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公开(公告)号：US11248034B2
公开(公告)日：2022-02-15
申请号：US16319450
申请日：2017-07-21
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人： John Gerbrandt Tasman Menting , Brian Smith , Danny Hung-Chieh Chou , Helena Safavi-Hemami , Michael Colin Lawrence , Baldomero M. Olivera
摘要： The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
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公开(公告)号：US08735541B2
公开(公告)日：2014-05-27
申请号：US13911596
申请日：2013-06-06
CPC分类号： C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要： The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译： 本发明涉及相对较短的肽（本文称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括两个 二硫键。
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3.发明授权公开(公告)号：US09630997B2
公开(公告)日：2017-04-25
申请号：US14404919
申请日：2013-05-30
IPC分类号： C07K14/245 , C12N15/74 , C07K14/255 , C07K14/34 , C07K14/435 , C07K14/46 , C12P21/02 , C12N15/62 , C12N15/70
CPC分类号： C07K14/245 , C07K14/255 , C07K14/34 , C07K14/43504 , C07K14/43518 , C07K14/43522 , C07K14/46 , C07K2319/036 , C07K2319/21 , C07K2319/50 , C12N15/62 , C12N15/70 , C12N15/74 , C12P21/02
摘要： Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided.
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4.发明申请COMPOSITIONS AND METHODS FOR PEPTIDE EXPRESSION AND PURIFICATION USING A TYPE III SECRETION SYSTEM 有权使用III型分泌系统进行肽表达和纯化的组合物和方法公开(公告)号：US20150225466A1
公开(公告)日：2015-08-13
申请号：US14404919
申请日：2013-05-30
IPC分类号： C07K14/245 , C12P21/02 , C07K14/255 , C07K14/46 , C07K14/34 , C12N15/74 , C07K14/435
CPC分类号： C07K14/245 , C07K14/255 , C07K14/34 , C07K14/43504 , C07K14/43518 , C07K14/43522 , C07K14/46 , C07K2319/036 , C07K2319/21 , C07K2319/50 , C12N15/62 , C12N15/70 , C12N15/74 , C12P21/02
摘要： Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided.
摘要翻译： 公开了使用鞭毛III型分泌系统表达和纯化目标肽的组合物和方法。 公开了含有FlgM核酸序列，切割位点和感兴趣的核酸序列的核酸序列。 还公开了含有FlgM，切割位点和目的肽的多肽。 提供了产生具有FlgM，切割位点和目的肽的多肽的方法。
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5.发明授权公开(公告)号：US10800818B2
公开(公告)日：2020-10-13
申请号：US15459191
申请日：2017-03-15
IPC分类号： C07K14/245 , C07K14/255 , C07K14/34 , C07K14/435 , C07K14/46 , C12P21/02 , C12N15/62 , C12N15/70 , C12N15/74
摘要： Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided.
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6.发明申请公开(公告)号：US20180009851A1
公开(公告)日：2018-01-11
申请号：US15459191
申请日：2017-03-15
IPC分类号： C07K14/245 , C07K14/435 , C12N15/70 , C12P21/02 , C12N15/74 , C07K14/255 , C07K14/46 , C07K14/34 , C12N15/62
CPC分类号： C07K14/245 , C07K14/255 , C07K14/34 , C07K14/43504 , C07K14/43518 , C07K14/43522 , C07K14/46 , C07K2319/036 , C07K2319/21 , C07K2319/50 , C12N15/62 , C12N15/70 , C12N15/74 , C12P21/02
摘要： Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided.
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