公开(公告)号：US20150065443A1

公开(公告)日：2015-03-05

申请号：US14391001

申请日：2013-04-04

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Song Li ,  Xiang Gao ,  Yixian Huang ,  Jianqin Lu

IPC分类号： A61K9/107 ,  A61K31/704 ,  A61K31/337 ,  A61K47/48 ,  A61K31/122

CPC分类号： A61K9/1075 ,  A61K31/122 ,  A61K31/337 ,  A61K31/436 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/7048 ,  A61K38/13 ,  A61K47/18 ,  A61K47/55 ,  A61K47/60 ,  A61K2300/00

摘要： A composition having a structure of: X-L-Y wherein X comprises at least one embelin moiety;L comprises a linker; andY comprises a hydrophilic moiety.Also disclosed is a micelle that includes:a core that includes at least one hydrophobic active agent and at least one embelin moiety; anda hydrophilic zone surrounding the core and comprising at least one hydrophilic moiety.

摘要翻译： 具有以下结构的组合物：X-L-Y，其中X包含至少一个连接子部分; L包含连接体; Y包含亲水部分。 还公开了一种胶束，其包括：核心，其包含至少一种疏水性活性剂和至少一种丝氨酸部分; 以及包围所述芯并且包含至少一个亲水部分的亲水区。

公开(公告)号：US20240131170A1

公开(公告)日：2024-04-25

申请号：US18540254

申请日：2023-12-14

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Song Li ,  Jingjing Sun ,  Yichao Chen ,  Yixian Huang ,  Yanhua Liu ,  Binfeng Lu

IPC分类号： A61K47/58 ,  A61K9/107 ,  A61K31/65 ,  A61K47/54 ,  C12N15/113

CPC分类号： A61K47/58 ,  A61K9/1075 ,  A61K31/65 ,  A61K47/549 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

摘要： A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.

公开(公告)号：US10376591B2

公开(公告)日：2019-08-13

申请号：US15703110

申请日：2017-09-13

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Song Li ,  Yixian Huang ,  Xiaolan Zhang ,  Xiang Gao

IPC分类号： A61K47/60 ,  A61K31/337 ,  A61K31/235 ,  A61K31/704 ,  A61K9/00 ,  A61K9/107 ,  C08G65/331 ,  C08G65/333 ,  C08G65/334

摘要： A formulation includes a carrier agent formed by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic compound, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS antagonist, wherein a plurality of the carrier agents are adapted to assemble into a structure and the at least one biologically active hydrophobic compound is conjugated with the at least one hydrophilic compound via a linkage which is labile in vivo, and a biologically active compound associated with the carrier agent.

公开(公告)号：US20230293553A1

公开(公告)日：2023-09-21

申请号：US18014867

申请日：2021-07-06

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Song Li ,  Yixian Huang ,  Haozhe Huang

IPC分类号： A61K31/606 ,  A61K31/704 ,  A61K47/34 ,  A61K9/107

CPC分类号： A61K31/606 ,  A61K31/704 ,  A61K47/34 ,  A61K9/1075

摘要： A polymer includes a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and including a first moiety including at least one group selected for ionic interaction with a second therapeutic agent, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer. The first moiety is attached via a labile bond and is released in vivo from the polymer to provide a biologically or therapeutically active form of a first therapeutic compounds.

公开(公告)号：US09855341B2

公开(公告)日：2018-01-02

申请号：US14625873

申请日：2015-02-19

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Song Li ,  Yixian Huang ,  Xiaolan Zhang ,  Xiang Gao

IPC分类号： A61K47/48 ,  A61K31/337 ,  A61K31/235 ,  A61K31/704 ,  A61K9/00 ,  A61K9/107 ,  C08G65/331 ,  C08G65/333 ,  C08G65/334

CPC分类号： A61K47/60 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/235 ,  A61K31/337 ,  A61K31/704 ,  C08G65/331 ,  C08G65/3311 ,  C08G65/33306 ,  C08G65/33396 ,  C08G65/334 ,  C08G65/3344 ,  C08L2203/02

摘要： A method of forming or creating a formulation for a compound to be delivered includes creating a carrier agent by conjugating at least one hydrophobic domain or hydrophobic compound with at least one hydrophilic domain or hydrophilic compound and associating the compound to be delivered with the carrier agent to create the formulation. The at least one hydrophobic compound has the formula: wherein R1 is a farnesyl group, a geranyl group or geranyl-geranyl group, X is O, S, SO, SO2, NH or Se, Z is C—R2 or N, R2 is H, CN, CO2R7, SO3R7, CONR7R8 or SO2NR7R8, wherein R7 and R8 are each independently H, an alkyl group, an alkenyl group, CO2M or SO3M, wherein M is a cation and R3, R4, and R5 are independently H, a carboxyl group, an alkyl group, an alkenyl group, an aminoalkyl group, a nitroalkyl group, a nitro group, a halo atom, an amino group, a mono-alkylamino group, a di-alkylamino group, mercapto group, a mercaptoalkyl group, an azido group or a thiocyanato group. A plurality of the carrier agents are adapted to assemble into a structure. The hydrophobic compound is cleavably conjugated to the at least one hydrophilic compound via a linkage which is labile in vivo.

公开(公告)号：US11857634B2

公开(公告)日：2024-01-02

申请号：US17049152

申请日：2019-04-20

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Song Li ,  Jingjing Sun ,  Yichao Chen ,  Yixian Huang ,  Yanhua Liu ,  Binfeng Lu

IPC分类号： A61K47/58 ,  A61K47/54 ,  A61K9/107 ,  A61K31/65 ,  C12N15/113

CPC分类号： A61K47/58 ,  A61K9/1075 ,  A61K31/65 ,  A61K47/549 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351

摘要： A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.

公开(公告)号：US20210236645A1

公开(公告)日：2021-08-05

申请号：US17049152

申请日：2019-04-20

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Song Li ,  Jingjing Sun ,  Yichao Chen ,  Yixian Huang ,  Yanhua Liu ,  Binfeng Lu

IPC分类号： A61K47/58 ,  A61K47/54 ,  C12N15/113 ,  A61K9/107 ,  A61K31/65

摘要： A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.

公开(公告)号：US20180214563A1

公开(公告)日：2018-08-02

申请号：US15748469

申请日：2016-07-28

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Song Li ,  Yichao Chen ,  Yixian Huang

IPC分类号： A61K47/60 ,  A61K47/69 ,  A61K45/06

CPC分类号： A61K47/60 ,  A61K31/337 ,  A61K31/4188 ,  A61K31/704 ,  A61K45/06 ,  A61K47/6907 ,  A61K2300/00

摘要： A formulation includes a carrier agent formed by conjugating an immunotherapy agent with a hydrophilic compound. The carrier agent further includes an interactive domain comprising at least one interactive moiety which interacts with a therapeutic agent.