公开(公告)号：US20240344031A1

公开(公告)日：2024-10-17

申请号：US18682918

申请日：2022-08-02

Applicant: UNIVERSITÄT BASEL

Inventor： Sebastien PIGEOT ,  Ivan MARTIN ,  Paul BOURGINE

IPC: C12N5/0775 ,  C07K14/51 ,  C12N5/077 ,  C12N9/12 ,  C12N9/64

CPC classification number: C12N5/0662 ,  C07K14/51 ,  C12N5/0655 ,  C12N9/1276 ,  C12N9/6472 ,  C12N2506/1346 ,  C12N2510/00 ,  C12N2533/90 ,  C12Y207/07049 ,  C12Y304/22036

Abstract: A mesenchymal stem/stromal (MSC) cell line, in particular a human mesenchymal stem cell (hMSC), capable of chondrogenic differentiation when cultured in a chondrogenic medium, comprising a first transgene comprising a first nucleic acid sequence encoding for a preferably mammalian immortalizing enzyme under control of a first promoter sequence operable in said mesenchymal cell and a second transgene comprising a second nucleic acid sequence encoding a preferably mammalian bone morphogenic protein under control of a second promoter sequence operable in said mesenchymal cell.