公开(公告)号：US20160228233A1

公开(公告)日：2016-08-11

申请号：US15022212

申请日：2014-09-18

Applicant: UNIVERSITÄTSSPITAL BASEL

Inventor： Bernhard WINKLER ,  Martin GRAPOW ,  Friedrich ECKSTEIN ,  Aldo FERRARI ,  Dimos POULIKAKOS ,  Maximilian FISCHER ,  Tobias LENDENMANN

IPC: A61F2/06 ,  C12N1/20 ,  A61F2/90

CPC classification number: A61F2/06 ,  A61F2/062 ,  A61F2/07 ,  A61F2/90 ,  A61F2002/0086 ,  A61F2002/068 ,  A61F2002/072 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2250/0026 ,  A61F2250/003 ,  A61F2250/0051 ,  A61F2310/00011 ,  A61F2310/00982 ,  C12N1/20

Abstract: The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.

Abstract translation: 本发明涉及一种人造血管移植物，其包括包含人造血管移植物的内部空间的主要支架结构，所述主要支架结构具有面向所述内部空间的内表面和背离所述内部空间的外表面， 所述内表面，其中在所述内表面的所述涂层中包括多个凹槽。 主支架结构还包括在所述外表面上的涂层。 所述内表面和所述外表面上的主要支架结构和涂层的设计使得细胞，特别是祖细胞可以从所述人造血管移植物的周边迁移穿过所述涂层的外表面，所述 主要支架结构和所述内表面到所述内部空间，如果人造血管移植物按预期使用。 本发明进一步涉及提供所述移植物的方法。

公开(公告)号：US20190159880A1

公开(公告)日：2019-05-30

申请号：US16215690

申请日：2018-12-11

Applicant: UNIVERSITÄTSSPITAL BASEL

Inventor： Bernhard WINKLER ,  Martin GRAPOW ,  Friedrich ECKSTEIN ,  Aldo FERRARI ,  Dimos POULIKAKOS ,  Simone BOTTAN ,  Maximilian FISCHER ,  Tobias LENDENMANN

IPC: A61F2/06 ,  A61F2/07 ,  C12N1/20 ,  A61F2/90

Abstract: The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.