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公开(公告)号：US11944717B2
公开(公告)日：2024-04-02
申请号：US17477947
申请日：2021-09-17
IPC分类号： A61B17/11 , A61B17/00 , A61F2/00 , A61F2/02 , A61K9/00 , A61L27/18 , A61L27/26 , A61L27/52 , A61L31/14
CPC分类号： A61L27/26 , A61B17/1128 , A61F2/00 , A61F2/02 , A61K9/0004 , A61L27/18 , A61L27/52 , A61L31/14 , A61B2017/00526 , A61F2210/00 , A61F2210/008 , A61F2240/00 , A61F2240/001 , A61F2250/00 , A61L2400/06 , A61L2430/32
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.
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公开(公告)号：US20210361292A1
公开(公告)日：2021-11-25
申请号：US17388327
申请日：2021-07-29
发明人： Corinne Bright , Yong Ren , Ken Martin , Farhad Khosravi , Amarpreet S. Sawhney
摘要： Disclosed are methods, devices and materials for the in situ formation of an implant for treating a nerve. A treatment site on a nerve is positioned within a cavity defined by a form. A transformable media is introduced into the form cavity to surround the treatment site. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the treatment site. The implant may be a growth inhibiting nerve cap to inhibit neuroma formation following planned or traumatic nerve injury, a growth permissive conduit for facilitating reconnection of a severed nerve, or an anchor for stabilizing a pain management electrode with respect to a nerve. Access to the nerve treatment site may be open surgical or percutaneous.
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公开(公告)号：US11890393B2
公开(公告)日：2024-02-06
申请号：US17138703
申请日：2020-12-30
IPC分类号： A61B17/11 , A61F2/00 , A61F2/02 , A61K9/00 , A61L27/52 , A61L31/14 , A61B17/00 , A61L27/26 , A61L27/18
CPC分类号： A61L27/26 , A61B17/1128 , A61F2/00 , A61F2/02 , A61K9/0004 , A61L27/18 , A61L27/52 , A61L31/14 , A61B2017/00526 , A61F2210/00 , A61F2210/008 , A61F2240/00 , A61F2240/001 , A61F2250/00 , A61L2400/06 , A61L2430/32
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.
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公开(公告)号：US20220054705A1
公开(公告)日：2022-02-24
申请号：US17477947
申请日：2021-09-17
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth
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公开(公告)号：US12096941B2
公开(公告)日：2024-09-24
申请号：US17388327
申请日：2021-07-29
发明人： Corinne Bright , Yong Ren , Ken Martin , Farhad Khosravi , Amarpreet S. Sawhney
CPC分类号： A61B17/12181 , A61F2/0059 , A61F2/02 , A61F2/08 , A61L27/52
摘要： Disclosed are methods, devices and materials for the in situ formation of an implant for treating a nerve. A treatment site on a nerve is positioned within a cavity defined by a form. A transformable media is introduced into the form cavity to surround the treatment site. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the treatment site. The implant may be a growth inhibiting nerve cap to inhibit neuroma formation following planned or traumatic nerve injury, a growth permissive conduit for facilitating reconnection of a severed nerve, or an anchor for stabilizing a pain management electrode with respect to a nerve. Access to the nerve treatment site may be open surgical or percutaneous.
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公开(公告)号：US20220096711A1
公开(公告)日：2022-03-31
申请号：US17547583
申请日：2021-12-10
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth
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公开(公告)号：US20210315587A1
公开(公告)日：2021-10-14
申请号：US17148427
申请日：2021-01-13
发明人： Corinne Bright , Yong Ren , Ken Martin , Farhad Khosravi , Amarpreet S. Sawhney
摘要： Disclosed are methods, devices and materials for the in situ formation of an implant for treating a nerve. A treatment site on a nerve is positioned within a cavity defined by a form. A transformable media is introduced into the form cavity to surround the treatment site. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the treatment site. A hydrophilic characteristic of the media cooperates with a hydrophobic characteristic of the surface of the cavity to facilitate a rapid release of the implant from the cavity following the transformation. The implant may be a growth inhibiting nerve cap to inhibit neuroma formation following planned or traumatic nerve injury, a growth permissive conduit for facilitating reconnection of a severed nerve, or an anchor for stabilizing a pain management electrode with respect to a nerve. Access to the nerve treatment site may be open surgical or percutaneous.
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公开(公告)号：US20240091141A1
公开(公告)日：2024-03-21
申请号：US18477383
申请日：2023-09-28
发明人： Tim S. Jarrett , Mike Bassett , Corinne Bright , Yong Ren
CPC分类号： A61K9/0024 , A61K9/06 , A61K45/06
摘要： Methods, devices and materials are for a pharmaceutically acceptable implant system. The implant system may comprise a neuromodulating agent, solid particulate hydrogel particle, a carrier medium in a different physical phase, and in situ formation of a singular depot for sustained release of said agent.
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公开(公告)号：US20220409902A1
公开(公告)日：2022-12-29
申请号：US17863251
申请日：2022-07-12
发明人： Corinne Bright , Yong Ren , Ken Martin , Sophia Michela Campbell
摘要： Methods, devices and materials are for in situ formation of an implant for treating a nerve. A treatment site is positioned within a cavity defined by a form. The form may facilitate placement of a nerve stimulating device adjacent to the nerve to facilitate nerve regeneration. An in situ forming gel may be delivered in the form to surround the nerve. Access to the nerve treatment site may be open surgical or percutaneous.
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