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公开(公告)号：US20240016890A1
公开(公告)日：2024-01-18
申请号：US18480362
申请日：2023-10-03
发明人： Joshua Schiffman , Avi Schroeder , Lisa Abegglen
IPC分类号： A61K38/17 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K45/06 , C07K14/47 , A61K9/51 , A61K48/00 , A61P35/00
CPC分类号： A61K38/1758 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K45/06 , C07K14/47 , A61K9/51 , C07K14/4746 , A61K48/00 , A61P35/00 , A61K9/5146
摘要： The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
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公开(公告)号：US20190070259A1
公开(公告)日：2019-03-07
申请号：US15767099
申请日：2016-10-07
发明人： Joshua Schiffman , Avi Schroeder , Lisa Abegglen
IPC分类号： A61K38/17 , A61K31/711 , A61K31/7105 , A61K9/51 , A61K9/127 , A61P35/00
摘要： The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
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公开(公告)号：US20200368316A1
公开(公告)日：2020-11-26
申请号：US16894698
申请日：2020-06-05
发明人： Joshua Schiffman , Avi Schroeder , Lisa Abegglen
IPC分类号： A61K38/17 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K45/06 , C07K14/47 , A61K9/51 , A61K48/00 , A61P35/00
摘要： The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
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公开(公告)号：US11833188B2
公开(公告)日：2023-12-05
申请号：US16894698
申请日：2020-06-05
发明人： Joshua Schiffman , Avi Schroeder , Lisa Abegglen
IPC分类号： A61K38/17 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K45/06 , C07K14/47 , A61K9/51 , A61K48/00 , A61P35/00
CPC分类号： A61K38/1758 , A61K9/127 , A61K9/51 , A61K9/5146 , A61K31/711 , A61K31/7105 , A61K45/06 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/4746
摘要： The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
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公开(公告)号：US10709761B2
公开(公告)日：2020-07-14
申请号：US15767099
申请日：2016-10-07
发明人： Joshua Schiffman , Avi Schroeder , Lisa Abegglen
IPC分类号： A61K38/17 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K45/06 , C07K14/47 , A61K9/51 , A61K48/00 , A61P35/00
摘要： The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
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公开(公告)号：US11096891B2
公开(公告)日：2021-08-24
申请号：US16311861
申请日：2017-06-21
发明人： Havazelet Bianco-Peled , Avi Schroeder , Shlomit Avidan-Shlomovich , Yarden Degani , Mor Goldfeder
IPC分类号： A61K9/00 , A61K47/36 , A61K9/06 , A61K33/243 , A61K9/127 , A61K31/513 , A61K31/704 , A61K39/395
摘要： A composition and method for the administration of therapeutic and/or diagnostic agents is provided. Specifically, a hybrid system, composed of polymer that harbors drug-loaded lipid nanoparticles, and use thereof for the administration of active agents e.g., anti-cancer agents, is provided.
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公开(公告)号：US11992557B2
公开(公告)日：2024-05-28
申请号：US16963648
申请日：2019-01-23
发明人： Avi Schroeder , Assaf Zinger
IPC分类号： A61K9/127 , A61K31/337 , A61K38/48 , A61P35/00
CPC分类号： A61K9/127 , A61K9/1277 , A61K31/337 , A61K38/4886 , A61P35/00 , C12Y304/24007
摘要： Pharmaceutical compositions comprising at least one lipid-based particle encapsulating a proteolytic enzyme and a pharmaceutically acceptable carrier, wherein the proteolytic enzyme comprises at least 75% proteolytically active enzyme are provided. Methods of using same and producing same are also provided.
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