: B01D71/68 ,  B01D63/02 ,  B01D63/021 ,  B01D65/02 ,  B01D69/02 ,  B01D69/08 ,  B01D71/38 ,  B01D71/40 ,  B01D71/44 ,  B01D71/52 ,  B01D2325/36

    Abstract: Disclosed is a hollow fiber membrane module including a case and a hollow fiber membrane built in the case, wherein the hollow fiber membrane contains a polysulfone-based polymer and a hydrophilic polymer, and satisfies the following (A) and (B), and an amount of an eluted substance contained in a liquid obtained by circulating ultrapure water heated at 37° C. through a passage of an inner surface side of the hollow fiber membrane for 4 hours at 200 mL/min is 1.0 mg/m2 or less: (A) an insoluble component accounts for less than 3% by mass of the total mass of the hollow fiber membrane when the hollow fiber membrane is dissolved in N,N-dimethylacetamide; and (B) a flexible layer exists on a surface of a functional layer in a wet state and the flexible layer has a thickness of 7 nm or more. The present invention provides a hollow fiber membrane module including a hollow fiber membrane containing a polysulfone-based polymer and a hydrophilic polymer built therein, which elutes little eluted substance and exhibits high biocompatibility, while change in performance due to crosslinking of the hydrophilic polymer is suppressed.

    Abstract translation: 本发明公开了一种中空纤维膜组件，其包括外壳和中空纤维膜，其中所述中空纤维膜含有聚砜系聚合物和亲水性高分子，满足下述（A）和（B）， 将通过使中空纤维膜的内表面侧以200mL /分钟的通过4小时的方式将通过使在37℃下加热的超纯水循环而获得的液体的量为1.0mg / m 2以下：（ A）中空纤维膜溶解在N，N-二甲基乙酰胺中时，不溶成分占中空纤维膜总质量的3质量％以下; 和（B）在湿态的功能层的表面上存在柔性层，柔性层的厚度为7nm以上。 本发明提供一种中空纤维膜组件，其包含含有聚砜系聚合物和内置亲水性聚合物的中空纤维膜，其中洗脱少量洗脱物质并显示出高生物相容性，同时由于亲水性聚合物的交联而导致的性能变化被抑制 。

    CELL ADSORPTION MATERIAL AND CELL ADSORPTION COLUMN
    6.
    发明申请
    CELL ADSORPTION MATERIAL AND CELL ADSORPTION COLUMN 有权

    公开(公告)号：US20250001399A1

    公开(公告)日：2025-01-02

    申请号：US18706366

    申请日：2022-10-26

    Applicant: Toray Industries, Inc.

    Inventor： Mariko Yamashita ,  Aishan Han ,  Hirokazu Sakaguchi ,  Yoshiyuki Ueno

    IPC: B01J20/289 ,  A61M1/36 ,  B01J20/26 ,  B01J20/28

    Abstract: A cell adsorption material includes fibers or particles of a water-insoluble carrier with at least one bound nitrogen-containing compound. The nitrogen-containing compound is selected from polyamines and aliphatic amines. The fibers or particles have a region A within 1.0 μm from an outermost surface of a cross-sectional surface of the fibers or the particles, and a region B within 0.5 μm radius from a center of gravity of the cross-sectional surface of the fibers or the particles, a spectral intensity of 26CN− satisfies formulae (1) and (2) when a spectral intensity of 25C2H− in each of the regions measured by Time of Flight Secondary Ion Mass Spectrometry is set to be 1:0.5≤the spectral intensity of 26CN− in the region A≤3.0 . . . (1); 3.0≤ the spectral intensity of 26CN− in the region A/the spectral intensity of 26CN− in the region B≤20.0 . . . (2).

    Medical material, medical separation membrane, and blood purifier
    7.
    发明授权
    Medical material, medical separation membrane, and blood purifier 有权

    公开(公告)号：US10912868B2

    公开(公告)日：2021-02-09

    申请号：US16325429

    申请日：2017-08-22

    Applicant: Toray Industries, Inc.

    Inventor： Suguru Ushiro ,  Akihiro Hayashi ,  Yoshiyuki Ueno

    IPC: A61L33/06 ,  A61M1/34 ,  B01D71/44

    Abstract: A medical material is capable of suppressing adhesion of platelets and proteins even when in contact with biological components such as blood for an extended period of time. The medical material is a copolymer including hydrophobic units and hydrophilic units in which the hydrophobic units have a C2-20 terminal alkyl group in a side chain, the static contact angle of water in the copolymer is at least 30° and less than 70°, and the glass transition temperature of the copolymer exists at only one point in the range from 45° C. to less than 90° C.

    POROUS FIBER, ADSORBENT MATERIAL, AND PURIFICATION COLUMN
    8.
    发明申请
    POROUS FIBER, ADSORBENT MATERIAL, AND PURIFICATION COLUMN 审中-公开

    公开(公告)号：US20190126239A1

    公开(公告)日：2019-05-02

    申请号：US16096530

    申请日：2017-04-20

    Applicant: Toray Industries, Inc.

    Inventor： Hiroaki Fujieda ,  Yoshiyuki Ueno ,  Kazumi Tanaka

    IPC: B01J20/26 ,  B01J20/28 ,  B01J20/285 ,  B01J20/30 ,  A61M1/16 ,  D01D5/253

    Abstract: A solid fiber has a modified cross-section which satisfies the following (a) to (b): (a) a modification degree Do/Di, in a cross section of the solid fiber, is 1.20 to 8.50 when the inscribed circle diameter is denoted by Di and the circumscribed circle diameter is denoted by Do; and (b) a porous specific surface area of the fiber is not less than 30 m2/g. An adsorbent material comprises not less than 28 vol % of the porous fiber as a fiber bundle. A purification column is formed by arranging the adsorbent material in the straight form in an axis direction of a plastic casing and by attaching an inlet port and an outlet port of a fluid that is to be treated to both ends of the plastic casing. The porous fiber can efficiently adsorb a removal target substance in the fluid that is to be treated, and a purification column incorporates the porous fiber.

    Blood purification column
    9.
    发明授权
    Blood purification column 有权

    公开(公告)号：US10213543B2

    公开(公告)日：2019-02-26

    申请号：US14765386

    申请日：2014-02-07

    Applicant: Toray Industries, Inc.

    Inventor： Hiroaki Fujieda ,  Yoshiyuki Ueno ,  Kazumi Tanaka

    IPC: A61M1/14 ,  A61M1/36 ,  B01J20/26 ,  B01J20/28 ,  A61M1/10

    Abstract: A blood purification column includes an adsorbent and a casing whose two ends are open ends, wherein the adsorbent is housed inside the casing, and wherein one of two casing ends is a blood inflow-side end portion and another is a blood outflow-side end portion, and wherein a filter is disposed at the blood inflow-side end portion and/or the blood outflow-side end portion of the casing, and wherein the filter satisfies (1)-(3): (1) an opening rate thereof is greater than or equal to 5% and less than or equal to 80%; (2) an equivalent diameter of an aperture thereof is greater than or equal to 1 μm and less than or equal to 5000 μm; (3) a ratio of the equivalent diameter of the aperture thereof to an average circle equivalent diameter of void spaces of the adsorbent is greater than or equal to 45%.

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