公开(公告)号：US20240189481A1

公开(公告)日：2024-06-13

申请号：US18553941

申请日：2022-04-06

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Charles E. MURRY ,  Michael REGNIER ,  Hans REINECKE ,  Xiulan YANG ,  Dasom YOO

IPC: A61L27/38 ,  A61K35/34 ,  A61L27/52 ,  A61P9/00

CPC classification number: A61L27/3826 ,  A61K35/34 ,  A61L27/52 ,  A61P9/00 ,  A61L2400/06 ,  A61L2430/20

Abstract: Described herein are compositions and methods relating to the improvement of cardiac function. Various embodiments relate to transplant compositions comprising cardiomyocytes which are engineered to be non-contractile, and to methods of using such cardiomyocytes or transplant compositions to improve cardiac function, e.g., by administering them to cardiac tissue.

公开(公告)号：US20250121038A1

公开(公告)日：2025-04-17

申请号：US18982146

申请日：2024-12-16

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Michael REGNIER ,  Charles E. MURRY ,  Xuan GUAN

IPC: A61K38/44 ,  A61K48/00 ,  C12N15/52 ,  C12N15/86

Abstract: Provided herein are isolated nucleic acids that encode a stable form of Rrm2 for the use of increasing the intracellular Rrm2 protein levels and cytosolic 2-deoxy-ATP (dATP) levels. Further provided herein are methods for treating a cardiac disease or disorder, e.g., myocardial infarction or myocardial ischemia, by administering the isolated nucleic acids, a polypeptide encoded by the isolated nucleic acids, or composition comprising the isolated nucleic acids to a subject in need thereof.

公开(公告)号：US20250145957A1

公开(公告)日：2025-05-08

申请号：US18807485

申请日：2024-08-16

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Michael REGNIER ,  Charles E. MURRY ,  Stephen D. HAUSCHKA

IPC: C12N5/077 ,  C12N9/02 ,  C12N15/85

Abstract: Provided herein are compositions and methods directed toward the discovery of improved methods for generating deoxyATP (dATP) in cells that can be delivered to a graft site in the heart to enhance cardiac function.

公开(公告)号：US20200000886A1

公开(公告)日：2020-01-02

申请号：US16457441

申请日：2019-06-28

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Michael REGNIER ,  Charles E. MURRY ,  Xuan GUAN

IPC: A61K38/44 ,  C12N15/86 ,  C12N15/52 ,  A61K48/00

Abstract: Provided herein are isolated nucleic acids that encode a stable form of Rrm2 for the use of increasing the intracellular Rrm2 protein levels and cytosolic 2-deoxy-ATP (dATP) levels. Further provided herein are methods for treating a cardiac disease or disorder, e.g., myocardial infarction or myocardial ischemia, by administering the isolated nucleic acids, a polypeptide encoded by the isolated nucleic acids, or composition comprising the isolated nucleic acids to a subject in need thereof.