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    Sequence symmetric modified IgG4 bispecific antibodies
    1.
    发明授权
    Sequence symmetric modified IgG4 bispecific antibodies 有权

    公开(公告)号：US11059911B2

    公开(公告)日：2021-07-13

    申请号：US16242378

    申请日：2019-01-08

    申请人： UCB Biopharma SPRL

    发明人： David Paul Humphreys ,  Shirley Jane Peters

    IPC分类号： C07K16/46 ,  C07K16/00

    摘要： The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain:
    the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and
    optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

    Sequence symmetric modified IGG4 bispecific antibodies
    2.
    发明授权
    Sequence symmetric modified IGG4 bispecific antibodies 有权

    公开(公告)号：US10221251B2

    公开(公告)日：2019-03-05

    申请号：US14380309

    申请日：2013-02-22

    申请人： UCB Biopharma SPRL

    发明人： David Paul Humphreys ,  Shirley Jane Peters

    IPC分类号： C07K16/00 ,  C07K16/46

    摘要： The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain: the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

    Sequence Symmetric Modified IGG4 Bispecific Antibodies
    3.
    发明申请
    Sequence Symmetric Modified IGG4 Bispecific Antibodies 审中-公开

    公开(公告)号：US20190202937A1

    公开(公告)日：2019-07-04

    申请号：US16242378

    申请日：2019-01-08

    申请人： UCB Biopharma SPRL

    发明人： David Paul Humphreys ,  Shirley Jane Peters

    IPC分类号： C07K16/46 ,  C07K16/00

    CPC分类号： C07K16/468 ,  C07K16/00 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/522 ,  C07K2317/53

    摘要： The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain:the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.