公开(公告)号：US11912693B2

公开(公告)日：2024-02-27

申请号：US16613152

申请日：2018-06-12

申请人： TREVENA, INC.

发明人： Philip Michael Pitis ,  Robert Eugene Boyd ,  Tamara Ann Miskowski Daubert ,  Michael John Hawkins ,  Guodong Liu ,  Aimee Crombie Speerschneider

IPC分类号： A61P25/02 ,  A61P35/00 ,  C07D413/14 ,  C07D413/04 ,  C07D405/14

CPC分类号： C07D413/04 ,  A61P25/02 ,  A61P35/00 ,  C07D405/14 ,  C07D413/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.

公开(公告)号：US20190202803A1

公开(公告)日：2019-07-04

申请号：US16286700

申请日：2019-02-27

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C.K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC分类号： C07D401/12 ,  C07D405/14 ,  C07D403/12 ,  C07D451/02 ,  A61K31/445 ,  C07D241/04 ,  C07D211/22 ,  C07D401/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US11465980B2

公开(公告)日：2022-10-11

申请号：US16286700

申请日：2019-02-27

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC分类号： C07D401/12 ,  A61K31/445 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D241/04 ,  C07D451/02 ,  C07D211/22

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US11225487B2

公开(公告)日：2022-01-18

申请号：US16486539

申请日：2018-02-15

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero

IPC分类号： C07D487/08 ,  A61P25/22 ,  A61P23/00 ,  A61P25/24 ,  C07D223/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US10246436B2

公开(公告)日：2019-04-02

申请号：US15252112

申请日：2016-08-30

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC分类号： A61K31/445 ,  C07D211/22 ,  C07D401/12 ,  C07D401/14 ,  C07D241/04 ,  C07D403/12 ,  C07D405/14 ,  C07D451/02

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US20230234946A1

公开(公告)日：2023-07-27

申请号：US18296018

申请日：2023-04-05

申请人： Trevena, Inc.

发明人： Philip Michael Pitis ,  Robert Eugene Boyd ,  Tamara Ann Miskowski Daubert ,  Michael John Hawkins ,  Guodong Liu ,  Aimee Crombie Speerschneider

IPC分类号： C07D413/04 ,  A61P25/02 ,  A61P35/00 ,  C07D413/14 ,  C07D405/14

CPC分类号： C07D413/04 ,  A61P25/02 ,  A61P35/00 ,  C07D413/14 ,  C07D405/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.

公开(公告)号：US20170210725A1

公开(公告)日：2017-07-27

申请号：US15252112

申请日：2016-08-30

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C.K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero ,  Gregory J. Pacofsky

IPC分类号： C07D401/12 ,  C07D451/02 ,  C07D405/14 ,  C07D401/14 ,  C07D211/22

CPC分类号： C07D401/12 ,  A61K31/445 ,  C07D211/22 ,  C07D241/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D451/02 ,  A61K2300/00

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US11912713B2

公开(公告)日：2024-02-27

申请号：US17532413

申请日：2021-11-22

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero

IPC分类号： C07D487/08 ,  A61P25/22 ,  A61P23/00 ,  A61P25/24 ,  C07D223/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

CPC分类号： C07D487/08 ,  A61P23/00 ,  A61P25/22 ,  A61P25/24 ,  C07D223/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US20230303531A1

公开(公告)日：2023-09-28

申请号：US18314913

申请日：2023-05-10

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C.K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero

IPC分类号： C07D403/12 ,  A61P25/22 ,  A61P25/24 ,  A61P29/00 ,  A61P25/06 ,  C07D403/14

CPC分类号： C07D403/12 ,  A61P25/22 ,  A61P25/24 ,  A61P29/00 ,  A61P25/06 ,  C07D403/14

摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

公开(公告)号：US11702408B2

公开(公告)日：2023-07-18

申请号：US16486541

申请日：2018-02-15

申请人： Trevena, Inc.

发明人： Aimee Crombie Speerschneider ,  Dennis Shinji Yamashita ,  Philip Michael Pitis ,  Michael John Hawkins ,  Guodong Liu ,  Tamara Ann Miskowski Daubert ,  Catherine C. K. Yuan ,  Robert Borbo Kargbo ,  Robert Jason Herr ,  Donna Romero

IPC分类号： C07D403/12 ,  C07D403/14 ,  A61P25/22 ,  A61P25/24 ,  A61P25/06 ,  A61P29/00

CPC分类号： C07D403/12 ,  A61P25/06 ,  A61P25/22 ,  A61P25/24 ,  A61P29/00 ,  C07D403/14

摘要： The present embodiments are directed, in part, to 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, such as those of Formula I, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinson's Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.