公开(公告)号：US11859203B2

公开(公告)日：2024-01-02

申请号：US16768091

申请日：2018-11-29

Applicant: UCB BIOPHARMA SRL

Inventor： Valentine Chevallier ,  Nadine Kochanowski ,  Laetitia Malphettes ,  Vincent Adolphe Carol Cool

IPC: C12N5/00 ,  C07K16/46

CPC classification number: C12N5/0018 ,  C07K16/461 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/515 ,  C12N2500/32

Abstract: The present invention relates to methods for reducing the heterogeneity of a population of recombinant proteins produced in cell culture, said methods comprising growing host cells producing a recombinant protein in a cell culture medium wherein the cell culture medium comprises one or more cysteine/cystine analogs.