专利检索 ap:("UNIVERSITY OF WASHINGTON") AND inv:"Walter Novak" 第 1 页

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发明授权
De novo design of protein switches 有权

公开(公告)号：US10851135B2

公开(公告)日：2020-12-01

申请号：US16796009

申请日：2020-02-20

申请人： UNIVERSITY OF WASHINGTON

发明人： Robert A. Langan , Scott Boyken , David Baker , Walter Novak , Marc Joseph Lajoie , Alfredo Quijano Rubio

IPC分类号： C07K14/00 , A61K47/69

摘要： Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.