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公开(公告)号:US20180208643A1
公开(公告)日:2018-07-26
申请号:US15924703
申请日:2018-03-19
发明人: Donna M. AMBROSINO , Gregory J. BABCOCK , Teresa BROERING , Robert GRAZIANO , Hector Javier HERNANDEZ , Israel LOWY , Robert MANDELL , Deborah MOLRINE , William D. THOMAS, Jr. , Hui-Fen ZHANG
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
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公开(公告)号:US20210269511A1
公开(公告)日:2021-09-02
申请号:US17022766
申请日:2020-09-16
发明人: Donna M. AMBROSINO , Gregory J. BABCOCK , Teresa BROERING , Robert GRAZIANO , Hector Javier HERNANDEZ , Israel LOWY , Robert MANDELL , Deborah MOLRINE , William D. THOMAS, Jr. , Hui-Fen ZHANG
IPC分类号: C07K16/12 , A61K39/08 , G01N33/569
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
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公开(公告)号:US20160152694A1
公开(公告)日:2016-06-02
申请号:US14926706
申请日:2015-10-29
发明人: Donna M. AMBROSINO , Gregory J. BABCOCK , Teresa BROERING , Robert GRAZIANO , Hector Javier HERNANDEZ , Israel LOWY , Robert MANDELL , Deborah MOLRINE , William D. THOMAS, JR. , Hui-Fen ZHANG
IPC分类号: C07K16/12
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译: 本文提供了特异性结合艰难梭菌毒素的抗体,其抗原结合部分,以及制备和使用抗体及其抗原结合部分的方法。
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公开(公告)号:US20140134175A1
公开(公告)日:2014-05-15
申请号:US14035172
申请日:2013-09-24
发明人: Donna M. AMBROSINO , William D. THOMAS, JR. , Gregory J. BABCOCK , Teresa BROERING , Susan SLOAN
IPC分类号: C07K16/10
CPC分类号: C07K16/109 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/505 , A61K2039/5258 , A61K2039/55566 , C07K14/005 , C07K2317/21 , C07K2317/34 , C12N2770/24222 , C12N2770/24234
摘要: Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译: 公开了与丙型肝炎病毒(HCV)结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体,非人转基因动物和产生人抗体的杂交瘤的药物组合物,以及使用人抗体的治疗和诊断方法。
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公开(公告)号:US20140120614A1
公开(公告)日:2014-05-01
申请号:US14080598
申请日:2013-11-14
发明人: Donna M. AMBROSINO , Gregory J. BABCOCK , Teresa BROERING , Robert GRAZIANO , Hector Javier HERNANDEZ , Israel LOWY , Robert MANDELL , Deborah MOLRINE , William D. THOMAS, JR. , Hui-Fen ZHANG
IPC分类号: C07K16/12
CPC分类号: C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译: 本文提供了特异性结合艰难梭菌毒素的抗体,其抗原结合部分,以及制备和使用抗体及其抗原结合部分的方法。
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