公开(公告)号：US20110065667A1

公开(公告)日：2011-03-17

申请号：US12951964

申请日：2010-11-22

申请人： Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： A61K31/695 ,  C07D231/10 ,  C07D413/12 ,  C07D281/06 ,  C07F7/10 ,  A61K31/415 ,  A61K31/5377 ,  A61K31/553 ,  A61P25/28 ,  A61P25/18 ,  A61P3/10 ,  A61P25/24 ,  A61P25/08 ,  A61P25/00

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

公开(公告)号：US08183387B2

公开(公告)日：2012-05-22

申请号：US12951964

申请日：2010-11-22

申请人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： C07D231/10

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的苯基吡唑衍生物或其药学上可接受的盐：其中可以相同或不同的R 1和R 2各自表示C 1 -C 6烷基或C 3 -C 8环烷基，或者R 1和R 2各自连接 与其相邻的氮原子一起形成4-至7-元饱和杂环（其中所述饱和杂环可被卤素或C 1 -C 6烷基取代），n表示0至2的整数，T表示氢 原子，卤素或C 1 -C 6烷基，R表示式（I）：等）。

公开(公告)号：US20100267687A1

公开(公告)日：2010-10-21

申请号：US12741754

申请日：2008-11-13

申请人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： A61K31/4155 ,  C07D403/12 ,  A61P25/28 ,  A61P25/18 ,  A61P25/08 ,  A61P3/04 ,  A61P3/10 ,  A61P3/06 ,  C07D413/14 ,  A61K31/5377 ,  C07D231/14 ,  C07D401/14 ,  A61K31/4439 ,  A61K31/422 ,  A61K31/454 ,  A61K31/553 ,  C07D403/14 ,  A61K31/496

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的苯基吡唑衍生物或其药学上可接受的盐：其中可以相同或不同的R 1和R 2各自表示C 1 -C 6烷基或C 3 -C 8环烷基，或者R 1和R 2各自连接 与其相邻的氮原子一起形成4-至7-元饱和杂环（其中所述饱和杂环可被卤素或C 1 -C 6烷基取代），n表示0至2的整数，T表示氢 原子，卤素或C 1 -C 6烷基，R表示式（I）：等）。

公开(公告)号：US08193176B2

公开(公告)日：2012-06-05

申请号：US12951978

申请日：2010-11-22

申请人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： A61K31/5377 ,  A61K31/4155 ,  A61K31/397 ,  A61K31/553 ,  A61K31/496

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

公开(公告)号：US20110065668A1

公开(公告)日：2011-03-17

申请号：US12951978

申请日：2010-11-22

申请人： Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： A61K31/695 ,  A61K31/415 ,  A61K31/5377 ,  A61K31/553 ,  A61P25/28 ,  A61P25/18 ,  A61P3/10 ,  A61P25/24 ,  A61P25/08 ,  A61P25/00

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的苯基吡唑衍生物或其药学上可接受的盐：其中可以相同或不同的R 1和R 2各自表示C 1 -C 6烷基或C 3 -C 8环烷基，或者R 1和R 2各自连接 与其相邻的氮原子一起形成4-至7-元饱和杂环（其中所述饱和杂环可被卤素或C 1 -C 6烷基取代），n表示0至2的整数，T表示氢 原子，卤素或C 1 -C 6烷基，R表示式（I）：等）。

公开(公告)号：US07888354B2

公开(公告)日：2011-02-15

申请号：US12741754

申请日：2008-11-13

申请人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： A61K31/5377 ,  A61K31/397 ,  A61K31/495 ,  A61K31/4155 ,  C07D413/14 ,  C07D403/14 ,  C07D205/02 ,  C07D231/10

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的苯基吡唑衍生物或其药学上可接受的盐：其中可以相同或不同的R 1和R 2各自表示C 1 -C 6烷基或C 3 -C 8环烷基，或者R 1和R 2各自连接 与其相邻的氮原子一起形成4-至7-元饱和杂环（其中所述饱和杂环可被卤素或C 1 -C 6烷基取代），n表示0至2的整数，T表示氢 原子，卤素或C 1 -C 6烷基，R表示式（I）：等）。

公开(公告)号：US20140081025A1

公开(公告)日：2014-03-20

申请号：US14115933

申请日：2012-05-08

申请人： Ryo Suzuki ,  Aya Futamura ,  Masahito Abe ,  Shuhei Kashiwa ,  Nobutaka Hattori ,  Dai Nozawa ,  Hiroshi Ohta ,  Yuko Araki

发明人： Ryo Suzuki ,  Aya Futamura ,  Masahito Abe ,  Shuhei Kashiwa ,  Nobutaka Hattori ,  Dai Nozawa ,  Hiroshi Ohta ,  Yuko Araki

IPC分类号： C07D413/14 ,  C07D413/12 ,  C07D401/14

CPC分类号： C07D413/14 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12

摘要： The compound represented by formula (IA) or a pharmaceutically acceptable salt thereof is based on orexin (OX) receptor antagonist activity, is useful in the treatment and prevention of illnesses including sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependency, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, pain, gastrointestinal disease, epilepsy, inflammation, immunological disease, endocrinological related disease, and hypertension.

摘要翻译： 由式（IA）表示的化合物或其药学上可接受的盐是基于食欲肽（OX）受体拮抗剂活性，可用于治疗和预防包括睡眠障碍，抑郁症，焦虑障碍，恐慌症，精神分裂症，药物依赖性 ，阿尔茨海默病，帕金森病，亨廷顿舞蹈病，进食障碍，疼痛，胃肠道疾病，癫痫，炎症，免疫疾病，内分泌相关疾病和高血压。

公开(公告)号：US20100081825A1

公开(公告)日：2010-04-01

申请号：US12444275

申请日：2007-10-05

申请人： Yoshinori Sekiguchi ,  Kosuke Kanuma ,  Kazunari Sakagami ,  Masato Hayashi ,  Shuhei Kashiwa ,  Katsunori Omodera

发明人： Yoshinori Sekiguchi ,  Kosuke Kanuma ,  Kazunari Sakagami ,  Masato Hayashi ,  Shuhei Kashiwa ,  Katsunori Omodera

IPC分类号： C07D211/58 ,  C07D401/10

CPC分类号： C07D405/12 ,  C07D211/58 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D409/12

摘要： Disclosed is a pharmaceutical composition comprising a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient, which has an antagonistic activity on a melanin-concentrating hormone receptor. The pharmaceutical composition is useful, due to its antagonistic activity on a MCH receptor, for the prevention or treatment of a disease such as depression, anxiety disorders (e.g., generalized anxiety disorder, post traumatic stress disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder), attention deficit disorder, mania, manic-depressive disorder, schizophrenia, mood disorders, stress, sleep disorder, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, a cardiovascular diseases, hypertension, dyslipidemia, cardiac infarction, movement disorder (e.g., Parkinson's disease, epilepsy, convulsion, tremor), drug abuse and drug addiction.

摘要翻译： 公开了一种药物组合物，其包含式（I）表示的化合物或其药学上可接受的盐作为活性成分，其对黑色素浓缩激素受体具有拮抗作用。 由于其对MCH受体的拮抗活性，药物组合物可用于预防或治疗诸如抑郁症，焦虑症（例如广泛性焦虑症，创伤后应激障碍，恐慌症，强迫症， 社会焦虑障碍），注意力缺陷障碍，躁狂症，躁狂抑郁障碍，精神分裂症，情绪障碍，压力，睡眠障碍，发作，记忆障碍，认知障碍，痴呆，遗忘症，del妄，肥胖，进食障碍，食欲障碍， 糖尿病，心血管疾病，高血压，血脂异常，心肌梗死，运动障碍（如帕金森病，癫痫，惊厥，震颤），药物滥用和药物成瘾。

公开(公告)号：US20100238517A1

公开(公告)日：2010-09-23

申请号：US12725776

申请日：2010-03-17

申请人： Shuhei Kashiwa

发明人： Shuhei Kashiwa

IPC分类号： H04N1/387 ,  H04N1/40

CPC分类号： H04N1/00469 ,  G03G15/502 ,  H04N1/00411 ,  H04N1/0044 ,  H04N1/00458 ,  H04N2201/0094

摘要： An image processing device includes an image reading part for reading an image of a document and generating image data, a preview image creation part for creating preview image from the image data generated by the image reading part, a display part capable of displaying at least one part of the preview image, an operation input part for receiving input in response to operation made by a user, a display area determination part for determining a part specified in response to operation made through the operation input part as a displaying area of the preview image, and a display control part for extracting an image responsive to the displaying area from the preview image and for displaying the extracted image on the display part. So, a load for user's operation for preview of an image read from a document may be reduced, and page update and others may be executed efficiently by reducing time to preview display.

摘要翻译： 图像处理装置包括用于读取文档的图像并生成图像数据的图像读取部件，用于从由图像读取部件生成的图像数据创建预览图像的预览图像生成部件，能够显示至少一个 预览图像的一部分，用于响应于由用户进行的操作而接收输入的操作输入部分，用于确定响应于通过操作输入部分进行的操作而指定的部分作为预览图像的显示区域的显示区域确定部分 以及显示控制部分，用于响应于来自预览图像的显示区域提取图像，并用于在显示部分上显示提取的图像。 因此，可以减少用于用于预览从文档读取的图像的用于操作的负载，并且可以通过减少预览显示的时间来有效地执行页面更新等。

公开(公告)号：US08947754B2

公开(公告)日：2015-02-03

申请号：US12725776

申请日：2010-03-17

申请人： Shuhei Kashiwa

发明人： Shuhei Kashiwa

IPC分类号： G06K15/00 ,  G03F3/08 ,  H04N1/46 ,  H04N5/222 ,  H04N1/00 ,  G03G15/00

CPC分类号： H04N1/00469 ,  G03G15/502 ,  H04N1/00411 ,  H04N1/0044 ,  H04N1/00458 ,  H04N2201/0094

摘要： An image processing device includes an image reading part for reading an image of a document and generating image data, a preview image creation part for creating preview image from the image data generated by the image reading part, a display part capable of displaying at least one part of the preview image, an operation input part for receiving input in response to operation made by a user, a display area determination part for determining a part specified in response to operation made through the operation input part as a displaying area of the preview image, and a display control part for extracting an image responsive to the displaying area from the preview image and for displaying the extracted image on the display part. So, a load for user's operation for preview of an image read from a document may be reduced, and page update and others may be executed efficiently by reducing time to preview display.

摘要翻译： 图像处理装置包括用于读取文档的图像并生成图像数据的图像读取部件，用于从由图像读取部件生成的图像数据创建预览图像的预览图像生成部件，能够显示至少一个 预览图像的一部分，用于响应于由用户进行的操作而接收输入的操作输入部分，用于确定响应于通过操作输入部分进行的操作而指定的部分作为预览图像的显示区域的显示区域确定部分 以及显示控制部分，用于响应于来自预览图像的显示区域提取图像，并用于在显示部分上显示提取的图像。 因此，可以减少用于用于预览从文档读取的图像的用于操作的负载，并且可以通过减少预览显示的时间来有效地执行页面更新等。