公开(公告)号：US09510932B2

公开(公告)日：2016-12-06

申请号：US14349564

申请日：2012-10-05

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Prashant N. Kumta ,  Da-Tren Chou ,  Daeho Hong ,  Partha Saha

IPC分类号： A61F2/02 ,  C22C23/00 ,  C22C23/04 ,  C22C23/06 ,  C22C1/02 ,  C22F1/06 ,  A61L27/04 ,  A61L27/58 ,  A61K31/397 ,  A61K31/7036

CPC分类号： A61F2/02 ,  A61K31/397 ,  A61K31/7036 ,  A61L27/047 ,  A61L27/58 ,  C22C1/02 ,  C22C23/00 ,  C22C23/04 ,  C22C23/06 ,  C22F1/06

摘要： The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components, such as yttrium, calcium, silver, cerium, and zirconium; or zinc, silver, cerium, and zirconium; or aluminum, zinc, calcium, manganese, silver, yttrium; or strontium, calcium, zinc. The compositions are prepared by vacuum induction/crucible melting together the components and casting the melted mixture in a preheated mild steel/copper mold. In certain embodiments, the compositions of the invention are particularly useful for forming medical devices for implantation into a body of a patient.

摘要翻译： 本发明涉及可生物降解的含金属合金的组合物，其制备方法和应用。 组合物包括镁和其它组分，例如钇，钙，银，铈和锆; 或锌，银，铈和锆; 或铝，锌，钙，锰，银，钇; 或锶，钙，锌。 组合物通过真空诱导/坩埚将组分一起熔化并将熔融的混合物浇铸在预热的软钢/铜模具中来制备。 在某些实施方案中，本发明的组合物特别可用于形成用于植入患者体内的医疗装置。

公开(公告)号：US11696976B2

公开(公告)日：2023-07-11

申请号：US15750219

申请日：2016-08-22

申请人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Prashant N. Kumta ,  Abhijit Roy ,  Da-Tren Chou ,  Daeho Hong ,  Vijay S. Gorantla

IPC分类号： A61L31/14 ,  A61L31/02 ,  C22C23/04

CPC分类号： A61L31/148 ,  A61L31/022 ,  C22C23/04 ,  A61L2430/02

摘要： The invention relates to biodegradable, magnesium alloys, compositions and composites, methods for their preparation and applications for their use as implantable medical devices in load-bearing conditions. The magnesium alloys are composed of alloying elements selected from yttrium, calcium, zirconium, zinc, and strontium, with the remainder being magnesium and impurities due to production, and are prepared by melting together the elements and casting the resulting melted mixture. In certain embodiments, the methods of preparation include solution treatment and hot extrusion.

公开(公告)号：US10604827B2

公开(公告)日：2020-03-31

申请号：US15835538

申请日：2017-12-08

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Prashant N. Kumta ,  Da-Tren Chou ,  Daeho Hong ,  Partha Saha

IPC分类号： C22C23/06 ,  C22C1/02 ,  B22D21/00 ,  A61F2/02 ,  A61L27/04 ,  C22C1/06 ,  A61K31/7036 ,  C22C23/00 ,  C22C23/04 ,  A61L27/58 ,  A61K31/397 ,  A61L31/02 ,  A61L31/14

摘要： The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components, such as yttrium, calcium, silver, cerium, and zirconium; or zinc, silver, cerium, and zirconium; or aluminum, zinc, calcium, manganese, silver, yttrium; or strontium, calcium, zinc. The compositions are prepared by vacuum induction/crucible melting together the components and casting the melted mixture in a preheated mild steel/copper mold. In certain embodiments, the compositions of the invention are particularly useful for forming medical devices for implantation into a body of a patient.

公开(公告)号：US09863020B2

公开(公告)日：2018-01-09

申请号：US15337444

申请日：2016-10-28

申请人： UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Prashant N. Kumta ,  Da-Tren Chou ,  Daeho Hong ,  Partha Saha

IPC分类号： A61F2/02 ,  C22C23/00 ,  C22C23/04 ,  C22C23/06 ,  C22C1/02 ,  C22C1/06 ,  A61L27/04 ,  A61L27/58 ,  A61K31/397 ,  A61K31/7036 ,  B22D21/00 ,  A61L31/02 ,  A61L31/14

CPC分类号： C22C23/06 ,  A61F2/02 ,  A61K31/397 ,  A61K31/7036 ,  A61L27/047 ,  A61L27/58 ,  A61L31/022 ,  A61L31/148 ,  B22D21/007 ,  C22C1/02 ,  C22C1/06 ,  C22C23/00 ,  C22C23/04

摘要： The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components, such as yttrium, calcium, silver, cerium, and zirconium; or zinc, silver, cerium, and zirconium; or aluminum, zinc, calcium, manganese, silver, yttrium; or strontium, calcium, zinc. The compositions are prepared by vacuum induction/crucible melting together the components and casting the melted mixture in a preheated mild steel/copper mold. In certain embodiments, the compositions of the invention are particularly useful for forming medical devices for implantation into a body of a patient.

公开(公告)号：US20140248288A1

公开(公告)日：2014-09-04

申请号：US14349564

申请日：2012-10-05

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Prashant N. Kumta ,  Da-Tren Chou ,  Daeho Hong ,  Partha Saha

IPC分类号： A61F2/02 ,  A61K31/397 ,  A61K31/7036 ,  C22C23/00

CPC分类号： A61F2/02 ,  A61K31/397 ,  A61K31/7036 ,  A61L27/047 ,  A61L27/58 ,  C22C1/02 ,  C22C23/00 ,  C22C23/04 ,  C22C23/06 ,  C22F1/06

摘要： The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components, such as yttrium, calcium, silver, cerium, and zirconium; or zinc, silver, cerium, and zirconium; or aluminum, zinc, calcium, manganese, silver, yttrium; or strontium, calcium, zinc. The compositions are prepared by vacuum induction/crucible melting together the components and casting the melted mixture in a preheated mild steel/copper mold. In certain embodiments, the compositions of the invention are particularly useful for forming medical devices for implantation into a body of a patient.

摘要翻译： 本发明涉及可生物降解的含金属合金的组合物，其制备方法和应用。 组合物包括镁和其它组分，例如钇，钙，银，铈和锆; 或锌，银，铈和锆; 或铝，锌，钙，锰，银，钇; 或锶，钙，锌。 组合物通过真空诱导/坩埚将组分一起熔化并将熔融的混合物浇铸在预热的软钢/铜模具中来制备。 在某些实施方案中，本发明的组合物特别可用于形成用于植入患者体内的医疗装置。