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公开(公告)号：US20170015637A1
公开(公告)日：2017-01-19
申请号：US15104729
申请日：2014-12-18
申请人： Birgit BOLLBUCK , Christian MARKERT , Wolfgang MILTZ , Till ROEHN
发明人： Birgit BOLLBUCK , Christian MARKERT , Wolfgang MILTZ , Till ROEHN
IPC分类号： C07D257/04 , A61K31/428 , C07D401/12 , A61K31/4439 , A61K31/415 , A61K31/422 , A61K31/41 , C07D271/10 , A61K31/4245 , C07D231/12 , C07D417/12 , C07D413/12
CPC分类号： C07D257/04 , A61K31/41 , A61K31/415 , A61K31/422 , A61K31/4245 , A61K31/428 , A61K31/4439 , A61K45/06 , C07D231/12 , C07D271/10 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention describes novel heteroaryl butanoic acid derivatives that are good drug candidates especially with regard to leukotriene A4 hydrolase (LTA4H). The present invention also relates to pharmaceutical compositions comprising said novel heteroaryl butanoic acid derivatives, methods of using said compounds in the treatment of various diseases and disorders, and processes for preparing the said novel compounds.
摘要翻译： 本发明描述了新颖的杂芳基丁酸衍生物，其是特别是关于白三烯A4水解酶（LTA4H）的良好药物候选物。 本发明还涉及包含所述新型杂芳基丁酸衍生物的药物组合物，使用所述化合物治疗各种疾病和病症的方法，以及制备所述新化合物的方法。
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公开(公告)号：US09981926B2
公开(公告)日：2018-05-29
申请号：US15104729
申请日：2014-12-18
申请人： Birgit Bollbuck , Christian Markert , Wolfgang Miltz , Till Roehn
发明人： Birgit Bollbuck , Christian Markert , Wolfgang Miltz , Till Roehn
IPC分类号： C07D257/04 , C07D401/00 , C07D403/00 , A61K31/41 , C07D231/12 , C07D401/12 , C07D413/12 , C07D417/12 , C07D271/10 , A61K45/06 , A61K31/415 , A61K31/422 , A61K31/4245 , A61K31/428 , A61K31/4439
CPC分类号： C07D257/04 , A61K31/41 , A61K31/415 , A61K31/422 , A61K31/4245 , A61K31/428 , A61K31/4439 , A61K45/06 , C07D231/12 , C07D271/10 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention describes novel heteroaryl butanoic acid derivatives that are good drug candidates especially with regard to leukotriene A4 hydrolase (LTA4H). The present invention also relates to pharmaceutical compositions comprising said novel heteroaryl butanoic acid derivatives, methods of using said compounds in the treatment of various diseases and disorders, and processes for preparing the said novel compounds.
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公开(公告)号：US08791100B2
公开(公告)日：2014-07-29
申请号：US13015919
申请日：2011-01-28
IPC分类号： A61K31/192 , A61K31/397 , A61K31/40 , A61K31/4439 , A61K31/4427 , C07D401/06 , C07D205/04 , C07D207/12 , C07C53/134
CPC分类号： C07D205/04 , C07C229/16 , C07D207/16 , C07D401/06
摘要： The present invention relates to substituted aryl-benzylamine compounds, to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及取代的芳基 - 苄胺化合物，其制备方法，用作药物和包含它们的药物组合物。
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公开(公告)号：US20110190258A1
公开(公告)日：2011-08-04
申请号：US13015919
申请日：2011-01-28
IPC分类号： A61K31/397 , C07D205/04 , C07D207/16 , A61K31/40 , C07C229/42 , A61K31/197 , C07D401/06 , A61K31/4427 , A61K31/4439 , A61P35/00 , A61P29/00 , A61P37/06 , A61P17/06 , A61P31/04 , A61P25/28 , A61P9/10 , A61P31/12 , A61P3/10 , A61P17/00
CPC分类号： C07D205/04 , C07C229/16 , C07D207/16 , C07D401/06
摘要： The present invention relates to substituted aryl-benzylamine compounds, to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及取代的芳基 - 苄胺化合物，其制备方法，其用作药物和包含它们的药物组合物。
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公开(公告)号：US20100029609A1
公开(公告)日：2010-02-04
申请号：US12440143
申请日：2007-09-06
IPC分类号： A61K31/397 , C07D207/00 , A61K31/40 , C07D265/30 , A61K31/535 , C07D205/04 , A61P25/00
CPC分类号： C07C311/21 , C07C311/29 , C07D205/04 , C07D207/16 , C07D213/30 , C07D213/76 , C07D231/18 , C07D233/84 , C07D241/04 , C07D241/24 , C07D257/04 , C07D277/36 , C07D307/79 , C07D307/82 , C07D333/34 , C07D333/62
摘要： A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof: wherein the groups R1-R5, R10 and X1-X7 are as defined in the specification.
摘要翻译： 式（I）化合物或其药学上可接受的盐或前药酯：其中R1-R5，R10和X1-X7基团如说明书中所定义。
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6.发明授权公开(公告)号：US07645760B2
公开(公告)日：2010-01-12
申请号：US10532331
申请日：2003-10-24
申请人： Birgit Bollbuck , Jorg Eder , Richard Heng , Laszio Revesz , Achim Schlapbach , Rudolf Walchli
发明人： Birgit Bollbuck , Jorg Eder , Richard Heng , Laszio Revesz , Achim Schlapbach , Rudolf Walchli
IPC分类号： C07D241/10 , C07D295/027 , A61K31/4965
CPC分类号： C07D295/185 , C07D207/14 , C07D207/16 , C07D207/28 , C07D211/48 , C07D211/58 , C07D215/38 , C07D233/74
摘要： A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases.
摘要翻译： 式（I）化合物或其药学上可接受的盐或酯，其中符号具有如上所定义的含义，其是CCR-1的拮抗剂，其可用于治疗CCR-1涉及的疾病和病症的药学上可用 ，例如 炎性疾病。
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公开(公告)号：US20100168079A1
公开(公告)日：2010-07-01
申请号：US12643517
申请日：2009-12-21
申请人： Daniela Angst , Birgit Bollbuck , Philipp Janser , Jean Quancard
发明人： Daniela Angst , Birgit Bollbuck , Philipp Janser , Jean Quancard
IPC分类号： A61K31/397 , C07C229/40 , A61K31/198 , C07D205/04 , C07C271/22 , A61K31/27 , A61P37/00 , A61P29/00 , A61P17/06 , A61P1/00 , A61P25/28
CPC分类号： C07D205/02 , C07C237/36 , C07C237/38 , C07C271/22 , C07C2601/02 , C07C2601/04
摘要： The present invention relates to biaryl-benzylamine compounds, to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及联芳基 - 苄胺化合物，其生产方法，其用作药物和包含它们的药物组合物。
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公开(公告)号：US07615562B2
公开(公告)日：2009-11-10
申请号：US10552317
申请日：2004-04-08
申请人： Birgit Bollbuck , Alastair DenholmMritain , Jörg Eder , René Hersperger , Philipp Janser , Lászlo Révész , Achim Schlapbach , Rudolf Wálchi
发明人： Birgit Bollbuck , Alastair DenholmMritain , Jörg Eder , René Hersperger , Philipp Janser , Lászlo Révész , Achim Schlapbach , Rudolf Wálchi
IPC分类号： C07D239/42 , C07D403/04 , A61K31/506
CPC分类号： C07D239/42 , C07D403/04 , C07D403/10 , C07D403/14 , C07D409/04 , C07D409/14 , C07D413/10
摘要： A compound of formula I or a pharmaceutically acceptable salt, ester or prodrug thereof wherein the variables have the meanings as defined in the specification. Further disclosed are a method of inhibiting IKK activity using a compound of formula I, a method of inhibiting production of TNF using a compound of formula I, a compound of formula I for use as a pharmaceutical, a pharmaceutical composition comprising a compound of formula I, and use of a compound of formula I in the manufacture of a medicament for use as an immunosuppressant or anti-inflammatory agent.
摘要翻译： 式I化合物或其药学上可接受的盐，酯或前药，其中变量具有说明书中定义的含义。 进一步公开的是使用式I化合物抑制IKK活性的方法，使用式I化合物抑制TNF产生的方法，用作药物的式I化合物，包含式I化合物的药物组合物 以及式I化合物在制备用作免疫抑制剂或抗炎剂的药物中的用途。
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公开(公告)号：US20070043048A1
公开(公告)日：2007-02-22
申请号：US10552317
申请日：2004-04-08
申请人： Birgit Bollbuck , Alastair DenholMritain , Laszlo Revesz , Achim Schlapbach , Rudolf Walchli , Jorg Eder , Rene Hersperger , Philipp Janser
发明人： Birgit Bollbuck , Alastair DenholMritain , Laszlo Revesz , Achim Schlapbach , Rudolf Walchli , Jorg Eder , Rene Hersperger , Philipp Janser
IPC分类号： A61K31/53 , A61K31/52 , A61K31/506 , C07D473/02 , C07D403/14
CPC分类号： C07D239/42 , C07D403/04 , C07D403/10 , C07D403/14 , C07D409/04 , C07D409/14 , C07D413/10
摘要： A compound of formula I or a pharmaceutically acceptable salt, ester or prodrug thereof wherein the variables have the meanings as defined in the specification. Further disclosed are a method of inhibiting IKK activity using a compound of formula I, a method of inhibiting production of TNF using a compound of formula I, a compound of formula I for use as a pharmaceutical, a pharmaceutical composition comprising a compound of formula I, and use of a compound of formula I in the manufacture of a medicament for use as an immunosuppressant or anti-inflammatory agent.
摘要翻译： 式I化合物或其药学上可接受的盐，酯或前药，其中变量具有说明书中定义的含义。 进一步公开的是使用式I化合物抑制IKK活性的方法，使用式I化合物抑制TNF产生的方法，用作药物的式I化合物，包含式I化合物的药物组合物 以及式I化合物在制备用作免疫抑制剂或抗炎剂的药物中的用途。
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10.发明申请公开(公告)号：US20060173004A1
公开(公告)日：2006-08-03
申请号：US10532331
申请日：2003-10-24
申请人： Birgit Bollbuck , Jorg Eder , Richard Heng , Laszlo Revesz , Achim Schlapbach , Rudolf Walchli
发明人： Birgit Bollbuck , Jorg Eder , Richard Heng , Laszlo Revesz , Achim Schlapbach , Rudolf Walchli
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , C07D413/02 , C07D403/02
CPC分类号： C07D295/185 , C07D207/14 , C07D207/16 , C07D207/28 , C07D211/48 , C07D211/58 , C07D215/38 , C07D233/74
摘要： A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases.
摘要翻译： 式（I）化合物或其药学上可接受的盐或酯，其中符号具有如上所定义的含义，其是CCR-1的拮抗剂，其可用于治疗CCR-1涉及的疾病和病症 ，例如 炎性疾病。
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