公开(公告)号：US11866685B2

公开(公告)日：2024-01-09

申请号：US16939685

申请日：2020-07-27

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ehsan Jabbarzadeh ,  Christopher Wu

IPC: C12M1/34 ,  C12M1/12 ,  C12M1/42 ,  C12M1/00 ,  C12M1/32 ,  C08L33/26 ,  C08L33/10

CPC classification number: C12M41/12 ,  C12M23/20 ,  C12M25/14 ,  C12M35/02 ,  C12M35/04 ,  C08L33/10 ,  C08L33/26 ,  C12M23/12

Abstract: Biocompatible, mechanically-dynamic thermoresponsive devices, methods for forming the devices, and exemplary applications for the devices are described. The devices include a series of wells therein and provide for temperature-controlled mechanostimulation of single cells or groups of cells that can be retained in the wells of a device. Mechanostimulation can be single instance of any duration, continuous, or regular or irregular cyclic mechanostimulation of single cells, cell clusters, cell spheroids, or organoids and may be utilized in any of a variety of biomedical applications including, without limitation, cellular engineering, cellular phenotyping, and drug discovery/screening.