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公开(公告)号：US10188499B2
公开(公告)日：2019-01-29
申请号：US15022212
申请日：2014-09-18
发明人： Bernhard Winkler , Martin Grapow , Friedrich Eckstein , Aldo Ferrari , Dimos Poulikakos , Simone Bottan , Maximilian Fischer , Tobias Lendenmann
摘要： The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.
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公开(公告)号：US11648103B2
公开(公告)日：2023-05-16
申请号：US16215690
申请日：2018-12-11
发明人： Bernhard Winkler , Martin Grapow , Friedrich Eckstein , Aldo Ferrari , Dimos Poulikakos , Simone Bottan , Maximilian Fischer , Tobias Lendenmann
CPC分类号： A61F2/07 , A61F2/06 , A61F2/062 , A61F2/90 , A61F2002/0086 , A61F2002/068 , A61F2002/072 , A61F2210/0014 , A61F2210/0076 , A61F2250/003 , A61F2250/0026 , A61F2250/0051 , A61F2310/00011 , A61F2310/00982 , C12N1/20
摘要： The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.
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