公开(公告)号：US20240307308A1

公开(公告)日：2024-09-19

申请号：US18578888

申请日：2022-07-12

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Gang ZHENG ,  Juan CHEN ,  Tiffany Thanh-Uyen HO ,  Jiachuan BU ,  Lili DING

IPC: A61K9/127 ,  A61K41/00 ,  A61K51/04 ,  A61K51/12

CPC classification number: A61K9/1272 ,  A61K41/0071 ,  A61K51/0497 ,  A61K51/1234

Abstract: There is described herein a bilayer nanovesicle comprising porphyrin-phospholipid conjugate and a chelator-fatty acid conjugate; wherein the chelator-fatty acid conjugate comprises an aminopolycarboxylic acid conjugated to a single chain fatty acid; and the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid.

公开(公告)号：US20250075210A1

公开(公告)日：2025-03-06

申请号：US18727889

申请日：2023-01-12

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Shiyan WANG ,  Gang ZHENG ,  Housheng HE ,  Yulin MO

IPC: C12N15/113 ,  A61K9/51 ,  A61P35/00

Abstract: There is described herein methods for the treatment of cancer in a subject comprising downregulating YTHDF1 or ARHGEF2 and also compounds and compositions for achieving the same.

公开(公告)号：US20220296731A1

公开(公告)日：2022-09-22

申请号：US17608911

申请日：2020-05-06

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Gang ZHENG ,  Juan CHEN ,  Wenxiu HOU ,  Jiachuan BU

IPC: A61K49/00 ,  A61K9/51 ,  A61K31/337 ,  A61K41/00

Abstract: There is described herein a nanoparticle comprising an outer shell comprising a porphyrin salt, an expanded porphyrin salt or an analog of porphyrin salt, around an inner oil core.

公开(公告)号：US20180104364A1

公开(公告)日：2018-04-19

申请号：US15567294

申请日：2016-04-14

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Gang ZHENG ,  Joseph KECA

IPC: A61K49/22 ,  C12P17/18 ,  C07D487/22 ,  C07F9/10 ,  C07F9/6561

Abstract: There is provided herein, a texaphyrin-phospholipid conjugate, wherein the texaphyrin-phospholipid conjugate comprises a texaphyrin, texaphyrin derivative or texaphyrin analog covalently attached to a lipid side chain of a phospholipid.