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公开(公告)号：US20160045593A1
公开(公告)日：2016-02-18
申请号：US14832863
申请日：2015-08-21
发明人： Luc Willems , Karina Trono
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2740/14021 , C12N2740/14022 , C12N2740/14034 , C12N2740/14043 , C12N2740/14062 , C12N2740/14071
摘要： The invention relates to recombinant bovine leukemia viruses that have an attenuated phenotype and comprise a combination of at least two specific mutations. The invention also provides recombinant nucleic acids encoding such viruses, vectors comprising such nucleic acids, and host cells comprising such nucleic acids or vectors. The recombinant attenuated BLV viruses, recombinant nucleic acids, vectors and host cells allow for the preparation of improved vaccines, in particular vaccines suitable for the prophylactic treatment of BLV-associated diseases in subjects. The invention further provides methods for treating BLV-associated diseases in subjects and pharmaceutical compositions suitable for use in these methods.
摘要翻译： 本发明涉及具有减毒表型并且包含至少两个特异性突变的组合的重组牛白血病病毒。 本发明还提供了编码这种病毒的重组核酸，包含这种核酸的载体和包含这种核酸或载体的宿主细胞。 重组减毒BLV病毒，重组核酸，载体和宿主细胞允许制备改进的疫苗，特别是适合预防性治疗受试者中与BLV相关的疾病的疫苗。 本发明还提供了治疗患有BLV相关疾病的方法和适用于这些方法的药物组合物。
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公开(公告)号：US20190000963A1
公开(公告)日：2019-01-03
申请号：US16006472
申请日：2018-06-12
发明人： Luc Willems , Karina Trono
摘要： The invention relates to recombinant bovine leukemia viruses that have an attenuated phenotype and comprise a combination of at least two specific mutations. The invention also provides recombinant nucleic acids encoding such viruses, vectors comprising such nucleic acids, and host cells comprising such nucleic acids or vectors. The recombinant attenuated BLV viruses, recombinant nucleic acids, vectors and host cells allow for the preparation of improved vaccines, in particular vaccines suitable for the prophylactic treatment of BLV-associated diseases in subjects. The invention further provides methods for treating BLV-associated diseases in subjects and pharmaceutical compositions suitable for use in these methods.
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公开(公告)号：US10029006B2
公开(公告)日：2018-07-24
申请号：US14832863
申请日：2015-08-21
发明人： Luc Willems , Karina Trono
IPC分类号： A61K39/21 , C07K14/005 , C12N7/00 , A61K39/12 , A61K39/00
摘要： The invention relates to recombinant bovine leukemia viruses that have an attenuated phenotype and comprise a combination of at least two specific mutations. The invention also provides recombinant nucleic acids encoding such viruses, vectors comprising such nucleic acids, and host cells comprising such nucleic acids or vectors. The recombinant attenuated BLV viruses, recombinant nucleic acids, vectors and host cells allow for the preparation of improved vaccines, in particular vaccines suitable for the prophylactic treatment of BLV-associated diseases in subjects. The invention further provides methods for treating BLV-associated diseases in subjects and pharmaceutical compositions suitable for use in these methods.
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公开(公告)号：US11154611B2
公开(公告)日：2021-10-26
申请号：US16006472
申请日：2018-06-12
发明人： Luc Willems , Karina Trono
IPC分类号： A61K39/21 , C07K14/005 , C12N7/00 , A61K39/12 , A61K39/00
摘要： The invention relates to recombinant bovine leukemia viruses that have an attenuated phenotype and comprise a combination of at least two specific mutations. The invention also provides recombinant nucleic acids encoding such viruses, vectors comprising such nucleic acids, and host cells comprising such nucleic acids or vectors. The recombinant attenuated BLV viruses, recombinant nucleic acids, vectors and host cells allow for the preparation of improved vaccines, in particular vaccines suitable for the prophylactic treatment of BLV-associated diseases in subjects. The invention further provides methods for treating BLV-associated diseases in subjects and pharmaceutical compositions suitable for use in these methods.
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