公开(公告)号：US20240189481A1

公开(公告)日：2024-06-13

申请号：US18553941

申请日：2022-04-06

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Charles E. MURRY ,  Michael REGNIER ,  Hans REINECKE ,  Xiulan YANG ,  Dasom YOO

IPC: A61L27/38 ,  A61K35/34 ,  A61L27/52 ,  A61P9/00

CPC classification number: A61L27/3826 ,  A61K35/34 ,  A61L27/52 ,  A61P9/00 ,  A61L2400/06 ,  A61L2430/20

Abstract: Described herein are compositions and methods relating to the improvement of cardiac function. Various embodiments relate to transplant compositions comprising cardiomyocytes which are engineered to be non-contractile, and to methods of using such cardiomyocytes or transplant compositions to improve cardiac function, e.g., by administering them to cardiac tissue.

公开(公告)号：US20220152117A1

公开(公告)日：2022-05-19

申请号：US17440266

申请日：2020-03-17

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Charles E. MURRY ,  Xiulan YANG

IPC: A61K35/34 ,  A61K45/06 ,  A61P3/04 ,  A61P3/10 ,  C12N5/0793 ,  C12N5/077 ,  C12N9/12

Abstract: Described herein are methods and compositions related to promoting maturation of in vitro-differentiated cardiomyocytes and in vitro-differentiated neurons, and methods and compositions using the resulting cardiomyocytes and neurons.