公开(公告)号：US20200283431A1

公开(公告)日：2020-09-10

申请号：US16599354

申请日：2019-10-11

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Shudong WANG ,  Solomon Tadesse ZELEKE ,  Mingfeng YU

IPC: C07D417/14 ,  A61P35/02

Abstract: A novel class of inhibitors of protein kinases that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of CDK4, CDK6 and/or cyclin D, including certain cancers of lung, breast, brain central nervous system, colorectal cancer and leukaemias. The inhibitors have the general structure I:

公开(公告)号：US20230310427A1

公开(公告)日：2023-10-05

申请号：US18003733

申请日：2021-06-30

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Richard John HEAD ,  Shudong WANG ,  Md Saiful ISLAM ,  Malika KUMARASIRI

IPC: A61K31/505 ,  A61P35/00 ,  A61K31/337 ,  A61P15/08 ,  A61P13/08 ,  A61P35/02

CPC classification number: A61K31/505 ,  A61K31/337 ,  A61P13/08 ,  A61P15/08 ,  A61P35/00 ,  A61P35/02

Abstract: Methods and uses of Rilpivirine and analogues thereof in the treatment and/or prevention of proliferative cell diseases and conditions are disclosed. Among the diseases and conditions that may be treated and/or prevented, are cancers characterised by Aurora A dysregulation.

公开(公告)号：US20180222900A1

公开(公告)日：2018-08-09

申请号：US15749652

申请日：2016-08-04

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Shudong WANG ,  Solomon Tadesse ZELEKE ,  Mingfeng YU

IPC: C07D417/14 ,  A61P35/02

Abstract: A novel class of inhibitors of protein kinases that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of CDK4, CDK6 and/or cyclin D, including certain cancers of lung, breast, brain, central nervous system, colorectal cancer and leukaemias. The inhibitors have the general structure I: