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公开(公告)号：US10434146B2
公开(公告)日：2019-10-08
申请号：US15171384
申请日：2016-06-02
Inventor： Kirk P. Conrad
Abstract: The subject invention relates to methods for improving a subject's vasculature to normalize maternal hemodynamics, particularly in subjects attempting to conceive via assisted reproductive technologies, and comprises increasing relaxin levels in a subject or increasing any one or more of: relaxin synthesis, relaxin receptor synthesis, relaxin binding to the relaxin receptor, or relaxin receptor activity.
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公开(公告)号：US09907833B2
公开(公告)日：2018-03-06
申请号：US14340858
申请日：2014-07-25
Inventor： Kirk P. Conrad
CPC classification number: A61K38/2221 , C12Q1/6876 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16 , G01N33/6893 , G01N2800/368
Abstract: The subject application relates to methods for treating a placental syndrome, wherein relaxin is administered during the late secretory/luteal (LS) phase of the menstrual cycle in women who have a propensity for developing the placental syndrome. In certain embodiments, administration of relaxin continues beyond the LS phase and into pregnancy.
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3.发明授权Use of relaxin to restore maternal physiology in pregnancies conceived by assisted reproductive technologies 有权使用松弛素来恢复由辅助生殖技术构思的怀孕中的产妇生理学公开(公告)号：US09381231B2
公开(公告)日：2016-07-05
申请号：US14049620
申请日：2013-10-09
Inventor： Kirk P. Conrad
CPC classification number: A61K38/2221 , A61K45/06 , A61K2300/00
Abstract: The subject invention relates to methods for improving a subject's vasculature to normalize maternal hemodynamics, particularly in subjects attempting to conceive via assisted reproductive technologies, and comprises increasing relaxin levels in a subject or increasing any one or more of: relaxin synthesis, relaxin receptor synthesis, relaxin binding to the relaxin receptor, or relaxin receptor activity.
Abstract translation: 本发明涉及用于改善受试者脉管系统以使母体血液动力学正常化的方法，特别是在试图通过辅助生殖技术设想的受试者中，包括增加受试者中的松弛素水平或增加以下中的一种或多种：松弛素合成，松弛素受体合成， 松弛素结合松弛素受体或松弛素受体活性。
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