公开(公告)号：US20240138770A1

公开(公告)日：2024-05-02

申请号：US18500403

申请日：2023-11-02

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Boris P. KOVATCHEV ,  Chiara FABRIS ,  Marcela MOSCOSO-VASQUEZ

IPC: A61B5/00 ,  A61B5/145

CPC classification number: A61B5/7214 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6885 ,  A61B5/746 ,  A61B2560/0475

Abstract: Embodiments can relate to systems and methods for automatically detecting sensor compression in continuous glucose monitoring in real time. A system may include at least one sensor and at least one processor in communication with the at least one sensor. The at least one processor is programmed or configured to cause the processor to retrieve first measurement data including at least one time series of blood glucose (BG) measurements, the at least one time series being measured by the at least one sensor while not subject to compression; receive, from the at least one sensor, second measurement data including at least one BG measurement; determine a clearance value between BG measurements based on the first measurement data and the second measurement data; and generate a signal output indicating that the at least one sensor is subject to compression based on the clearance value between BG measurements exceeding a predefined threshold.

公开(公告)号：US20250090754A1

公开(公告)日：2025-03-20

申请号：US18887538

申请日：2024-09-17

Applicant: University of Virginia Patent Foundation

Inventor： Marc D. BRETON ,  Jenny Lorena DIAZ CASTANEDA ,  Patricio H. COLMEGNA ,  Jose GARCIA-TIRADO ,  Maria Fernanda VILLA TAMAYO ,  Marcela MOSCOSO-VASQUEZ

IPC: A61M5/172 ,  G16H20/17

Abstract: Embodiments can relate to an insulin delivery controller which implements a processor configuration to efficiently attain an insulin delivery target. The insulin delivery controller can include a processor and a memory associated with the processor. The processor can process glucose data received from the memory, including a data representation of glycemic disturbance (d(t)). The processor can determine a glucose rate of change (G′(t)). The processor can generate a command signal to dynamically reshape a glycemic disturbance within a prediction horizon of the insulin delivery controller according to the G′(t). The processor can generate an insulin command signal for an insulin delivery unit to adjust an insulin delivery dosage amount and/or an insulin delivery dosage rate.

公开(公告)号：US20240157054A1

公开(公告)日：2024-05-16

申请号：US18507253

申请日：2023-11-13

Applicant: University of Virginia Patent Foundation

Inventor： Marcela MOSCOSO-VASQUEZ ,  Jose GARCIA-TIRADO ,  Patricio COLMEGNA ,  Marc D. BRETON

IPC: A61M5/172 ,  G16H20/17

CPC classification number: A61M5/1723 ,  G16H20/17 ,  A61M2005/1726 ,  A61M2230/201

Abstract: A method, system, and computer-readable medium are provided for an Automated Insulin Delivery (AID) system in which Model Predictive Control (MPC) thereof implements weighting of glucose target error relative to corresponding predicted blood glucose (BG) levels according to insulin on board (IOB). Accordingly, basal insulin infusion and available additional bolusing each in connection with glycemic disturbances such as unannounced meals can be proximally administered to maintain time in range (TIR) without incurring insulin stacking.