专利检索 ap:("Trustees of Dartmouth College" OR "Osteoscreen, Inc." OR "The Regents of the University of California" OR "Rutgers, The State University of new Jersey") AND inv:"Michael B. SPORN" 第 1 页

1.

发明申请
SYNTHETIC TRITERPENOIDS AND TRICYCLIC-BIS-ENONES FOR USE IN STIMULATING BONE AND CARTILAGE GROWTH 审中-公开
标题翻译：用于刺激骨骼和体重增长的合成三磷酸酯和三聚体双酚A

公开(公告)号：US20130122053A1

公开(公告)日：2013-05-16

申请号：US13625527

申请日：2012-09-24

申请人： Trustees of Dartmouth College , Osteoscreen, Inc. , The Regents of the University of California , Rutgers, The State University of new Jersey

发明人： Michael B. SPORN , Karen T. Liby , Tadashi Honda , Gregory Mundy , Ross Garrett , Hari Reddi , Gordon W. Gribble , Takahiro Niikura , Nanjoo Suh

IPC分类号： A61K31/4164 , A61K38/18 , A61K35/32 , A61K31/277 , A61K9/00

CPC分类号： A61K31/4164 , A61K9/00 , A61K31/26 , A61K31/277 , A61K35/32 , A61K38/1841 , C12N5/0655 , C12N2501/999 , Y02A50/395 , A61K2300/00

摘要： The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.

摘要翻译： 本发明涉及使用合成三萜类化合物和三环双酮来刺激骨和软骨的生长和修复的方法。合适的三萜类化合物的实例包括CDDO，CDDO-Me，CDDO-Im和CDDO-乙酰胺。三环双酮的实例包括TBE-31和TBE-34。

2.

发明申请
SYNTHETIC TRITERPENOIDS AND METHODS OF USE IN THE TREATMENT OF DISEASE 有权

公开(公告)号：US20130345276A1

公开(公告)日：2013-12-26

申请号：US13886053

申请日：2013-05-02

申请人： REATA PHARMACEUTICALS, INC. , TRUSTEES OF DARTMOUTH COLLEGE

发明人： Michael B. SPORN , Karen T. LIBY , Gordon W. GRIBBLE , Tadashi HONDA , Robert M. KRAL , Colin J. MEYER

IPC分类号： A61K31/4174 , A61K31/277

CPC分类号： A61K31/4174 , A61K31/275 , A61K31/277 , A61K31/4164 , A61K2300/00

摘要： The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.

3.

发明申请
SYNTHETIC TRITERPENOIDS AND METHODS OF USE IN THE TREATMENT OF DISEASE 审中-公开

公开(公告)号：US20180161311A1

公开(公告)日：2018-06-14

申请号：US15675862

申请日：2017-08-14

申请人： REATA PHARMACEUTICALS, INC. , TRUSTEES OF DARTMOUTH COLLEGE

发明人： Michael B. SPORN , Karen T. LIBY , Gordon W. GRIBBLE , Tadashi HONDA , Robert M. Kral , Colin J. MEYER

IPC分类号： A61K31/4174 , A61K31/277 , A61K31/4164 , A61K31/275

CPC分类号： A61K31/4174 , A61K31/275 , A61K31/277 , A61K31/4164 , A61K2300/00

摘要： The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.

4.

发明申请
THERAPEUTIC COMPOUNDS AND METHODS OF USE 有权
标题翻译：治疗化合物及其使用方法

公开(公告)号：US20140275618A1

公开(公告)日：2014-09-18

申请号：US14059185

申请日：2013-10-21

申请人： TRUSTEES OF DARTMOUTH COLLEGE

发明人： Gordon W. GRIBBLE , Tadashi HONDA , Michael B. SPORN , Nanjoo SUH

IPC分类号： C07C255/47

CPC分类号： C07C255/47 , A61K31/19 , A61K31/275 , A61K31/277 , A61K31/35

摘要： Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.

摘要翻译： 用于化学预防性治疗诸如癌症，阿尔茨海默氏病，帕金森病，炎性肠病和多发性硬化症的化合物和方法。