公开(公告)号：US4970305A

公开(公告)日：1990-11-13

申请号：US413915

申请日：1989-09-28

申请人： Tsuneo Okonogi ,  Yasushi Murai ,  Masahiro Onodera ,  Toshio Nishizuka ,  Yasuhiko Abat ,  Seiji Shibahara ,  Shigeharu Inouye

发明人： Tsuneo Okonogi ,  Yasushi Murai ,  Masahiro Onodera ,  Toshio Nishizuka ,  Yasuhiko Abat ,  Seiji Shibahara ,  Shigeharu Inouye

IPC分类号： C07D501/00 ,  A61K31/545 ,  C07D501/36

CPC分类号： C07D501/36 ,  Y02P20/55

摘要： The crystalline dihydrochloride of a specific cephalosporin derivative is stable to heat and retains its antibacterial activity even after storage over long periods at high temperature. The crystalline dihydrochloride can be obtained by removing protective groups from the cephalosporin derivative wherein the amino group and carboxy groups are protected and then crystallizing the cephalosporin derivative from a hydrochloric acid aqueous solution. The crystalline dihydrochloride is useful for pharmaceutical preparations.

公开(公告)号：US06441162B2

公开(公告)日：2002-08-27

申请号：US09854462

申请日：2001-05-15

申请人： Kiyoshi Yasui ,  Masahiro Onodera ,  Masamichi Sukegawa ,  Tatsuo Watanabe ,  Yuichi Yamamoto ,  Yasushi Murai ,  Katsuharu Iinuma

发明人： Kiyoshi Yasui ,  Masahiro Onodera ,  Masamichi Sukegawa ,  Tatsuo Watanabe ,  Yuichi Yamamoto ,  Yasushi Murai ,  Katsuharu Iinuma

IPC分类号： C07D50124

CPC分类号： C07D501/00

摘要： A crystalline substance of Cefditoren pivoxyl is provided which has a high purity and enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving an amorphous form of Cefditoren pivoxyl in an anhydrous, first organic solvent capable of dissolving said amorphous form well therein, and steps of replacing the first organic solvent component of the resulting solution by an anhydrous alkanol of 1 to 5 carbon atoms as a second organic solvent, in such a manner that the firstly prepared solution of Cefditoren pivoxyl in the first organic solvent is mixed with a volume of the alkanol and then is concentrated below 15° C. under reduced pressure, and so on. Thereby, the process proceeds so as to produce a solution containing 50 mg/ml to 250 mg/ml of Cefditoren pivoxyl dissolved in the alkanol alone. From the latter solution, crystals of Cefditoren pivoxyl are induced to deposit by addition of water at a temperature of 0-10° C. The resulting admixture of the concentrated solution of Cefditoren pivoxyl in alkanol with added water and the deposited Cefditoren pivoxyl is then agitated 10° C. or below, to effect a complete crystallization of Cefditoren pivoxyl.

摘要翻译： 提供了新戊酸头孢托仑的结晶物质，其具有高纯度和增强的储存热稳定性。 这种结晶的头孢托仑新戊基可以通过包括以下步骤的方法来制备，该方法包括将无定形形式的新戊酰氧基头孢托仑溶解在能够将所述无定形形式溶解在其中的无水第一有机溶剂中，以及将所得溶液的第一有机溶剂组分 通过具有1至5个碳原子的无水链烷醇作为第二有机溶剂，使得将首先制备的在第一有机溶剂中的新戊酰氧基头孢托仑的溶液与一定体积的链烷醇混合，然后浓缩至15℃以下。 减压下等。 由此，进行处理，从而产生溶解在单独的链烷醇中的含有50mg / ml〜250mg / ml的新戊酰氧基甲基头孢地托仑的溶液。 从后一种溶液中，通过在0-10℃的温度下，通过加入水诱导新戊酸头孢托仑的晶体沉淀。然后搅拌所得的新戊酰氧基甲基头孢地托仑在链烷醇中与加入的水的混合物和沉积的新戊糖酯 10℃或更低，以实现新戊酰氧基甲基头孢托仑的完全结晶。

公开(公告)号：US06294669B1

公开(公告)日：2001-09-25

申请号：US09269109

申请日：1999-03-19

申请人： Kiyoshi Yasui ,  Masahiro Onodera ,  Masamichi Sukegawa ,  Tatsuo Watanabe ,  Yuichi Yamamoto ,  Yasushi Murai ,  Katsuharu Iinuma

发明人： Kiyoshi Yasui ,  Masahiro Onodera ,  Masamichi Sukegawa ,  Tatsuo Watanabe ,  Yuichi Yamamoto ,  Yasushi Murai ,  Katsuharu Iinuma

IPC分类号： C07D50124

CPC分类号： C07D501/00

摘要： As a novel substance is provided such a new, crystalline substance of Cefditoren povoxyl which has a high purity and an enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving amorphous substance of Cefditoren pivoxyl in an anhydrous, first organic solvent capable of dissolving said amorphous substance well therein, and steps of replacing the first organic solvent component of the resulting solution by an anhydrous alkanol of 1 to 5 carbon atoms as a second organic solvent, in such a manner that the firstly prepared solution of Cefditoren pivoxyl in the first organic solvent is mixed with a volume of the alkanol and then is concentrated below 15° C. under reduced pressure, and so on. Thereby, the process proceeds so as to produce a solution containing 50 mg/ml to 250 mg/ml of Cefditoren pivoxyl dissolved in the alkanol alone. From the latter solution, crystals of Cefditoren pivoxyl are induced to deposit by addition of water at a temperature of 0-10° C. The resulting admixture of the concentrated solution of Cefditoren pivoxyl in alkanol with added water and the deposited Cefditoren pivoxyl is then agitated 10° C. or below, to effect a complete crystallization of Cefditoren pivoxyl.

摘要翻译： 作为一种新物质，提供了这样一种具有高纯度和增加的储存热稳定性的新型头孢托仑聚氧乙烯醚的结晶物质。 这种结晶的头孢托仑新戊基可以通过包括以下步骤的方法来制备，所述方法包括将能够将所述无定形物质溶解在其中的无水的第一有机溶剂中溶解新戊酰氧基甲基头孢托仑的无定形物质，以及将所得溶液的第一有机溶剂组分置换为 将具有1至5个碳原子的无水链烷醇作为第二有机溶剂，使得将首先制备的在第一有机溶剂中的新戊酰氧基头孢托仑的溶液与一定体积的链烷醇混合，然后在15℃以下浓缩 减压等。 由此，进行处理，从而产生溶解在单独的链烷醇中的含有50mg / ml〜250mg / ml的新戊酰氧基甲基头孢地托仑的溶液。 从后一种溶液中，通过在0-10℃的温度下，通过加入水诱导新戊酸头孢托仑的晶体沉淀。然后搅拌所得的新戊酰氧基甲基头孢地托仑在链烷醇中与加入的水的混合物和沉积的新戊糖酯 10℃或更低，以实现新戊酰氧基甲基头孢托仑的完全结晶。

公开(公告)号：US06486149B2

公开(公告)日：2002-11-26

申请号：US09991694

申请日：2001-11-26

申请人： Masahiro Onodera ,  Masamichi Sukegawa ,  Kiyoshi Yasui ,  Tatsuo Watanabe ,  Toyomi Sato ,  Yasushi Murai ,  Katsuharu Iinuma

发明人： Masahiro Onodera ,  Masamichi Sukegawa ,  Kiyoshi Yasui ,  Tatsuo Watanabe ,  Toyomi Sato ,  Yasushi Murai ,  Katsuharu Iinuma

IPC分类号： A61K31545

CPC分类号： C07D501/00 ,  A61K9/146 ,  A61K31/545 ,  A61K31/546 ,  Y10S514/96

摘要： Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren pivoxil substance with a water soluble high-molecular additive. These compositions can be produced by dissolving crystalline Cefditoren pivoxil substance and the water-soluble high-molecular additive in an aqueous solution of an acid, then neutralizing the resultant solution, to co-precipitate the product, and drying the thus precipitated product, followed by recovering the product in the form of the above-mentioned particles.

公开(公告)号：US06342493B1

公开(公告)日：2002-01-29

申请号：US09582937

申请日：2000-07-07

申请人： Masahiro Onodera ,  Masamichi Sukegawa ,  Kiyoshi Yasui ,  Tatsuo Watanabe ,  Toyomi Sato ,  Yasushi Murai ,  Katsuharu Iinuma

发明人： Masahiro Onodera ,  Masamichi Sukegawa ,  Kiyoshi Yasui ,  Tatsuo Watanabe ,  Toyomi Sato ,  Yasushi Murai ,  Katsuharu Iinuma

IPC分类号： A61K31545

CPC分类号： C07D501/00 ,  A61K9/146 ,  A61K31/545 ,  A61K31/546 ,  Y10S514/96

摘要： Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren pivoxil substance with a water soluble high-molecular additive. These compositions can be produced by dissolving crystalline Cefditoren pivoxil substance and the water-soluble high-molecular additive in an aqueous solution of an acid, then neutralizing the resultant solution, to co-precipitate the product, and drying the thus precipitated product, followed by recovering the product in the form of the above-mentioned particles.

摘要翻译： 提供了制备可口服的黄色和粉末状组合物的方法，其基本上由由无定形头孢托仑匹酯与水溶性高分子添加剂的均匀混合物组成的颗粒组成。 这些组合物可以通过将结晶性匹戊头孢托仑物质和水溶性高分子添加剂溶解在酸的水溶液中，然后中和所得溶液，使产物共沉淀并干燥沉淀的产物，然后 以上述颗粒的形式回收产物。

公开(公告)号：US4393058A

公开(公告)日：1983-07-12

申请号：US188417

申请日：1980-09-18

申请人： Osamu Makabe ,  Yasushi Murai ,  Tuneo Okonogi ,  Masahiro Onodera ,  Yoshiyuki Koyama ,  Takashi Yoshida

发明人： Osamu Makabe ,  Yasushi Murai ,  Tuneo Okonogi ,  Masahiro Onodera ,  Yoshiyuki Koyama ,  Takashi Yoshida

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C45/71 ,  C07D213/80 ,  C07D213/82 ,  C07D213/85 ,  C07D501/36

CPC分类号： C07D213/80 ,  C07C45/71 ,  C07D213/82 ,  C07D213/85

摘要： Cephalosporin compounds, intermediate compounds therefor, and processes for preparation thereof are described; the compounds have the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 can each represent hydrogen, a hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted phenylalkoxy group; R.sub.3 represents hydrogen or a lower alkyl group; R.sub.4 represents hydrogen or a hydroxyl group; and R.sub.5 represents ##STR2## wherein R.sub.6 is hydrogen, a lower alkyl group, an aminoalkyl group, an aminoaralkyl group, a --(CH.sub.2).sub.n --SO.sub.3 Na group, or a --(CH.sub.2).sub.n --COR.sub.9 group [wherein R.sub.9 is a hydroxyl group, an OM group (wherein M is an alkali metal), an alkoxy group, or an ##STR3## group, (wherein R.sub.10 and R.sub.11, which may be the same or different, can represent hydrogen or an alkyl group), and n is 0 or an integer of from 1 to 4]; R.sub.7 is hydrogen, a lower alkyl group, an amino group, or a substituted or unsubstituted aryl group; and R.sub.8 represents hydrogen or a lower alkyl group; or, a pharmaceutically acceptable salt thereof.

摘要翻译： 描述头孢菌素化合物，其中间体化合物及其制备方法; 化合物具有式（I）其中R 1和R 2各自表示氢，羟基，低级烷氧基或取代或未取代的苯基烷氧基; R3表示氢或低级烷基; R4代表氢或羟基; 其中R6为氢，低级烷基，氨基烷基，氨基烷基， - （CH2）n-SO3Na基或 - （CH2）n-COR9基[ 其中R 9为羟基，OM基（其中M为碱金属），烷氧基或基团（其中R10和R11可以相同或不同，表示氢或烷基 组），n为0或1〜4的整数]。 R7是氢，低级烷基，氨基或取代或未取代的芳基; R8代表氢或低级烷基; 或其药学上可接受的盐。

公开(公告)号：US4331597A

公开(公告)日：1982-05-25

申请号：US193317

申请日：1980-10-02

申请人： Osamu Makabe ,  Yasushi Murai ,  Tuneo Okonogi ,  Masahiro Onodera ,  Takashi Yoshida ,  Shunzo Fukatsu

发明人： Osamu Makabe ,  Yasushi Murai ,  Tuneo Okonogi ,  Masahiro Onodera ,  Takashi Yoshida ,  Shunzo Fukatsu

IPC分类号： A61K31/43 ,  A61P31/04 ,  C07D499/00 ,  C07D499/64 ,  C07D499/68 ,  C07D499/70

CPC分类号： C07D499/00

摘要： Penicillin compounds and methods for the production thereof are described, said penicillin compounds being represented by the formula (I) ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 each represents hydrogen, a lower alkyl group, a halogen atom, a lower alkoxy group, a hydroxyl group, or a substituted or unsubstituted phenylalkoxy group except that R.sub.1, R.sub.2, and R.sub.3 cannot all represent hydrogen simultaneously; R.sub.4 represents hydrogen or a lower alkyl group; and R.sub.5 represents hydrogen or a hydroxyl group.

摘要翻译： 描述了青霉素化合物及其制备方法，所述青霉素化合物由式（I）表示：其中R 1，R 2和R 3各自表示氢，低级烷基，卤原子，低级 烷氧基，羟基或取代或未取代的苯基烷氧基，除了R1，R2和R3不能全部同时代表氢; R4代表氢或低级烷基; R5表示氢或羟基。

公开(公告)号：US6041204A

公开(公告)日：2000-03-21

申请号：US223701

申请日：1998-12-30

申请人： Satoshi Haneda ,  Hiroyuki Tokimatsu ,  Masahiro Onodera ,  Shuta Hamada

发明人： Satoshi Haneda ,  Hiroyuki Tokimatsu ,  Masahiro Onodera ,  Shuta Hamada

IPC分类号： G03G15/01 ,  G03G15/16 ,  G03G21/00 ,  G03G15/00

CPC分类号： G03G15/0152 ,  G03G15/0168 ,  G03G15/169 ,  G03G21/0005 ,  G03G2215/017 ,  G03G2215/0187

摘要： In a color image forming apparatus provided with a photoreceptor having a rotatable peripheral surface; plural sets of a charging device, an imagewise exposure device, and a developing device, each set of the plural sets is provided separately from other sets around the peripheral surface of the photoreceptor so that plural color component images are formed one after another by the plural sets and are superimposed so as to form a color image on the peripheral surface during a single rotation of the peripheral surface. The developing device has a casing and the imagewise exposure device and the developing device of each set are arranged such that a portion on the peripheral surface locating at an imagewise exposing position moves into the casing of the developing device before the electric potential V1 of the portion is lowered to the half of V1 (V1/2). A pre-transfer exposing device/transfer device and pre-cleaning exposing device/cleaning device all operate such that the potential on the photoreceptor moves into the casings of the transfer device or cleaning device before the potential is lowered to half its value.

摘要翻译： 在具有可转动周边表面的感光体的彩色图像形成装置中， 多组充电装置，成像曝光装置以及显影装置，与感光体的周面周围的其他组分开设置多个组，使得多个分色图像依次形成为多个 并且叠加在外围表面的单次旋转期间在外围表面上形成彩色图像。 显影装置具有壳体，并且每个组的成像曝光装置和显影装置被布置成使得位于成像曝光位置的外周表面上的部分在该部分的电位V1之前移动到显影装置的壳体中 下降到V1的一半（V1 / 2）。 预转印曝光装置/转印装置和预清洁曝光装置/清洁装置全部操作，使得感光体上的电位在电位降低到其一半值之前移动到转印装置或清洁装置的壳体中。

公开(公告)号：US5886728A

公开(公告)日：1999-03-23

申请号：US755288

申请日：1996-11-22

申请人： Shuta Hamada ,  Satoshi Haneda ,  Hisayoshi Nagase ,  Hiroyuki Tokimatsu ,  Masahiro Onodera ,  Toshihide Miura

发明人： Shuta Hamada ,  Satoshi Haneda ,  Hisayoshi Nagase ,  Hiroyuki Tokimatsu ,  Masahiro Onodera ,  Toshihide Miura

IPC分类号： B41J2/447 ,  G03G15/32 ,  H04N1/50 ,  G03G15/01 ,  G01D15/14 ,  G03G15/04 ,  H04N1/29

CPC分类号： B41J2/4476 ,  G03G15/04081 ,  G03G15/326 ,  H04N1/506

摘要： An image forming apparatus has an image forming body which is rotatable in a subsidiary scanning direction. A plurality of imagewise exposure devices for imagewise exposing the image forming body are arranged to face the image forming body and to be aligned in a straight line in a primary scanning direction perpendicular to the subsidiary scanning direction of the image forming body. A common supporting member is provided for supporting the plurality of exposure devices, and bearing members are provided on first and second ends of the common supporting member. The plurality of exposure devices are: (i) radially arranged on the common supporting member with respect to a rotation axis of the image forming body, and (ii) fixed on the supporting member with respect to the bearing members, and the image forming body is rotatable against the common supporting member through the bearing members.

摘要翻译： 图像形成装置具有能够在副扫描方向上旋转的图像形成体。 多个用于成像曝光图像形成体的图像曝光装置被布置为面对图像形成体并且在垂直于成像体的辅助扫描方向的主扫描方向上以直线排列。 设置有用于支撑多个曝光装置的公共支撑构件，并且在公共支撑构件的第一和第二端上设置有支承构件​​。 多个曝光装置是：（i）相对于图像形成体的旋转轴径向地布置在公共支撑构件上，和（ii）相对于支承构件固定在支撑构件上，并且图像形成体 通过轴承部件能够相对于公共支撑部件转动。

公开(公告)号：US07359665B2

公开(公告)日：2008-04-15

申请号：US11284926

申请日：2005-11-23

申请人： Masahiro Onodera

发明人： Masahiro Onodera

IPC分类号： G03G15/20

CPC分类号： G03G15/2053 ,  G03G2215/00751 ,  G03G2215/2016 ,  G03G2215/2032

摘要： An image forming apparatus including: an image forming section to form a toner image on a recording sheet; a fixing device which has a fixing roller, an endless fixing belt trained with a tension about at least two rollers including the fixing roller, a heating device to heat the endless fixing belt, and a pressure roller to press the fixing roller through the endless belt, wherein the fixing device fixes the toner image on the recording sheet at a nip portion formed between the heated endless fixing belt and the pressure roller; a tension changing section to change the tension of the endless fixing belt; a recording sheet discriminating section to discriminate a type of recording sheet to be used; and a controller controling to make the tension changing section to change the tension of the fixing belt corresponding to the type of recording sheet.

摘要翻译： 一种图像形成装置，包括：图像形成部分，用于在记录纸上形成调色剂图像; 具有定影辊的定影装置，围绕包括定影辊的至少两个辊的张力训练的环形定影带，用于加热环形定影带的加热装置和加压辊，以通过环形带 其特征在于，所述固定装置将所述调色剂图像在形成于所述加热的环形定影带与所述加压辊之间的压合部固定在所述记录纸上; 张力改变部分，用于改变环形定影带的张力; 记录纸识别部分，用于区分要使用的记录纸的类型; 以及控制器，用于使张力改变部分改变与记录片材的类型对应的定影带的张力。