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1.
公开(公告)号:US20120035168A1
公开(公告)日:2012-02-09
申请号:US13194009
申请日:2011-07-29
申请人: Trixi BRANDL , Stefanie FLOHR , Sebastian KOPEC , Julie LACHAL , Christian MARKERT , Kenji NAMOTO , Perle NGANGA , Bernard PIRARD , Martin RENATUS , Richard SEDRANI , Thomas ZOLLER
发明人: Trixi BRANDL , Stefanie FLOHR , Sebastian KOPEC , Julie LACHAL , Christian MARKERT , Kenji NAMOTO , Perle NGANGA , Bernard PIRARD , Martin RENATUS , Richard SEDRANI , Thomas ZOLLER
IPC分类号: A61K31/4439 , C07D401/14 , A61K31/506 , A61K31/4709 , C07D409/14 , C07D495/04 , A61K31/4365 , C07D413/14 , C07D471/04 , A61K31/444 , A61K31/536 , A61P3/10 , A61P27/02 , A61P9/12 , A61P27/12 , A61P9/10 , A61P25/00 , A61P31/00 , A61P25/16 , A61P25/08 , C07D401/12
CPC分类号: C07D409/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/14
摘要: The invention relates to compound of the formula I in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.
摘要翻译: 本发明涉及式I化合物,其中取代基如说明书中所定义; 以游离形式或盐形式; 作为其制备,用作药物和包含它的药物。
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2.
公开(公告)号:US20140296217A1
公开(公告)日:2014-10-02
申请号:US14184821
申请日:2014-02-20
申请人: John Edward PARK , Gerald Juergen ROTH , Armin HECKEL , Nveed CHAUDHARY , Trixi BRANDL , Georg DAHMANN , Matthias GRAUERT
发明人: John Edward PARK , Gerald Juergen ROTH , Armin HECKEL , Nveed CHAUDHARY , Trixi BRANDL , Georg DAHMANN , Matthias GRAUERT
IPC分类号: C07D209/34 , C07D403/12 , A61K31/4045 , A61K31/454 , A61K31/5377 , A61K31/496 , A61K45/06 , A61K31/551 , C07D401/12 , A61K31/4178
CPC分类号: A61K31/4045 , A61K31/404 , A61K31/4178 , A61K31/44 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D209/34 , C07D295/155 , C07D295/215 , C07D401/12 , C07D403/12 , A61K2300/00
摘要: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.
摘要翻译: 本发明涉及在6位上被取代的通式的二氢吲哚酮的用途,其中R 1至R 5和X如权利要求1中所定义,其异构体及其盐,特别是其生理上可接受的盐作为药物用于 预防或治疗特定的纤维化疾病。
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3.Thiazolyl-dihydro-quinazoline compounds and processes for preparing same 失效
标题翻译: 噻唑基 - 二氢 - 喹唑啉化合物及其制备方法公开(公告)号:US20100145041A1
公开(公告)日:2010-06-10
申请号:US12706936
申请日:2010-02-17
申请人: Trixi BRANDL , Udo MAIER , Matthias HOFFMANN , Stefan SCHEUERER , Anne T. JOERGENSEN , Alexander PAUTSCH , Steffen BREITFELDER , Matthias GRAUERT , Christoph HOENKE , Klaus ERB , Michael PIEPER , Ingo PRAGST
发明人: Trixi BRANDL , Udo MAIER , Matthias HOFFMANN , Stefan SCHEUERER , Anne T. JOERGENSEN , Alexander PAUTSCH , Steffen BREITFELDER , Matthias GRAUERT , Christoph HOENKE , Klaus ERB , Michael PIEPER , Ingo PRAGST
IPC分类号: C07D417/14 , C07D413/14 , C07D513/04 , C07D277/82
CPC分类号: C07D513/04
摘要: Disclosed are thiazolyl-dihydro-quinazolines of general formula (I) wherein the groups R1 to R4 have the meanings given in the claims and specification, the isomers thereof, and processes for preparing these compounds and their use as pharmaceutical compositions.
摘要翻译: 公开了通式(I)的噻唑基 - 二氢 - 喹唑啉,其中基团R 1至R 4具有权利要求书和说明书中给出的含义,其异构体,以及这些化合物的制备方法及其作为药物组合物的用途。
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公开(公告)号:US20100113414A1
公开(公告)日:2010-05-06
申请号:US12685213
申请日:2010-01-11
申请人: Bodo BETZEMEIER , Trixi BRANDL , Steffen BREITFELDER , Ralph BRUECKNER , Thomas GERSTBERGER , Michael GMACHL , Matthias GRAUERT , Frank HILBERG , Christoph HOENKE , Matthias HOFFMANN , Maria IMPAGNATIELLO , Dirk KESSLER , Christian KLEIN , Bernd KRIST , Udo MAIER , Darryl McCONNELL , Charlotte REITHER , Stefan SCHEUERER , Andreas SCHOOP , Norbert SCHWEIFER , Oliver SIMON , Martin STEEGMAIER , Steffen STEURER , Irene WAIZENEGGER , Ulrike WEYER-CZERNILOFSKY , Andreas ZOEPHEL
发明人: Bodo BETZEMEIER , Trixi BRANDL , Steffen BREITFELDER , Ralph BRUECKNER , Thomas GERSTBERGER , Michael GMACHL , Matthias GRAUERT , Frank HILBERG , Christoph HOENKE , Matthias HOFFMANN , Maria IMPAGNATIELLO , Dirk KESSLER , Christian KLEIN , Bernd KRIST , Udo MAIER , Darryl McCONNELL , Charlotte REITHER , Stefan SCHEUERER , Andreas SCHOOP , Norbert SCHWEIFER , Oliver SIMON , Martin STEEGMAIER , Steffen STEURER , Irene WAIZENEGGER , Ulrike WEYER-CZERNILOFSKY , Andreas ZOEPHEL
IPC分类号: A61K31/397 , C07D417/14 , A61K31/4439 , C07D513/02 , A61K31/429 , C07D213/02 , A61K31/4545 , C07D401/14 , A61K31/444 , C07D403/02 , A61K31/497 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D267/10 , A61K31/553 , C07D223/02 , A61K31/55 , C07D243/08 , A61K31/551 , A61P35/00
CPC分类号: C07D513/04 , C07D277/84
摘要: The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要翻译: 本发明包括通式(1)的化合物,其中R 1至R 3如权利要求1中所定义,其适用于治疗特征为过度或异常细胞增殖的疾病,以及其用于制备具有上述 属性。
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公开(公告)号:US20130022572A1
公开(公告)日:2013-01-24
申请号:US13614902
申请日:2012-09-13
CPC分类号: C07K7/06 , A61K31/403 , A61K31/4439 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14 , C07K5/06165 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/10 , C07K5/101 , C07K5/1016
摘要: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译: 本申请描述了可用于治疗,预防和/或改善人类疾病的有机化合物。
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公开(公告)号:US20130034519A1
公开(公告)日:2013-02-07
申请号:US13614813
申请日:2012-09-13
CPC分类号: C07K7/06 , A61K31/403 , A61K31/4439 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14 , C07K5/06165 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/10 , C07K5/101 , C07K5/1016
摘要: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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公开(公告)号:US20090131424A1
公开(公告)日:2009-05-21
申请号:US12351017
申请日:2009-01-09
申请人: Trixi BRANDL , Udo MAIER , Christoph HOENKE , Anne T. JOERGENSEN , Alexander PAUTSCH , Steffen BREITFELDER , Matthias GRAUERT , Matthias HOFFMANN , Stefan SCHEUERER , Klaus ERB , Michael PIEPER , Ingo PRAGST
发明人: Trixi BRANDL , Udo MAIER , Christoph HOENKE , Anne T. JOERGENSEN , Alexander PAUTSCH , Steffen BREITFELDER , Matthias GRAUERT , Matthias HOFFMANN , Stefan SCHEUERER , Klaus ERB , Michael PIEPER , Ingo PRAGST
IPC分类号: A61K31/519 , C07D513/04 , A61P11/00 , A61P29/00 , A61P19/00 , A61K31/5377
CPC分类号: C07D513/04
摘要: Disclosed are compounds of general formula (I), wherein the groups A, R1, R2, Ra and Rb have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-quinazolines and the use thereof as pharmaceutical compositions.
摘要翻译: 公开了通式(I)的化合物,其中基团A,R 1,R 2,R a和R b具有权利要求书和说明书中给出的含义,互变异构体,外消旋体,对映体,非对映异构体及其混合物,以及任选的药理学上可接受的 酸加成盐,溶剂合物和水合物,以及制备这些噻唑基 - 二氢 - 喹唑啉的方法及其作为药物组合物的用途。
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公开(公告)号:US20110182850A1
公开(公告)日:2011-07-28
申请号:US12755856
申请日:2010-04-07
IPC分类号: A61K38/20 , C07D209/96 , C07D401/14 , C07D401/12 , C07D471/04 , C07D403/14 , C07D403/12 , C07D413/12 , A61K38/21 , A61K31/713 , A61K31/7036 , A61K31/437 , A61K31/7056 , A61K31/496 , A61K31/427 , A61K38/13 , A61K31/7048 , A61K31/403 , A61K31/454 , A61K31/4375 , A61K31/4184 , A61K31/497 , A61K31/5377 , A61P31/14
CPC分类号: C07D401/12 , A61K38/13 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , C07D403/12 , C07D413/12 , C07K5/101 , C07K7/06 , A61K2300/00
摘要: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译: 本申请描述了可用于治疗,预防和/或改善人类疾病的有机化合物。
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公开(公告)号:US20100260709A1
公开(公告)日:2010-10-14
申请号:US12755852
申请日:2010-04-07
IPC分类号: A61K38/20 , C07D209/54 , C07D211/18 , C07D273/01 , A61K31/4025 , A61K31/4439 , A61K31/497 , A61K31/5377 , A61K38/21 , A61K31/713 , A61K31/437 , A61K31/7056 , A61K31/7036 , A61K31/7076 , A61K31/496 , A61K38/13 , A61K31/7105 , A61P31/20
CPC分类号: C07K7/06 , A61K31/403 , A61K31/4439 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14 , C07K5/06165 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/10 , C07K5/101 , C07K5/1016
摘要: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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10.
公开(公告)号:US20100204211A1
公开(公告)日:2010-08-12
申请号:US12645151
申请日:2009-12-22
申请人: John Edward PARK , Gerald Juergen ROTH , Armin HECKEL , Nveed CHAUDHARY , Trixi BRANDL , Georg DAHMANN , Matthias GRAUERT
发明人: John Edward PARK , Gerald Juergen ROTH , Armin HECKEL , Nveed CHAUDHARY , Trixi BRANDL , Georg DAHMANN , Matthias GRAUERT
IPC分类号: A61K31/496 , A61K31/404 , A61K31/551 , A61K31/5377 , A61P11/00
CPC分类号: A61K31/4045 , A61K31/404 , A61K31/4178 , A61K31/44 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D209/34 , C07D295/155 , C07D295/215 , C07D401/12 , C07D403/12 , A61K2300/00
摘要: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.
摘要翻译: 本发明涉及在6位上被取代的通式的二氢吲哚酮的用途,其中R 1至R 5和X如权利要求1中所定义,其异构体及其盐,特别是其生理上可接受的盐作为药物用于 预防或治疗特定的纤维化疾病。
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