公开(公告)号：US20140242625A1

公开(公告)日：2014-08-28

申请号：US14275055

申请日：2014-05-12

Applicant: UCB PHARMA, S.A.

Inventor： BRYAN JOHN SMITH ,  HELEN MARIE KIRKE

IPC: C12Q1/37

CPC classification number: C12Q1/37 ,  G01N33/6857 ,  G01N2333/96433

Abstract: A method of measuring acidic species generated by degradation of a Fab or Fab′ component of a Fab-PEG or a Fab′-PEG is provided. The method involves: a) cleaving PEG and a linker from the Fab-PEG or Fab′-PEG with an enzyme; b) optionally separating the PEG and linker from the Fab or Fab′ to provide isolated Fab or Fab′; and c) quantitatively analyzing acidic species associated with the cleaved Fab or Fab′ and/or the cleaved PEG.

Abstract translation: 提供了测量由Fab-PEG或Fab'-PEG的Fab或Fab'成分降解而产生的酸性物质的方法。 该方法包括：a）用酶切割PEG和Fab-PEG或Fab'-PEG的接头; b）任选地将PEG和接头与Fab或Fab'分离以提供分离的Fab或Fab'; 和c）定量分析与切割的Fab或Fab'和/或切割的PEG相关的酸性物质。

公开(公告)号：US20140178387A1

公开(公告)日：2014-06-26

申请号：US14186074

申请日：2014-02-21

Applicant: UCB Pharma S.A.

Inventor： NEIL GOZZARD ,  ALASTAIR DAVID GRIFFITHS LAWSON ,  DANIEL JOHN LIGHTWOOD ,  ROGER THOMAS PALFRAMAN ,  BRYAN JOHN SMITH ,  KERRY LOUISE TYSON

IPC: C07K16/24

CPC classification number: C07K16/244 ,  A61K9/0078 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/544 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Abstract translation: 本发明涉及对人IL-13的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。