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1.发明授权
公开(公告)号：US4898890A
公开(公告)日：1990-02-06
申请号：US157509
申请日：1987-12-23
申请人： Toshio Sato , Hitoshi Matsumoto , Hisao Kakegawa
发明人： Toshio Sato , Hitoshi Matsumoto , Hisao Kakegawa
IPC分类号： A61K31/12
CPC分类号： A61K31/12 , Y10S514/885
摘要： A novel medicine containing isoliquiritigenin as the active ingredient is disclosed, which exhibits excellent effects when used as a medicine for the therapy and prevention of kidney diseases, a medicine for the therapy and prevention of liver diseases, and a medicine for the therapy and prevention of complication resulting from diseases of these organs.
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公开(公告)号：US5143648A
公开(公告)日：1992-09-01
申请号：US748176
申请日：1991-08-20
IPC分类号： C07D307/62 , C07D405/12 , C07D405/14 , C07D407/04
CPC分类号： C07D405/12 , C07D307/62 , C07D405/14 , C07D407/04
摘要： This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.
摘要翻译： 本发明涉及一种具有优异抗氧化作用的新型抗坏血酸衍生物及其制备方法。 此外，本发明还涉及包含上述抗坏血酸衍生物或其它已知抗坏血酸衍生物的新型抗氧化剂。
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公开(公告)号：US5194445A
公开(公告)日：1993-03-16
申请号：US700176
申请日：1991-05-20
IPC分类号： C07D307/62
CPC分类号： C07D307/62
摘要： The preparation for preventing and curing organ dysfunctions, provided by the present invention, is a medicament having the activity to prevent and cure organ dysfunctions which active oxygen species and active organic radical species would cause, and unconventionally improved in stability in vivo by containing, as an active component, the ascorbic acid derivative of the formula, ##STR1## wherein R.sub.2 is a group selected from the class consisting of an alkylcarbonyl lower alkyl group of which the terminal alkyl group has 7 inclusive to 15 inclusive carbon atoms, an alkyl group having 9 inclusive to 17 inclusive alkyl groups and an alkoxycarbonyl lower alkyl group of which the terminal alkoxy group has 7 inclusive to 20 inclusive carbon atoms; and the ascorbic acid derivative of the above formula in which R.sub.2 is an alkylcarbonyl lower alkyl group of which the terminal alkyl group has 7 inclusive to 15 inclusive carbon atoms is novel and disclosed in the present specification together with the process for its preparation.
摘要翻译： PCT No.PCT / JP90 / 01157 Sec。 371日期1991年5月20日 102（e）日期1991年5月20日PCT提交1990年9月11日PCT公布。 公开号WO90 / 03471 1991年3月21日。本发明提供的预防和治疗器官功能障碍的制剂是具有预防和治疗活性氧物质和活性有机自由基物质将引起的器官功能障碍的活性的药物，并且非常规地改善 通过含有作为活性组分的下式的抗坏血酸衍生物，其中R2是选自末端烷基的烷基羰基低级烷基（包括末端烷基）为7以上的基团 碳原子数为9〜20的烷基，末端烷氧基为碳原子数为7〜20的烷氧基羰基低级烷基， 和上述式的抗坏血酸衍生物，其中R2是末端烷基具有7个包括15个碳原子的烷基羰基低级烷基，在本说明书中与其制备方法一起是新的和公开的。
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公开(公告)号：US4732916A
公开(公告)日：1988-03-22
申请号：US886158
申请日：1986-07-16
申请人： Toshio Satoh , Hitoshi Matsumoto , Hisao Kakegawa
发明人： Toshio Satoh , Hitoshi Matsumoto , Hisao Kakegawa
IPC分类号： A61K31/165 , A61P1/04 , C07C67/00 , C07C239/00 , C07C279/14 , C07C129/08 , A61K31/65 , C07C103/28
CPC分类号： C07C279/14
摘要： A guanidinomethylbenzoic acid derivative represented by the formula ##STR1## or a salt thereof. An antiulcer agent comprising the compounds of the afore-said formula as an effective ingredient is also disclosed.
摘要翻译： 由式“IMAGE”表示的胍基甲基苯甲酸衍生物或其盐。 还公开了包含上述式的化合物作为有效成分的抗溃疡剂。
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公开(公告)号：US5004742A
公开(公告)日：1991-04-02
申请号：US392899
申请日：1989-08-14
IPC分类号： C12N9/99 , A61K31/54 , A61P29/00 , A61P37/08 , A61P43/00 , C07D279/02 , C07D417/12
CPC分类号： C07D417/12 , C07D279/02
摘要： The present invention relates to novel benzothiazine-1,1-dioxide derivatives. These benzothiazine-1,1-dioxide derivatives have a high hyaluronidase-inhibiting activity and accordingly can be used in drugs such as anti-inflammatory agent, anti-allergic agent and the like.
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公开(公告)号：US5109025A
公开(公告)日：1992-04-28
申请号：US543845
申请日：1990-07-25
申请人： Toshio Satoh , Hitoshi Matsumoto , Hisao Kakegawa
发明人： Toshio Satoh , Hitoshi Matsumoto , Hisao Kakegawa
IPC分类号： A61K31/12
CPC分类号： A61K31/12
摘要： 2',3,4,4'-tetrahydroxychalcone and pharmacologically acceptable salts thereof are used as a therapeutic agent for treatment of renal disorders, and have activity for treatment of renal disorders and also for treatment of renal disorders accompanied by digestive disorders, and/or general inflammations, and/or allergic diseases.
摘要翻译： PCT No.PCT / JP89 / 01197 Sec。 371日期1990年7月25日第 102（e）日期1990年7月25日PCT 1989年11月24日PCT公布。 出版物WO90 / 06108 日期：1990年6月14日，3,4,4'-四羟基查耳酮及其药理学上可接受的盐被用作治疗肾脏疾病的治疗剂，并且具有治疗肾脏疾病的活性，还用于治疗伴随着 消化系统疾病和/或一般炎症和/或过敏性疾病。
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公开(公告)号：US5061812A
公开(公告)日：1991-10-29
申请号：US382270
申请日：1989-07-20
IPC分类号： C07D307/62 , C07D405/12 , C07D405/14 , C07D407/04
CPC分类号： C07D405/12 , C07D307/62 , C07D405/14 , C07D407/04
摘要： This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.
摘要翻译： 本发明涉及一种具有优异抗氧化作用的新型抗坏血酸衍生物及其制备方法。 此外，本发明还涉及包含上述抗坏血酸衍生物或其它已知抗坏血酸衍生物的新型抗氧化剂。
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公开(公告)号：US5034543A
公开(公告)日：1991-07-23
申请号：US382269
申请日：1989-07-20
IPC分类号： C07D405/14 , C07D407/04 , C09K15/06
CPC分类号： C07D405/14 , C07D407/04 , C09K15/06
摘要： This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the afore-mentioned novel ascorbic acid derivative or other known ascorbic acid derivatives.
摘要翻译： 本发明涉及具有优异抗氧化作用的抗坏血酸衍生物，特别是除去对超氧化物的作用及其制备方法。 此外，本发明还涉及包含上述新型抗坏血酸衍生物或其它已知抗坏血酸衍生物的新型抗氧化剂。
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公开(公告)号：US5264421A
公开(公告)日：1993-11-23
申请号：US852167
申请日：1992-04-06
CPC分类号： A61K36/48 , A23L33/105
摘要： A food composition prepared from a lactic acid fermented aqueous liquorice extract which is free of the disadvantages of extremely strong sweetness which makes liquorice extracts unsuitable for maintaining and enhancing the pharmacological activities (both disease preventing and treating effects) of treating ulcers and hepatic diseases.
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公开(公告)号：US5011949A
公开(公告)日：1991-04-30
申请号：US382771
申请日：1989-07-20
IPC分类号： C07D307/62 , C07D407/04 , G06F21/10 , H04N7/167 , H04N7/171
CPC分类号： C07D407/04 , C07D307/62
摘要： This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned novel ascorbic acid derivative or other known ascorbic acid derivatives.
摘要翻译： 本发明涉及具有优异抗氧化作用的抗坏血酸衍生物，特别是除去对超氧化物的作用及其制备方法。 此外，本发明还涉及包含上述新型抗坏血酸衍生物或其它已知抗坏血酸衍生物的新型抗氧化剂。
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