公开(公告)号：US4539150A

公开(公告)日：1985-09-03

申请号：US625656

申请日：1984-06-28

申请人： Tsutomu Katakami ,  Nobuyuki Fukazawa ,  Hajime Iizuka ,  Takashi Nishina ,  Isao Shirakawa

发明人： Tsutomu Katakami ,  Nobuyuki Fukazawa ,  Hajime Iizuka ,  Takashi Nishina ,  Isao Shirakawa

IPC分类号： C07D281/10 ,  C07D281/02

CPC分类号： C07D281/10

摘要： This invention relates to benzothiazepine derivatives of the general formula ##STR1## where K is hydrogen or a --CH.sub.2 COOR.sub.2 group where R.sub.2 is hydrogen or a lower alkyl group, Z is hydrogen or phenyl except when both K and Z are hydrogen, and Y is hydrogen, a --CHR.sub.3 --COOR.sub.1 group, an alkanoyl group or a --COO(CH.sub.2).sub.n R.sub.4 group where R.sub.1 is hydrogen or a lower alkyl group, R.sub.3 is hydrogen, an alkyl group, an alkylphenyl group or an aryl-lower alkyl group, R.sub.4 is an aryl group and n is a whole number of 1 to 10, and to their methods of preparation.The benzothiazepine derivatives of this invention, including their salts, have a powerful inhibitory effect on the angiotensin converting enzyme and exert a marked depressor effect in such models of hypertension as spontaneously occurring hypertensive rats and the like, so that they are useful as drugs for the treatment of hypertension and other cardiovascular diseases. In addition, these compounds are also useful as intermediates for the synthesis of coronary dilators, psychotropic drugs and the like.

摘要翻译： 本发明涉及通式为（I）的苯并硫氮杂衍生物，其中K是氢或-CH 2 COOR 2基团，其中R 2是氢或低级烷基，Z是氢或苯基，除了当K和Z都是氢时， Y是氢，-CHR 3 -COOR 1基团，烷酰基或-COO（CH 2）n R 4基团，其中R 1是氢或低级烷基，R 3是氢，烷基，烷基苯基或芳基 - 低级烷基 基团，R 4为芳基，n为1〜10的整数，及其制备方法。 包括其盐在内的本发明的苯并硫氮杂衍生物对血管紧张素转化酶具有强大的抑制作用，并且在自发发生的高血压大鼠等高血压模型中发挥明显的抑制作用，因此它们可用作药物 治疗高血压等心血管疾病。 此外，这些化合物也可用作合成冠状动脉扩张剂，精神药物等的中间体。

公开(公告)号：US07164439B2

公开(公告)日：2007-01-16

申请号：US10327892

申请日：2002-12-26

申请人： Takuji Yoshida ,  Katsuji Kimura ,  Noboru Kubo ,  Hiroyuki Okuhata ,  Toshiyuki Kaya ,  Shinsuke Hamanaka ,  Eiji Ono ,  Isao Shirakawa

发明人： Takuji Yoshida ,  Katsuji Kimura ,  Noboru Kubo ,  Hiroyuki Okuhata ,  Toshiyuki Kaya ,  Shinsuke Hamanaka ,  Eiji Ono ,  Isao Shirakawa

IPC分类号： H04N9/73 ,  H04N5/228

CPC分类号： H04N5/2357 ,  H04N5/235 ,  Y10S348/91

摘要： A flicker correction apparatus for correcting a flicker component of an image signal obtained by imaging an object using an imaging device is provided. The apparatus comprises an image average calculation section for calculating an average of the image signal, a flicker frequency calculation section for calculating a flicker frequency, a flicker data extraction section for extracting flicker data using the average of the image signal and the flicker frequency, a flicker determination section for determining the presence or absence of a flicker phenomenon using the flicker data, a flicker correction amount calculation section for calculating a flicker correction amount using the flicker data, and a flicker correction section for removing the flicker component of the image data using the flicker correction amount.

摘要翻译： 提供一种用于校正通过使用成像装置对物体成像而获得的图像信号的闪烁分量的闪烁校正装置。 该装置包括用于计算图像信号的平均值的图像平均计算部分，用于计算闪烁频率的闪烁频率计算部分，使用图像信号的平均值和闪烁频率来提取闪烁数据的闪烁数据提取部分， 闪烁确定部分，用于使用闪烁数据确定闪烁现象的存在或不存在;闪烁校正量计算部分，用于使用闪烁数据计算闪烁校正量;以及闪烁校正部分，用于使用以下方式去除图像数据的闪烁分量： 闪烁校正量。