公开(公告)号：US20080069815A1

公开(公告)日：2008-03-20

申请号：US11836078

申请日：2007-08-08

申请人： Toshimitsu UEDE ,  Shigeyuki Kon ,  Yukihiko Saeki ,  Yasuyuki Yokosaki ,  Masaki Noda ,  Nobuchika Yamamoto

发明人： Toshimitsu UEDE ,  Shigeyuki Kon ,  Yukihiko Saeki ,  Yasuyuki Yokosaki ,  Masaki Noda ,  Nobuchika Yamamoto

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61P19/02

CPC分类号： C07K14/52 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/24 ,  C07K16/2842 ,  C07K16/2848 ,  C07K2317/34

摘要： An anti-osteopontin antibody which inhibits the binding of an integrin recognizing RGD sequence to osteopontin or its fragment, and which inhibits the binding of an integrin recognizing SVVYGLR sequence or sequence equivalent thereto to osteopontin or its fragment. This antibody is useful in remedies for autoimmune diseases, remedies for rheumatism and remedies for rheumatoid arthritis. Also, a method of treating autoimmune disease, rheumatism or rheumatoid arthritis is provided. This antibody is useful in diagnostics and a diagnostic method for rheumatism too.

摘要翻译： 一种抗骨桥蛋白抗体，其抑制识别RGD序列的整联蛋白与骨桥蛋白或其片段的结合，并且其抑制识别SVVYGLR序列或等同于其的序列的整联蛋白与骨桥蛋白或其片段的结合。 该抗体可用于自身免疫性疾病的治疗，风湿病的治疗和类风湿性关节炎的治疗。 此外，提供了治疗自身免疫性疾病，风湿病或类风湿性关节炎的方法。 该抗体也可用于诊断和风湿病的诊断方法。

公开(公告)号：US08658770B2

公开(公告)日：2014-02-25

申请号：US13503332

申请日：2010-10-19

申请人： Haruo Matsuda ,  Norihisa Nishimichi ,  Yoshiko Tateishi ,  Yasuyuki Yokosaki

发明人： Haruo Matsuda ,  Norihisa Nishimichi ,  Yoshiko Tateishi ,  Yasuyuki Yokosaki

IPC分类号： C07K16/00 ,  C07K16/46 ,  C07K16/28

CPC分类号： C07K16/2842 ,  G01N2333/7055

摘要： [Object] To obtain an anti-integrin α8β1 antibody which binds to integrin α8β1 derived from mammals of different species. Also, to obtain an anti-integrin α8β1 antibody which inhibits binding between integrin α8β1 and its ligand.[Solution] Anti-integrin α8β1 antibodies which bind to integrin α8β1 derived from mammals of different species have been obtained. In addition, inhibitors, which contain an anti-integrin α8β1 antibody, of binding between integrin α8β1 and its ligand have been obtained.

摘要翻译： [目的]获得结合来自不同物种的哺乳动物的整联蛋白α8beta1的抗整联蛋白α8beta1抗体。 此外，为了获得抑制整合素α8β1与其配体结合的抗整联蛋白α8beta1抗体。 [解决方案]已经获得了结合来自不同种类的哺乳动物的整合素α8beta1的抗整联蛋白α8beta1抗体。 此外，已经获得了含有整合素α8β1抗体的整合素α8β1与其配体结合的抑制剂。

公开(公告)号：US20120237530A1

公开(公告)日：2012-09-20

申请号：US13503332

申请日：2010-10-19

申请人： Haruo Matsuda ,  Norihisa Nishimichi ,  Yoshiko Tateishi ,  Yasuyuki Yokosaki

发明人： Haruo Matsuda ,  Norihisa Nishimichi ,  Yoshiko Tateishi ,  Yasuyuki Yokosaki

IPC分类号： A61K39/395 ,  C12N15/13 ,  C07K16/28

CPC分类号： C07K16/2842 ,  G01N2333/7055

摘要： [Object] To obtain an anti-integrin α8β1 antibody which binds to integrin α8β1 derived from mammals of different species. Also, to obtain an anti-integrin α8β1 antibody which inhibits binding between integrin α8β1 and its ligand.[Solution] Anti-integrin α8β1 antibodies which bind to integrin α8β1 derived from mammals of different species have been obtained. In addition, inhibitors, which contain an anti-integrin α8β1 antibody, of binding between integrin α8β1 and its ligand have been obtained.

摘要翻译： [目的]获得与来自不同种类哺乳动物的整联蛋白α8和bgr1结合的抗整联蛋白α8和bgr1抗体。 此外，为了获得抑制整合素α8和bgr1与其配体结合的抗整联蛋白α8＆bgr1抗体。 [解决方案]已经获得了结合来自不同种类的哺乳动物的整联蛋白α8和bgr1的抗整联蛋白α8和bgr1抗体。 此外，已经获得了含有整联蛋白α8和bgr1抗体的整联蛋白α8和bgr1与其配体结合的抑制剂。