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1.
公开(公告)号:US20120035168A1
公开(公告)日:2012-02-09
申请号:US13194009
申请日:2011-07-29
申请人: Trixi BRANDL , Stefanie FLOHR , Sebastian KOPEC , Julie LACHAL , Christian MARKERT , Kenji NAMOTO , Perle NGANGA , Bernard PIRARD , Martin RENATUS , Richard SEDRANI , Thomas ZOLLER
发明人: Trixi BRANDL , Stefanie FLOHR , Sebastian KOPEC , Julie LACHAL , Christian MARKERT , Kenji NAMOTO , Perle NGANGA , Bernard PIRARD , Martin RENATUS , Richard SEDRANI , Thomas ZOLLER
IPC分类号: A61K31/4439 , C07D401/14 , A61K31/506 , A61K31/4709 , C07D409/14 , C07D495/04 , A61K31/4365 , C07D413/14 , C07D471/04 , A61K31/444 , A61K31/536 , A61P3/10 , A61P27/02 , A61P9/12 , A61P27/12 , A61P9/10 , A61P25/00 , A61P31/00 , A61P25/16 , A61P25/08 , C07D401/12
CPC分类号: C07D409/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/14
摘要: The invention relates to compound of the formula I in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
摘要翻译: 本发明涉及式I化合物,其中取代基如说明书中所定义; 以游离形式或盐形式; 作为其制备,用作药物和包含它的药物。
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公开(公告)号:US20170015637A1
公开(公告)日:2017-01-19
申请号:US15104729
申请日:2014-12-18
申请人: Birgit BOLLBUCK , Christian MARKERT , Wolfgang MILTZ , Till ROEHN
发明人: Birgit BOLLBUCK , Christian MARKERT , Wolfgang MILTZ , Till ROEHN
IPC分类号: C07D257/04 , A61K31/428 , C07D401/12 , A61K31/4439 , A61K31/415 , A61K31/422 , A61K31/41 , C07D271/10 , A61K31/4245 , C07D231/12 , C07D417/12 , C07D413/12
CPC分类号: C07D257/04 , A61K31/41 , A61K31/415 , A61K31/422 , A61K31/4245 , A61K31/428 , A61K31/4439 , A61K45/06 , C07D231/12 , C07D271/10 , C07D401/12 , C07D413/12 , C07D417/12
摘要: The present invention describes novel heteroaryl butanoic acid derivatives that are good drug candidates especially with regard to leukotriene A4 hydrolase (LTA4H). The present invention also relates to pharmaceutical compositions comprising said novel heteroaryl butanoic acid derivatives, methods of using said compounds in the treatment of various diseases and disorders, and processes for preparing the said novel compounds.
摘要翻译: 本发明描述了新颖的杂芳基丁酸衍生物,其是特别是关于白三烯A4水解酶(LTA4H)的良好药物候选物。 本发明还涉及包含所述新型杂芳基丁酸衍生物的药物组合物,使用所述化合物治疗各种疾病和病症的方法,以及制备所述新化合物的方法。
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