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公开(公告)号：US10709761B2
公开(公告)日：2020-07-14
申请号：US15767099
申请日：2016-10-07
发明人： Joshua Schiffman , Avi Schroeder , Lisa Abegglen
IPC分类号： A61K38/17 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K45/06 , C07K14/47 , A61K9/51 , A61K48/00 , A61P35/00
摘要： The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
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公开(公告)号：US11833188B2
公开(公告)日：2023-12-05
申请号：US16894698
申请日：2020-06-05
发明人： Joshua Schiffman , Avi Schroeder , Lisa Abegglen
IPC分类号： A61K38/17 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K45/06 , C07K14/47 , A61K9/51 , A61K48/00 , A61P35/00
CPC分类号： A61K38/1758 , A61K9/127 , A61K9/51 , A61K9/5146 , A61K31/711 , A61K31/7105 , A61K45/06 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/4746
摘要： The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
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公开(公告)号：US20200368316A1
公开(公告)日：2020-11-26
申请号：US16894698
申请日：2020-06-05
发明人： Joshua Schiffman , Avi Schroeder , Lisa Abegglen
IPC分类号： A61K38/17 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K45/06 , C07K14/47 , A61K9/51 , A61K48/00 , A61P35/00
摘要： The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
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公开(公告)号：US20240016890A1
公开(公告)日：2024-01-18
申请号：US18480362
申请日：2023-10-03
发明人： Joshua Schiffman , Avi Schroeder , Lisa Abegglen
IPC分类号： A61K38/17 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K45/06 , C07K14/47 , A61K9/51 , A61K48/00 , A61P35/00
CPC分类号： A61K38/1758 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K45/06 , C07K14/47 , A61K9/51 , C07K14/4746 , A61K48/00 , A61P35/00 , A61K9/5146
摘要： The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
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公开(公告)号：US20190070259A1
公开(公告)日：2019-03-07
申请号：US15767099
申请日：2016-10-07
发明人： Joshua Schiffman , Avi Schroeder , Lisa Abegglen
IPC分类号： A61K38/17 , A61K31/711 , A61K31/7105 , A61K9/51 , A61K9/127 , A61P35/00
摘要： The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
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公开(公告)号：US20210138033A1
公开(公告)日：2021-05-13
申请号：US16908250
申请日：2020-06-22
摘要： Neonatal NET-inhibitory Factor (nNIF) and nNIF-Related Peptides (NRPs) are provided. Methods for the treatment of and prophylaxis against inflammatory disorders and cancer are also provided. Additionally, methods for the inhibition of metastasis in patients having cancer are provided. The methods can include administering nNIF and/or a NRP to patients having, or at risk of developing, an inflammatory disorder or a cancer.
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公开(公告)号：US10857201B2
公开(公告)日：2020-12-08
申请号：US16328697
申请日：2017-09-05
摘要： Neonatal NET-Inhibitory Factor (nNIF) and nNIF-Related Peptides (NRPs) are provided. Methods for the treatment of and prophylaxis against inflammatory disorders and cancer are also provided. Additionally, methods for the inhibition of metastasis in patients having cancer are provided. The methods can include administering nNIF and/or a NRP to patients having, or at risk of developing, an inflammatory disorder or a cancer.
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公开(公告)号：US11324801B2
公开(公告)日：2022-05-10
申请号：US16908250
申请日：2020-06-22
摘要： Neonatal NET-inhibitory Factor (nNIF) and nNIF-Related Peptides (NRPs) are provided. Methods for the treatment of and prophylaxis against inflammatory disorders and cancer are also provided. Additionally, methods for the inhibition of metastasis in patients having cancer are provided. The methods can include administering nNIF and/or a NRP to patients having, or at risk of developing, an inflammatory disorder or a cancer.
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